Gene Review:
ETV1 - ets variant 1
Homo sapiens
Synonyms:
ER81, ETS translocation variant 1, Ets-related protein 81
- TMPRSS2:ERG Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor-Negative Prostate Cancer. Hermans, K.G., van Marion, R., van Dekken, H., Jenster, G., van Weerden, W.M., Trapman, J. Cancer Res. (2006)
- A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Jeon, I.S., Davis, J.N., Braun, B.S., Sublett, J.E., Roussel, M.F., Denny, C.T., Shapiro, D.N. Oncogene (1995)
- HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. Dowdy, S.C., Mariani, A., Janknecht, R. J. Biol. Chem. (2003)
- Gene expression profiling of the bone marrow mononuclear cells from patients with myelodysplastic syndrome. Qian, J., Chen, Z., Wang, W., Cen, J., Xue, Y. Oncol. Rep. (2005)
- TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Cerveira, N., Ribeiro, F.R., Peixoto, A., Costa, V., Henrique, R., Jer??nimo, C., Teixeira, M.R. Neoplasia (2006)
- ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Cai, C., Hsieh, C.L., Omwancha, J., Zheng, Z., Chen, S.Y., Baert, J.L., Shemshedini, L. Mol. Endocrinol. (2007)
- Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Brown, T.A., McKnight, S.L. Genes Dev. (1992)
- The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Guo, B., Sallis, R.E., Greenall, A., Petit, M.M., Jansen, E., Young, L., Van de Ven, W.J., Sharrocks, A.D. Mol. Cell. Biol. (2006)
- Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Goueli, B.S., Janknecht, R. Mol. Cell. Biol. (2004)
- Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Goel, A., Janknecht, R. Mol. Cell. Biol. (2003)
- Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. Goel, A., Janknecht, R. J. Biol. Chem. (2004)
- Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human. Coutte, L., Monté, D., Imai, K., Pouilly, L., Dewitte, F., Vidaud, M., Adamski, J., Baert, J.L., de Launoit, Y. Oncogene (1999)
- Molecular characterization of the ets-related human transcription factor ER81. Monté, D., Coutte, L., Baert, J.L., Angeli, I., Stéhelin, D., de Launoit, Y. Oncogene (1995)
- Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer. Rubin, M.A., Chinnaiyan, A.M. Lab. Invest. (2006)
- Phylogenetically interrelated ETS genes, ETV1, ERM and E1A-F locate on different chromosomes. Jeon, I.S., Shapiro, D.N. J. Korean Med. Sci. (1998)
- Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Papoutsopoulou, S., Janknecht, R. Mol. Cell. Biol. (2000)
- Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis. Yang, L., Fox, S.A., Kirby, J.L., Troan, B.V., Hinton, B.T. Biol. Reprod. (2006)
- Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. Janknecht, R. J. Biol. Chem. (2001)
- Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. Bosc, D.G., Janknecht, R. J. Cell. Biochem. (2002)
- Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Janknecht, R. Oncogene (2003)
- Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Yoshimoto, M., Joshua, A.M., Chilton-Macneill, S., Bayani, J., Selvarajah, S., Evans, A.J., Zielenska, M., Squire, J.A. Neoplasia (2006)
- EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene. Im, Y.H., Kim, H.T., Lee, C., Poulin, D., Welford, S., Sorensen, P.H., Denny, C.T., Kim, S.J. Cancer Res. (2000)
- Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Tomlins, S.A., Rhodes, D.R., Perner, S., Dhanasekaran, S.M., Mehra, R., Sun, X.W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., Lee, C., Montie, J.E., Shah, R.B., Pienta, K.J., Rubin, M.A., Chinnaiyan, A.M. Science (2005)
- Localization of a novel locus for alopecia with mental retardation syndrome to chromosome 3q26.33-q27.3. John, P., Ali, G., Chishti, M.S., Naqvi, S.M., Leal, S.M., Ahmad, W. Hum. Genet. (2006)