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Men1  -  multiple endocrine neoplasia I

Rattus norvegicus

Synonyms: Menin
 
 
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Disease relevance of Men1

 

High impact information on Men1

 

Biological context of Men1

 

Anatomical context of Men1

  • Indeed, specific reduction of menin expression by transfected antisense cDNA in the rat duodenal crypt-like cell line, IEC-17, increased cell proliferation [10].
  • These results indicate that menin contributes to proliferation control in intestinal epithelial cells [10].
  • Its known abundant expression in several types of cells with high proliferative capacity led us to investigate the physiological function of the protein menin in intestinal epithelium, one of the most rapidly growing epithelia [10].
  • Immunoblotting and immunocytochemical analysis of the COS-7 cells transfected with a rat menin-expression vector revealed that the translated product has a molecular mass of approximately 70 kDa, and is localized mainly in the nucleus [11].
  • JunD appears to be one mediator of this effect, since JunD was a major component of the AP1-DNA binding complex in granulosa cells, and menin, a selective inhibitor of JunD, blocked transcription of -73COL-luciferase [12].
 

Associations of Men1 with chemical compounds

  • In cells with a high level of menin expression, both insulin secretion and thymidine incorporation into DNA were inhibited when compared to mock-transfected cells [5].
 

Other interactions of Men1

 

Analytical, diagnostic and therapeutic context of Men1

References

  1. Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Karges, W., Maier, S., Wissmann, A., Dralle, H., Dosch, H.M., Boehm, B.O. Biochim. Biophys. Acta (1999) [Pubmed]
  2. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival. De Vita, G., Melillo, R.M., Carlomagno, F., Visconti, R., Castellone, M.D., Bellacosa, A., Billaud, M., Fusco, A., Tsichlis, P.N., Santoro, M. Cancer Res. (2000) [Pubmed]
  3. The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. Melillo, R.M., Cirafici, A.M., De Falco, V., Bellantoni, M., Chiappetta, G., Fusco, A., Carlomagno, F., Picascia, A., Tramontano, D., Tallini, G., Santoro, M. Am. J. Pathol. (2004) [Pubmed]
  4. Circulating fibroblast growth factor-like autoantibodies in two patients with multiple endocrine neoplasia type 1 and prolactinoma. Zimering, M.B., Riley, D.J., Thakker-Varia, S., Walker, A.M., Lakshminaryan, V., Shah, R., Brandi, M.L., Ezzat, S., Katsumata, N., Friesen, H.G. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  5. The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Sayo, Y., Murao, K., Imachi, H., Cao, W.M., Sato, M., Dobashi, H., Wong, N.C., Ishida, T. Endocrinology (2002) [Pubmed]
  6. A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells. Califano, D., D'Alessio, A., Colucci-D'Amato, G.L., De Vita, G., Monaco, C., Santelli, G., Di Fiore, P.P., Vecchio, G., Fusco, A., Santoro, M., de Franciscis, V. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Fritz, A., Walch, A., Piotrowska, K., Rosemann, M., Schäffer, E., Weber, K., Timper, A., Wildner, G., Graw, J., Höfler, H., Atkinson, M.J. Cancer Res. (2002) [Pubmed]
  8. Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B. Salvatore, D., Melillo, R.M., Monaco, C., Visconti, R., Fenzi, G., Vecchio, G., Fusco, A., Santoro, M. Cancer Res. (2001) [Pubmed]
  9. Cell cycle regulation of menin expression. Kaji, H., Canaff, L., Goltzman, D., Hendy, G.N. Cancer Res. (1999) [Pubmed]
  10. Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells. Ratineau, C., Bernard, C., Poncet, G., Blanc, M., Josso, C., Fontanière, S., Calender, A., Chayvialle, J.A., Zhang, C.X., Roche, C. J. Biol. Chem. (2004) [Pubmed]
  11. Structure and distribution of rat menin mRNA. Maruyama, K., Tsukada, T., Hosono, T., Ohkura, N., Kishi, M., Honda, M., Nara-Ashizawa, N., Nagasaki, K., Yamaguchi, K. Mol. Cell. Endocrinol. (1999) [Pubmed]
  12. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma, S.C., Richards, J.S. J. Biol. Chem. (2000) [Pubmed]
  13. Zollinger-Ellison syndrome. Recognition and management of acid hypersecretion. Maton, P.N. Drugs (1996) [Pubmed]
  14. Up-regulation of ret by reserpine in the adult rat adrenal medulla. Powers, J.F., Brachold, J.M., Ehsani, S.A., Tischler, A.S. Neuroscience (2005) [Pubmed]
  15. Adrenal cortex transplantation after bilateral total adrenalectomy in the rat. Scheumann, G.F., Hiller, W.F., Schroder, S., Schurmeyer, T., Klempnauer, J., Dralle, H. Henry Ford Hosp. Med. J. (1989) [Pubmed]
 
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