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Gene Review

KLRG1  -  killer cell lectin-like receptor subfamily...

Homo sapiens

Synonyms: 2F1, C-type lectin domain family 15 member A, CLEC15A, ITIM-containing receptor MAFA-L, Killer cell lectin-like receptor subfamily G member 1, ...
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Disease relevance of KLRG1


High impact information on KLRG1

  • By using a newly generated monoclonal antibody specific for human KLRG1, we now demonstrate that expression of KLRG1 also identifies T cells in humans that are capable of secreting cytokines but that fail to proliferate after stimulation [5].
  • Besides T cells, a significant portion (approximately 50%) of human natural killer (NK) cells expressed KLRG1 [5].
  • Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) [5].
  • We further observed that CD8(+) cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57(-)KLRG1(+) cells was also identified [1].
  • Glucose influenced DNA-binding activity of MAFA in rat islets in a bell-shaped manner [4].

Biological context of KLRG1


Anatomical context of KLRG1

  • CD8(+) T cell cells specific for HIV epitopes were mostly (72-89%) KLRG1(+), even though not quite at the level of predominance noted with CMV or EBV [1].
  • Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like receptors expressed by NK cells and T lymphocytes, mainly CD8(+) effector/memory cells that can secrete cytokines but have poor proliferative capacity [1].
  • Thus, analysis of KLRG1 expression in cord blood revealed an unexpected heterogeneity of human T cells in newborns [6].
  • Similar to other inhibitory NK cell receptors, KLRG1 expression in adult peripheral blood lymphocytes is restricted to NK cells and to antigen-experienced T cells [6].
  • In vivo, pathogenic immune system activation induces dramatic changes in the expression patterns of KLRG1 among the different cell subsets [9].

Associations of KLRG1 with chemical compounds

  • The human MAFA-like receptor (MAFA-L) and the rat MAFA protein are expressed by basophils and both have an immunoreceptor tyrosine-based inhibitory motif in the cytoplasmic tail, consistent with an inhibitory role in basophil activation [10].

Regulatory relationships of KLRG1

  • Surprisingly, we identified substantial subsets of CD4 ( approximately 30%) and CD8 ( approximately 20%) alphabeta T cells in cord blood that expressed KLRG1 [6].

Other interactions of KLRG1

  • However, the recent identification of non-MHC class I ligands for inhibitory immune receptors, such as KLRG1, KLRB1 and LAIR-1, indicates that also MHC class I-independent inhibitory immune receptors play crucial roles in inducing peripheral tolerance [11].
  • Importantly, the expression profiles of the interleukin-7 receptor alpha chain (CD127) and the killer cell lectin-like receptor G1 (KLRG1) have been shown to be differentially influenced by repetitive T-cell receptor interactions [3].

Analytical, diagnostic and therapeutic context of KLRG1

  • Epitope mapping localized the 2F1 epitope to three noncontiguous regions of the IpaB protein within the alpha-helical domain that contains homology with myosin [12].


  1. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. Ibegbu, C.C., Xu, Y.X., Harris, W., Maggio, D., Miller, J.D., Kourtis, A.P. J. Immunol. (2005) [Pubmed]
  2. Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. Thimme, R., Appay, V., Koschella, M., Panther, E., Roth, E., Hislop, A.D., Rickinson, A.B., Rowland-Jones, S.L., Blum, H.E., Pircher, H. J. Virol. (2005) [Pubmed]
  3. Analysis of CD127 and KLRG1 Expression on Hepatitis C Virus-Specific CD8+ T Cells Reveals the Existence of Different Memory T-Cell Subsets in the Peripheral Blood and Liver. Bengsch, B., Spangenberg, H.C., Kersting, N., Neumann-Haefelin, C., Panther, E., von Weizs??cker, F., Blum, H.E., Pircher, H., Thimme, R. J. Virol. (2007) [Pubmed]
  4. MAFA controls genes implicated in insulin biosynthesis and secretion. Wang, H., Brun, T., Kataoka, K., Sharma, A.J., Wollheim, C.B. Diabetologia (2007) [Pubmed]
  5. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Voehringer, D., Koschella, M., Pircher, H. Blood (2002) [Pubmed]
  6. Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history. Marcolino, I., Przybylski, G.K., Koschella, M., Schmidt, C.A., Voehringer, D., Schlesier, M., Pircher, H. Eur. J. Immunol. (2004) [Pubmed]
  7. Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Voehringer, D., Kaufmann, M., Pircher, H. Immunogenetics (2001) [Pubmed]
  8. Human MAFA has alternatively spliced variants. Lamers, M.B., Lamont, A.G., Williams, D.H. Biochim. Biophys. Acta (1998) [Pubmed]
  9. KLRG1 binds cadherins and preferentially associates with SHIP-1. Tessmer, M.S., Fugere, C., Stevenaert, F., Naidenko, O.V., Chong, H.J., Leclercq, G., Brossay, L. Int. Immunol. (2007) [Pubmed]
  10. MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. Butcher, S., Arney, K.L., Cook, G.P. Eur. J. Immunol. (1998) [Pubmed]
  11. Non-MHC ligands for inhibitory immune receptors: Novel insights and implications for immune regulation. Lebbink, R.J., Meyaard, L. Mol. Immunol. (2007) [Pubmed]
  12. Myosin-cross-reactive epitope of Shigella flexneri invasion plasmid antigen B. Oaks, E.V., Turbyfill, K.R. Infect. Immun. (1992) [Pubmed]
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