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Chemical Compound Review

CHEMBL352469     N-methyl-N-pentyl-nitrous amide

Synonyms: CCRIS 3059, AG-D-66175, CTK8G1621, ZINC04293785, LS-102285, ...
 
 
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Disease relevance of N-methyl-N-pentyl-nitrous amide

 

High impact information on N-methyl-N-pentyl-nitrous amide

 

Chemical compound and disease context of N-methyl-N-pentyl-nitrous amide

 

Biological context of N-methyl-N-pentyl-nitrous amide

 

Anatomical context of N-methyl-N-pentyl-nitrous amide

 

Associations of N-methyl-N-pentyl-nitrous amide with other chemical compounds

 

Gene context of N-methyl-N-pentyl-nitrous amide

 

Analytical, diagnostic and therapeutic context of N-methyl-N-pentyl-nitrous amide

References

  1. Enhancement of esophageal carcinogenesis induced in rats by N-amyl-N-methylnitrosamine in the presence of 12-O-tetradecanoylphorbol-13-acetate. Matsufuji, H., Ueo, H., Mori, M., Kuwano, H., Sugimachi, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Test of catechol, tannic acid, Bidens pilosa, croton oil, and phorbol for cocarcinogenesis of esophageal tumors induced in rats by methyl-n-amylnitrosamine. Mirvish, S.S., Salmasi, S., Lawson, T.A., Pour, P., Sutherland, D. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Carcinogenesis in rat esophagus by intraperitoneal injection of different doses of methyl-n-amylnitrosamine. Bulay, O., Mirvish, S.S. Cancer Res. (1979) [Pubmed]
  4. Effect of gastroduodenal juice and dietary fat on the development of Barrett's esophagus and esophageal neoplasia: an experimental rat model. Clark, G.W., Smyrk, T.C., Mirvish, S.S., Anselmino, M., Yamashita, Y., Hinder, R.A., DeMeester, T.R., Birt, D.F. Ann. Surg. Oncol. (1994) [Pubmed]
  5. Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms. Chen, S.C., Wang, X., Xu, G., Zhou, L., Vennerstrom, J.L., Gonzalez, F., Gelboin, H.V., Mirvish, S.S. Cancer Res. (1999) [Pubmed]
  6. Metabolism of N-nitrosomethyl-n-amylamine by microsomes from human and rat esophagus. Huang, Q., Stoner, G., Resau, J., Nickols, J., Mirvish, S.S. Cancer Res. (1992) [Pubmed]
  7. Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats. Attwood, S.E., Smyrk, T.C., DeMeester, T.R., Mirvish, S.S., Stein, H.J., Hinder, R.A. Surgery (1992) [Pubmed]
  8. High incidence of esophageal cancer in esophageal achalasia by the oral administration of N-amyl-N-methylnitrosamine and its prevention by nicardipine hydrochloride in mice. Kurooka, M., Hongyo, T., Nakajima, H., Baskar, R., Li, L.Y., Fukuda, K., Sutoh, K., Miyata, M., Matsuda, H., Nomura, T. Cancer Lett. (1998) [Pubmed]
  9. Positional specificity for methyl-n-amylnitrosamine hydroxylation by cytochrome P-450 isozymes determined with monoclonal antibodies. Mirvish, S.S., Huang, Q., Ji, C., Wang, S., Park, S.S., Gelboin, H.V. Cancer Res. (1991) [Pubmed]
  10. DNA methylation in various rat tissues by the esophageal carcinogen N-nitrosomethyl-n-amylamine and six of its positional isomers. Ji, C.A., Ludeke, B.I., Kleihues, P., Wiessler, M. Chem. Res. Toxicol. (1991) [Pubmed]
  11. Use of monoclonal antibodies to cytochrome P450s to indicate the critical dealkylation and the P450s involved in methyl-n-amylnitrosamine mutagenicity in the presence of induced rat liver microsomes. Mirvish, S.S., Huang, Q., Williamson, J., Chen, S.C., Gelboin, H.V. Mutat. Res. (1995) [Pubmed]
  12. Hydroxy metabolites of methyl-n-amylnitrosamine produced by esophagus, stomach, liver, and other tissues of the neonatal to adult rat and hamster. Mirvish, S.S., Ji, C.A., Rosinsky, S. Cancer Res. (1988) [Pubmed]
  13. Formation of hydroxy derivatives, aldehydes, and nitrite from N-nitrosomethyl-n-amylamine by rat liver microsomes and by purified cytochrome P-450 IIB1. Ji, C., Mirvish, S.S., Nickols, J., Ishizaki, H., Lee, M.J., Yang, C.S. Cancer Res. (1989) [Pubmed]
  14. Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3. Morris, C.R., Chen, S.C., Zhou, L., Schopfer, L.M., Ding, X., Mirvish, S.S. Nutrition and cancer. (2004) [Pubmed]
  15. Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis. Shirai, N., Tsukamoto, T., Yamamoto, M., Iidaka, T., Sakai, H., Yanai, T., Masegi, T., Donehower, L.A., Tatematsu, M. Carcinogenesis (2002) [Pubmed]
  16. Depentylation of the rat esophageal carcinogen, methyl-n-pentylnitrosamine, by microsomes from various human and rat tissues and by cytochrome P450 2A3. Chen, S.C., Zhou, L., Ding, X., Mirvish, S.S. Drug Metab. Dispos. (2001) [Pubmed]
  17. Beta- to omega-hydroxylation of the esophageal carcinogen methyl-n-amylnitrosamine by the rat esophagus and related tissues. Mirvish, S.S., Wang, M.Y., Smith, J.W., Deshpande, A.D., Makary, M.H., Issenberg, P. Cancer Res. (1985) [Pubmed]
  18. Carcinogenicity tests of methyl-n-amylnitrosamine (MNAN) administered to newborn and adult rats and hamsters and adult mice and of 2-oxo-MNAN administered to adult rats. Mirvish, S.S., Nickols, J., Weisenburger, D.D., Smyrk, T. Cancer Lett. (1996) [Pubmed]
 
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