The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PCP4  -  Purkinje cell protein 4

Homo sapiens

Synonyms: Brain-specific antigen PCP-4, Brain-specific polypeptide PEP-19, PEP-19, PEP19
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PCP4


Psychiatry related information on PCP4


High impact information on PCP4


Biological context of PCP4


Anatomical context of PCP4

Associations of PCP4 with chemical compounds

  • Truncated camstatin is selectively phosphorylated by four isoforms of protein kinase C. Furthermore, treatment of full-length PEP-19 with PKCgamma catalyzes phosphorylation of the same serine residue [11].
  • Through measurements on the respective methylethers (anisoles) the O-H bond of 2,4,6-TCP turns out to be 5 kcal/ mol, and that in PCP 4 kcal/mol, less strong than O-H in phenol itself [12].

Other interactions of PCP4

  • Among the genes identified, decreased expressions of NEFH and PCP4/PEP19 were further examined [13].
  • While most of the abnormal neurons in the lesion appear to be derived from granule cells, several Purkinje cell specific polyclonal and monoclonal antibodies, including L7, PEP 19 and calbindin, labeled a minor subpopulation [14].
  • We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling [8].
  • We found that antibodies raised against the first 13 N-terminal amino acids of LPI, not present in PEP19, recognize a protein enriched in the developing rat brain [8].

Analytical, diagnostic and therapeutic context of PCP4

  • Murine PCP4 expression in the brain has been detected by Northern blot analysis to be mainly post-natal and in the adult to have a neuronal pattern [9].
  • The H(alpha) chemical shifts and the circular dichroism spectra of the camstatins are consistent with those of "nascent helices". We submit that PEP-19 is a PKC substrate, and that the phosphorylation state of PEP-19 may play a role in the modulation of calmodulin-dependent signaling [11].


  1. Molecular genetic characterization and comparative mapping of the human PCP4 gene. Cabin, D.E., Gardiner, K., Reeves, R.H. Somat. Cell Mol. Genet. (1996) [Pubmed]
  2. PEP-19 overexpression in human uterine leiomyoma. Kanamori, T., Takakura, K., Mandai, M., Kariya, M., Fukuhara, K., Kusakari, T., Momma, C., Shime, H., Yagi, H., Konishi, M., Suzuki, A., Matsumura, N., Nanbu, K., Fujita, J., Fujii, S. Mol. Hum. Reprod. (2003) [Pubmed]
  3. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. Felizola, S.J., Nakamura, Y., Ono, Y., Kitamura, K., Kikuchi, K., Onodera, Y., Ise, K., Takase, K., Sugawara, A., Hattangady, N., Rainey, W.E., Satoh, F., Sasano, H. J. Mol. Endocrinol. (2014) [Pubmed]
  4. PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. Utal, A.K., Stopka, A.L., Roy, M., Coleman, P.D. Neuroscience (1998) [Pubmed]
  5. Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum. Slemmon, J.R., Hughes, C.M., Campbell, G.A., Flood, D.G. J. Neurosci. (1994) [Pubmed]
  6. An immunochemical analysis of the distribution of a brain-specific polypeptide, PEP-19. Ziai, M.R., Sangameswaran, L., Hempstead, J.L., Danho, W., Morgan, J.I. J. Neurochem. (1988) [Pubmed]
  7. PCP4 maps between D21S345 and P31P10SP6 on chromosome 21q22.2-->q22.3. Hubert, R.S., Korenberg, J.R. Cytogenet. Cell Genet. (1997) [Pubmed]
  8. Cloning of a rat-specific long PCP4/PEP19 isoform. Sala, A., Scaturro, M., Proia, P., Schiera, G., Balistreri, E., Aflalo-Rattenbach, R., Créau, N., Di Liegro, I. Int. J. Mol. Med. (2007) [Pubmed]
  9. PCP4 is highly expressed in ectoderm and particularly in neuroectoderm derivatives during mouse embryogenesis. Thomas, S., Thiery, E., Aflalo, R., Vayssettes, C., Verney, C., Berthuy, I., Créau, N. Gene Expr. Patterns (2003) [Pubmed]
  10. Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3. Chen, H., Bouras, C., Antonarakis, S.E. Hum. Genet. (1996) [Pubmed]
  11. The influence of phosphorylation on the activity and structure of the neuronal IQ motif protein, PEP-19. Dickerson, J.B., Morgan, M.A., Mishra, A., Slaughter, C.A., Morgan, J.I., Zheng, J. Brain Res. (2006) [Pubmed]
  12. Radical/radical vs radical/molecule reactions in the formation of PCDD/Fs from (chloro)phenols in incinerators. Louw, R., Ahonkhai, S.I. Chemosphere (2002) [Pubmed]
  13. Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Iwamoto, K., Bundo, M., Yamamoto, M., Ozawa, H., Saito, T., Kato, T. Neurosci. Res. (2004) [Pubmed]
  14. Immunohistochemistry and proliferative activity in Lhermitte-Duclos disease. Hair, L.S., Symmans, F., Powers, J.M., Carmel, P. Acta Neuropathol. (1992) [Pubmed]
WikiGenes - Universities