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Gene Review

Rgn  -  regucalcin

Mus musculus

Synonyms: AI265316, GNL, Gluconolactonase, RC, Regucalcin, ...
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Disease relevance of Rgn

  • SMP30-deficient (SMP30Y/-) mice are viable and fertile but lower in body weight and shorter in life span than the wild-type [1].

High impact information on Rgn


Chemical compound and disease context of Rgn

  • A single intraperitoneal administration of calcium chloride (5, 15, and 30 mg Ca2+/100 g body weight) to mice induced a remarkable increase in regucalcin mRNA in the liver; the increase in regucalcin mRNA levels at 30 min after calcium administration was dose-dependent [4].

Biological context of Rgn


Anatomical context of Rgn

  • To elucidate the physiological role of this protein, we introduced a null mutation of the SMP30 gene into the germ line of mice [3].
  • Immunoreactivity against anti-SMP30 antibody was mainly detected in bronchial epithelial cells and strongly detected at 6-12 months of age [6].
  • By reverse transcription-polymerase chain reaction analysis, SMP30 mRNA transcripts were found in the mouse lung, liver, kidney, testis and cerebrum [6].
  • These results suggest that SMP30 may be closely related to a signal transduction pathway in the granular duct cells of submandibular glands [7].
  • After administration of alpha-isoproterenol, a beta-adrenergic stimulant, a large numbers of small secretory granules were present in the granular duct cells and an expansion of the rough endoplasmic reticulum in SMP30-wild type (WT) mice; in contrast, little change was observed in SMP30-KO mice [7].

Associations of Rgn with chemical compounds


Regulatory relationships of Rgn


Other interactions of Rgn


Analytical, diagnostic and therapeutic context of Rgn


  1. SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span. Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S., Kubo, S., Akita, M., Maruyama, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., Ishigami, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis. Ishigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H., Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T., Maruyama, N. Am. J. Pathol. (2002) [Pubmed]
  4. Molecular cloning of the cDNA coding for regucalcin and its mRNA expression in mouse liver: the expression is stimulated by calcium administration. Murata, T., Yamaguchi, M. Mol. Cell. Biochem. (1997) [Pubmed]
  5. Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver. Kondo, Y., Ishigami, A., Kubo, S., Handa, S., Gomi, K., Hirokawa, K., Kajiyama, N., Chiba, T., Shimokado, K., Maruyama, N. FEBS Lett. (2004) [Pubmed]
  6. Senescence marker protein-30 knockout mouse as a novel murine model of senile lung. Mori, T., Ishigami, A., Seyama, K., Onai, R., Kubo, S., Shimizu, K., Maruyama, N., Fukuchi, Y. Pathol. Int. (2004) [Pubmed]
  7. Immunohistochemical localization of senescence marker protein-30 (SMP30) in the submandibular gland and ultrastructural changes of the granular duct cells in SMP30 knockout mice. Ishii, K., Tsubaki, T., Fujita, K., Ishigami, A., Maruyama, N., Akita, M. Histol. Histopathol. (2005) [Pubmed]
  8. Regulation of protein phosphatase activity by regucalcin localization in rat liver nuclei. Omura, M., Yamaguchi, M. J. Cell. Biochem. (1999) [Pubmed]
  9. Inhibitory role of regucalcin in the regulation of Ca2+ dependent protein kinases activity in rat brain neurons. Hamano, T., Yamaguchi, M. J. Neurol. Sci. (2001) [Pubmed]
  10. Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes. Ishigami, T., Fujita, T., Simbula, G., Columbano, A., Kikuchi, K., Ishigami, A., Shimosawa, T., Arakawa, Y., Maruyama, N. Pathol. Int. (2001) [Pubmed]
  11. Proteomic analysis of diet-induced hypercholesterolemic mice. Park, J.Y., Seong, J.K., Paik, Y.K. Proteomics (2004) [Pubmed]
  12. Identification of novel sequence-specific nuclear factors interacting with mouse senescence marker protein-30 gene promoter. Supakar, P.C., Fujita, T., Maruyama, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Accelerated tubular cell senescence in SMP30 knockout mice. Yumura, W., Imasawa, T., Suganuma, S., Ishigami, A., Handa, S., Kubo, S., Joh, K., Maruyama, N. Histol. Histopathol. (2006) [Pubmed]
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