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Gene Review

MYL3  -  myosin, light chain 3, alkali; ventricular...

Homo sapiens

Synonyms: CMH8, CMLC1, Cardiac myosin light chain 1, MLC1SB, MLC1V, ...
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Disease relevance of MYL3


High impact information on MYL3


Chemical compound and disease context of MYL3


Biological context of MYL3


Anatomical context of MYL3

  • Levels of bacterial spores per square meter on the VLC-1 and VLC-2 were 1.6 x 10(2) and 9.7 x 10(1), respectively, prior to dry-heat sterilization [12].

Associations of MYL3 with chemical compounds


Physical interactions of MYL3

  • Synthetic N-terminal peptides revealed specific actin binding, with a significantly (P<0.01) lower dissociation constant (K(D)) for the hVLC-1/1-15-actin complex compared with the K(D) value of the hALC-1/1-15-actin complex [17].

Other interactions of MYL3

  • In contrast to cTnI and cTnT, cMLC-1 and bMHC time courses were not significantly influenced by early reperfusion [18].
  • Furthermore, preincubation of G-actin with P5-14 of both ALC-1 and VLC-1 decreased the amount of G-actin recovered from the affinity beads in a concentration-dependent manner [19].
  • These results suggested that CArG box (-96 to -87) has an important role in the positive regulation of the VLC1 gene and this element may be involved in the co-regulation of VLC1 and cardiac alpha-actin genes [20].

Analytical, diagnostic and therapeutic context of MYL3


  1. Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan. Hansen, M.S., Stanton, E.B., Gawad, Y., Packer, M., Pitt, B., Swedberg, K., Rouleau, J.L. Am. J. Cardiol. (2002) [Pubmed]
  2. Different time courses of cardiac contractile proteins after acute myocardial infarction. Mair, J., Wagner, I., Jakob, G., Lechleitner, P., Dienstl, F., Puschendorf, B., Michel, G. Clin. Chim. Acta (1994) [Pubmed]
  3. Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes. Mukuta, T., Yoshikawa, N., Arreaza, G., Resetkova, E., Leushner, J., Song, Y.H., Akasu, F., Onaya, T., Volpé, R. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  4. Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Müller, O.J., Leuchs, B., Pleger, S.T., Grimm, D., Franz, W.M., Katus, H.A., Kleinschmidt, J.A. Cardiovasc. Res. (2006) [Pubmed]
  5. Synthetic peptide immunogens for the development of a cardiac myosin light chain-1 specific radioimmunoassay. Nicol, P.D., Matsueda, G.R., Haber, E., Khaw, B.A. J. Nucl. Med. (1993) [Pubmed]
  6. Increased expression and regional differences of atrial myosin light chain 1 in human ventricles with old myocardial infarction. Analyses using two monoclonal antibodies. Nakao, K., Yasue, H., Fujimoto, K., Jougasaki, M., Yamamoto, H., Hitoshi, Y., Takatsu, K., Miyamoto, E. Circulation (1992) [Pubmed]
  7. Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary reperfusion in patients with acute myocardial infarction. Isobe, M., Nagai, R., Ueda, S., Tsuchimochi, H., Nakaoka, H., Takaku, F., Yamaguchi, T., Machii, K., Nobuyoshi, M., Yazaki, Y. Circulation (1987) [Pubmed]
  8. Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. Kurabayashi, M., Komuro, I., Tsuchimochi, H., Takaku, F., Yazaki, Y. J. Biol. Chem. (1988) [Pubmed]
  9. Atrial and brain natriuretic peptides in cardiovascular diseases. Naruse, M., Takeyama, Y., Tanabe, A., Hiroshige, J., Naruse, K., Yoshimoto, T., Tanaka, M., Katagiri, T., Demura, H. Hypertension (1994) [Pubmed]
  10. Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy. Kabaeva, Z.T., Perrot, A., Wolter, B., Dietz, R., Cardim, N., Correia, J.M., Schulte, H.D., Aldashev, A.A., Mirrakhimov, M.M., Osterziel, K.J. Eur. J. Hum. Genet. (2002) [Pubmed]
  11. Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4). Cohen-Haguenauer, O., Barton, P.J., Van Cong, N., Cohen, A., Masset, M., Buckingham, M., Frézal, J. Hum. Genet. (1989) [Pubmed]
  12. Microbiological profiles of the Viking spacecraft. Puleo, J.R., Fields, N.D., Bergstrom, S.L., Oxborrow, G.S., Stabekis, P.D., Koukol, R. Appl. Environ. Microbiol. (1977) [Pubmed]
  13. Isolation of cardiac myosin light-chain isotypes by chromatofocusing. Comparison of human cardiac atrial light-chain 1 and foetal ventricular light-chain 1. Vincent, N.D., Cummins, P. Eur. J. Biochem. (1985) [Pubmed]
  14. Myosin adenosinetriphosphatase activity and light chain subunit composition of human right and left ventricle. Price, K.M., Littler, W.A., Cummins, P. Cardiovasc. Res. (1980) [Pubmed]
  15. Assessment of myocardial damage by circulating cardiac myosin light chain I after heart transplantation. Uchino, T., Belboul, A., el-Gatit, A., Roberts, D., Berglin, E., William-Olsson, G. J. Heart Lung Transplant. (1994) [Pubmed]
  16. Atrial and ventricular myosins from human hearts. II. Isoenzyme distribution after myocardial infarction. Hoffmann, U., Axmann, C., Palm, N. Basic Res. Cardiol. (1987) [Pubmed]
  17. Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats. Haase, H., Dobbernack, G., Tünnemann, G., Karczewski, P., Cardoso, C., Petzhold, D., Schlegel, W.P., Lutter, S., Pierschalek, P., Behlke, J., Morano, I. FASEB J. (2006) [Pubmed]
  18. Concentration time courses of troponin and myosin subunits after acute myocardial infarction. Mair, J., Thome-Kromer, B., Wagner, I., Lechleitner, P., Dienstl, F., Puschendorf, B., Michel, G. Coron. Artery Dis. (1994) [Pubmed]
  19. Different actin affinities of human cardiac essential myosin light chain isoforms. Morano, I., Haase, H. FEBS Lett. (1997) [Pubmed]
  20. The myosin gene switching in human cardiac hypertrophy. Kurabayashi, M., Shibasaki, Y., Komuro, I., Tsuchimochi, H., Yazaki, Y. Jpn. Circ. J. (1990) [Pubmed]
  21. Myosin light chain gene expression associated with disease states of the human heart. Trahair, T., Yeoh, T., Cartmill, T., Keogh, A., Spratt, P., Chang, V., dos Remedios, C.G., Gunning, P. J. Mol. Cell. Cardiol. (1993) [Pubmed]
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