Gene Review:
Il27 - interleukin 27
Mus musculus
Synonyms:
IL-27, IL-27 subunit alpha, IL-27-A, IL-27p28, IL27-A, ...
- IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis. Li, J., Gran, B., Zhang, G.X., Rostami, A., Kamoun, M. J. Neurol. Sci. (2005)
- Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Wozniak, T.M., Ryan, A.A., Triccas, J.A., Britton, W.J. Infect. Immun. (2006)
- Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Batten, M., Li, J., Yi, S., Kljavin, N.M., Danilenko, D.M., Lucas, S., Lee, J., de Sauvage, F.J., Ghilardi, N. Nat. Immunol. (2006)
- Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. Wirtz, S., Tubbe, I., Galle, P.R., Schild, H.J., Birkenbach, M., Blumberg, R.S., Neurath, M.F. J. Exp. Med. (2006)
- C5a negatively regulates toll-like receptor 4-induced immune responses. Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C., Köhl, J. Immunity (2005)
- The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Villarino, A., Hibbert, L., Lieberman, L., Wilson, E., Mak, T., Yoshida, H., Kastelein, R.A., Saris, C., Hunter, C.A. Immunity (2003)
- Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Stumhofer, J.S., Laurence, A., Wilson, E.H., Huang, E., Tato, C.M., Johnson, L.M., Villarino, A.V., Huang, Q., Yoshimura, A., Sehy, D., Saris, C.J., O'shea, J.J., Hennighausen, L., Ernst, M., Hunter, C.A. Nat. Immunol. (2006)
- Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-{gamma}-mediated pathways. Liu, J., Guan, X., Ma, X. J. Exp. Med. (2007)
- Induction of IgG2a class switching in B cells by IL-27. Yoshimoto, T., Okada, K., Morishima, N., Kamiya, S., Owaki, T., Asakawa, M., Iwakura, Y., Fukai, F., Mizuguchi, J. J. Immunol. (2004)
- IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice. Pearl, J.E., Khader, S.A., Solache, A., Gilmartin, L., Ghilardi, N., deSauvage, F., Cooper, A.M. J. Immunol. (2004)
- Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Zhang, J.H., He, H., Borzychowski, A.M., Takeda, K., Akira, S., Croy, B.A. Biol. Reprod. (2003)
- Expression of IL-27 in human Th1-associated granulomatous diseases. Larousserie, F., Pflanz, S., Coulomb-L'Herminé, A., Brousse, N., Kastelein, R., Devergne, O. J. Pathol. (2004)
- Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. Villarino, A.V., Larkin, J., Saris, C.J., Caton, A.J., Lucas, S., Wong, T., de Sauvage, F.J., Hunter, C.A. J. Immunol. (2005)
- WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Takeda, A., Hamano, S., Shiraishi, H., Yoshimura, T., Ogata, H., Ishii, K., Ishibashi, T., Yoshimura, A., Yoshida, H. Int. Immunol. (2005)
- IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. Molle, C., Nguyen, M., Flamand, V., Renneson, J., Trottein, F., De Wit, D., Willems, F., Goldman, M., Goriely, S. J. Immunol. (2007)
- Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Oniki, S., Nagai, H., Horikawa, T., Furukawa, J., Belladonna, M.L., Yoshimoto, T., Hara, I., Nishigori, C. Cancer Res. (2006)
- The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. Artis, D., Villarino, A., Silverman, M., He, W., Thornton, E.M., Mu, S., Summer, S., Covey, T.M., Huang, E., Yoshida, H., Koretzky, G., Goldschmidt, M., Wu, G.D., de Sauvage, F., Miller, H.R., Saris, C.J., Scott, P., Hunter, C.A. J. Immunol. (2004)
- IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J., Yoshimoto, T. J. Immunol. (2006)
- Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27. Goldberg, R., Zohar, Y., Wildbaum, G., Geron, Y., Maor, G., Karin, N. J. Immunol. (2004)
- Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Sonobe, Y., Yawata, I., Kawanokuchi, J., Takeuchi, H., Mizuno, T., Suzumura, A. Brain Res. (2005)
- Rapid phosphorylation of 28-kDa heat-shock protein by treatment with okadaic acid and phorbol ester of BALB/MK-2 mouse keratinocytes. Kasahara, K., Ikuta, T., Chida, K., Asakura, R., Kuroki, T. Eur. J. Biochem. (1993)
- Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. Brockway, S.M., Lu, X.T., Peters, T.R., Dermody, T.S., Denison, M.R. J. Virol. (2004)