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STAP2  -  signal transducing adaptor family member 2

Homo sapiens

Synonyms: BKS, BRK substrate, Breast tumor kinase substrate, STAP-2, Signal-transducing adaptor protein 2
 
 
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Disease relevance of STAP2

  • STAP-2 was identical to a recently cloned adaptor molecule, BKS, a substrate of BRK (breast tumor kinase) tyrosine kinase, although its function is still unknown [1].
  • Although they share approximately 88% of their genome with NOD mice including the H2g7 haplotype, NOR mice remain free of T cell-mediated autoimmune diabetes (IDDM), due to non-MHC genes of C57BLKS/J (BKS) origin [2].
  • CONCLUSION: The nonfreeze myopic keratomileusis procedure, with BKS 1000, substantially reduces moderate to high myopia, but predictability of refractive outcome is only fair, and the frequency of optical complications including irregular astigmatism is higher than desired [3].
 

High impact information on STAP2

  • The physiological role of these interactions is not fully understood, but in studies of overexpression of STAP-2/BKS, cytokine-induced tyrosine phosphorylation and transcriptional activation of STAT5 was diminished [4].
  • In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth [4].
  • A recombinant PTK6 Kinase domain connected to the Linker region had catalytic activity in terms of autophosphorylation, phosphorylation of a PTK6 substrate, BKS, and phosphorylation of an oligopeptide substrate, whereas the Kinase domain itself, or one connected to a Linker region containing a W184A substitution, did not [5].
  • Overexpression of wild-type STAP-2, but not of mutants lacking this motif, enhanced the AP response element reporter activity and an AP protein production [6].
  • Our previous studies revealed that STAP-2 binds to signal transducer and activator of transcription 3 (STAT3) and STAT5, and regulates their signaling pathways [7].
 

Biological context of STAP2

 

Anatomical context of STAP2

  • Moreover, endogenous STAP-2 was phosphorylated at Tyr250 following LIF stimulation of murine M1 cell line [7].
 

Associations of STAP2 with chemical compounds

  • Under the auspices of the Coordinating Board of Indonesian Fertility Research (BKS PENFIN), a clinical trial was undertaken to examine the safety and effectiveness of the quinacrine pellet method for nonsurgical female sterilization [9].
  • A plano corneal disc was cut with a BKS 1000 microkeratome, followed by argon fluoride excimer laser ablation of the stroma with the Summit Eximed UV 200LA laser (Summit Technology, Inc, Waltham, Mass), either of the resected disc (28 eyes) or in situ on the stromal bed (two eyes) [10].
 

Enzymatic interactions of STAP2

  • In addition, BKS recruited an unidentified 100 kDa protein that was also phosphorylated on tyrosine residues in the presence of BRK [11].
 

Regulatory relationships of STAP2

 

Other interactions of STAP2

References

  1. Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Yamamoto, T., Yumioka, T., Sekine, Y., Sato, N., Minoguchi, M., Yoshimura, A., Matsuda, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. Serreze, D.V., Bridgett, M., Chapman, H.D., Chen, E., Richard, S.D., Leiter, E.H. J. Immunol. (1998) [Pubmed]
  3. Nonfreeze myopic keratomileusis for myopia in 158 eyes. Laroche, L., Gauthier, L., Thenot, J.C., Lagoutte, F., Nordmann, J.P., Denis, P., Borderie, V., Giral, P., Saraux, H. Journal of refractive and corneal surgery. (1994) [Pubmed]
  4. Physical and functional interactions between STAP-2/BKS and STAT5. Sekine, Y., Yamamoto, T., Yumioka, T., Sugiyama, K., Tsuji, S., Oritani, K., Shimoda, K., Minoguchi, M., Yoshimura, A., Matsuda, T. J. Biol. Chem. (2005) [Pubmed]
  5. An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. Kim, H.I.e., Lee, S.T. J. Biol. Chem. (2005) [Pubmed]
  6. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. Minoguchi, M., Minoguchi, S., Aki, D., Joo, A., Yamamoto, T., Yumioka, T., Matsuda, T., Yoshimura, A. J. Biol. Chem. (2003) [Pubmed]
  7. Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity. Sekine, Y., Tsuji, S., Ikeda, O., Kakisaka, M., Sugiyama, K., Yoshimura, A., Matsuda, T. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  8. Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Purcell, M.K., Mu, J.L., Higgins, D.C., Elango, R., Whitmore, H., Harris, S., Paigen, B. Mamm. Genome (2001) [Pubmed]
  9. Clinical evaluation of quinacrine pellets for chemical female sterilization. Agoestina, T., Kusuma, I. Advances in contraception : the official journal of the Society for the Advancement of Contraception. (1992) [Pubmed]
  10. Myopic keratomileusis with the excimer laser: one-year follow up. Buratto, L., Ferrari, M., Genisi, C. Refractive & corneal surgery. (1993) [Pubmed]
  11. A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. Mitchell, P.J., Sara, E.A., Crompton, M.R. Oncogene (2000) [Pubmed]
 
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