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FSD1  -  fibronectin type III and SPRY domain...

Homo sapiens

Synonyms: Fibronectin type III and SPRY domain-containing protein 1, GLFND, MGC3213, MID1-related protein 1, MIR1, ...
 
 
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Disease relevance of FSD1

 

High impact information on FSD1

 

Biological context of FSD1

 

Anatomical context of FSD1

  • This study suggests that the major FSD component (FSD1) represents a new and unique dehalogenating or dehydrogenating enzyme present in rat liver cytosol [8].
 

Associations of FSD1 with chemical compounds

  • The first form, FSD1 (molecular weight 38 kDa), contained 81% of the total cytosolic fluoroacetate defluorination activity and did not bind to the glutathione-affinity, orange A or mono P columns used in the purification procedures [8].
  • The ethylene synthesis and perception inhibitors also reduced the accumulation of Mirl-CP and its transcript mir1 in response to herbivory [9].
  • The maize gene mir1 encoded a cystein proteinase which is resistant to fall armyworm [7].
  • Here, we found that MIR1, but not MIR2, promoted down-regulation of MHC I molecules lacking lysine residues in their intracytoplasmic domain [1].
 

Other interactions of FSD1

  • FSD1 has a BBC, FN3 and SPRY domain, it is distantly related to the midline 1 gene and is expressed only in the brain [5].
  • The computational redesign of the second zinc finger of Zif268 to produce a 28 residue peptide (FSD-1) that assumes a betabetaalpha fold without metal binding was recently reported [10].
 

Analytical, diagnostic and therapeutic context of FSD1

References

  1. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Cadwell, K., Coscoy, L. Science (2005) [Pubmed]
  2. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., Georges, M. Nat. Genet. (2006) [Pubmed]
  3. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. Coscoy, L., Sanchez, D.J., Ganem, D. J. Cell Biol. (2001) [Pubmed]
  4. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. Manabe, R., Whitmore, L., Weiss, J.M., Horwitz, A.R. Curr. Biol. (2002) [Pubmed]
  5. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. Biochim. Biophys. Acta (2001) [Pubmed]
  6. A novel centrosome-associated protein with affinity for microtubules. Stein, P.A., Toret, C.P., Salic, A.N., Rolls, M.M., Rapoport, T.A. J. Cell. Sci. (2002) [Pubmed]
  7. Comparative physical localization of maize mir1 gene in Zea mays L. and Coix lacryma-jobi L. Han, Y.H., Wang, X.L., Liu, L.H., Song, Y.C. Yi Chuan Xue Bao (2004) [Pubmed]
  8. Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol. Tu, L.Q., Chen, Y.Y., Wright, P.F., Rix, C.J., Bolton-Grob, R., Ahokas, J.T. Xenobiotica (2005) [Pubmed]
  9. Ethylene signaling mediates a maize defense response to insect herbivory. Harfouche, A.L., Shivaji, R., Stocker, R., Williams, P.W., Luthe, D.S. Mol. Plant Microbe Interact. (2006) [Pubmed]
  10. The beta-beta-alpha fold: explorations in sequence space. Sarisky, C.A., Mayo, S.L. J. Mol. Biol. (2001) [Pubmed]
 
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