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TCL1A  -  T-cell leukemia/lymphoma 1A

Homo sapiens

Synonyms: Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, T-cell leukemia/lymphoma protein 1A, TCL1
 
 
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Disease relevance of TCL1A

 

High impact information on TCL1A

 

Biological context of TCL1A

  • The murine TCL1 gene resides on mouse chromosome 12 and is homologous to the human TCL1 and MTCP1 genes [7].
  • Our data show that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation [6].
  • Comigration of high-molecular weight DNA fragments involved with t(7;14) and t(14;14) translocations suggests the presence of a cluster of breakpoints in the 14q32.1 region, the site of a putative oncogene, TCL1 [8].
  • Comparison of the gene expression patterns of an EBV-negative clone of the originally EBV-positive BL line Akata, with its Neo(R)-EBV derivative, revealed a significant difference in the expression of the T cell leukemia 1 oncogene (TCL-1) [9].
  • The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas [10].
 

Anatomical context of TCL1A

 

Associations of TCL1A with chemical compounds

  • TMA analysis was applied on a distinct series of 36 formalin-fixed, paraffin-embedded DLCL samples and showed that TCL1A immunoexpression was correlated with either higher relapse (p=0.02) or lower 5-year overall survival (p=0.009) rates [12].
  • Identification of Nerve Growth Factor-responsive Element of the TCL1 Promoter as a Novel Negative Regulatory Element [14].
  • Induction of AKT serine/threonine kinase activity is augmented by the T-cell leukemia-1 (TCL1) oncoprotein through a physical association requiring the AKT pleckstrin homology domain [15].
  • We then demonstrated the in vivo clinical activity of low-dose fludarabine in transgenic TCL-1 mice with active leukemia [16].
  • Genomic bisulfite sequencing corroborated this prediction and revealed three distinct patterns of methylation for the silenced B29 and TCL1 promoters [17].
  • In primary tumors and TCL1-transfected T-cell lines, TCR engagement leads to rapid recruitment of TCL1 and AKT to transient membrane activation complexes that include TCR-associated tyrosine kinases, including LCK [18].
 

Physical interactions of TCL1A

 

Regulatory relationships of TCL1A

 

Other interactions of TCL1A

 

Analytical, diagnostic and therapeutic context of TCL1A

References

  1. The role of TCL1 in human T-cell leukemia. Pekarsky, Y., Hallas, C., Croce, C.M. Oncogene (2001) [Pubmed]
  2. Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. Fears, S., Chakrabarti, S.R., Nucifora, G., Rowley, J.D. Cancer Genet. Cytogenet. (2002) [Pubmed]
  3. Chromosomal and genetic aberrations differ with meningioma subtype. Wada, K., Maruno, M., Suzuki, T., Kagawa, N., Hashiba, T., Fujimoto, Y., Hashimoto, N., Izumoto, S., Yoshimine, T. Brain tumor pathology. (2004) [Pubmed]
  4. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Fu, Z.Q., Du Bois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Rothstein, J.L., Croce, C.M., Weber, I.T., Harrison, R.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Molecular basis of mature T-cell leukemia. Pekarsky, Y., Hallas, C., Croce, C.M. JAMA (2001) [Pubmed]
  6. The protooncogene TCL1 is an Akt kinase coactivator. Laine, J., Künstle, G., Obata, T., Sha, M., Noguchi, M. Mol. Cell (2000) [Pubmed]
  7. Purification and characterization of recombinant forms of murine Tcl1 proteins. Du Bois, G.C., Song, S.P., Kulikovskaya, I., Rothstein, J.L., Germann, M.W., Croce, C.M. Protein Expr. Purif. (2000) [Pubmed]
  8. Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. Russo, G., Isobe, M., Gatti, R., Finan, J., Batuman, O., Huebner, K., Nowell, P.C., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines. Kiss, C., Nishikawa, J., Takada, K., Trivedi, P., Klein, G., Szekely, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Identification of the TCL1 gene involved in T-cell malignancies. Virgilio, L., Narducci, M.G., Isobe, M., Billips, L.G., Cooper, M.D., Croce, C.M., Russo, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  11. Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. Narducci, M.G., Pescarmona, E., Lazzeri, C., Signoretti, S., Lavinia, A.M., Remotti, D., Scala, E., Baroni, C.D., Stoppacciaro, A., Croce, C.M., Russo, G. Cancer Res. (2000) [Pubmed]
  12. Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas. Ramuz, O., Bouabdallah, R., Devilard, E., Borie, N., Groulet-Martinec, A., Bardou, V.J., Brousset, P., Bertucci, F., Birg, F., Birnbaum, D., Xerri, L. Int. J. Oncol. (2005) [Pubmed]
  13. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. Pekarsky, Y., Hallas, C., Isobe, M., Russo, G., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  14. Identification of Nerve Growth Factor-responsive Element of the TCL1 Promoter as a Novel Negative Regulatory Element. Hiromura, M., Suizu, F., Narita, M., Kinowaki, K., Noguchi, M. J. Biol. Chem. (2006) [Pubmed]
  15. A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane. French, S.W., Shen, R.R., Koh, P.J., Malone, C.S., Mallick, P., Teitell, M.A. Biochemistry (2002) [Pubmed]
  16. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Johnson, A.J., Lucas, D.M., Muthusamy, N., Smith, L.L., Edwards, R.B., De Lay, M.D., Croce, C.M., Grever, M.R., Byrd, J.C. Blood (2006) [Pubmed]
  17. Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines. Doerr, J.R., Malone, C.S., Fike, F.M., Gordon, M.S., Soghomonian, S.V., Thomas, R.K., Tao, Q., Murray, P.G., Diehl, V., Teitell, M.A., Wall, R. J. Mol. Biol. (2005) [Pubmed]
  18. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Herling, M., Patel, K.A., Teitell, M.A., Konopleva, M., Ravandi, F., Kobayashi, R., Jones, D. Blood (2008) [Pubmed]
  19. T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation. De Schouwer, P.J., Dyer, M.J., Brito-Babapulle, V.B., Matutes, E., Catovsky, D., Yuille, M.R. Br. J. Haematol. (2000) [Pubmed]
  20. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. Laine, J., Künstle, G., Obata, T., Noguchi, M. J. Biol. Chem. (2002) [Pubmed]
  21. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. Hoh, F., Yang, Y.S., Guignard, L., Padilla, A., Stern, M.H., Lhoste, J.M., van Tilbeurgh, H. Structure (1998) [Pubmed]
  22. Characterization and localization of the TCL-1 oncogene product. Fu, T.B., Virgilio, L., Narducci, M.G., Facchiano, A., Russo, G., Croce, C.M. Cancer Res. (1994) [Pubmed]
  23. TCL-1, MTCP-1 and TML-1 gene expression profile in non-leukemic clonal proliferations associated with ataxia-telangiectasia. Chun, H.H., Castellví-Bel, S., Wang, Z., Nagourney, R.A., Plaeger, S., Becker-Catania, S.G., Naeim, F., Sparkes, R.S., Gatti, R.A. Int. J. Cancer (2002) [Pubmed]
  24. Chromosome walking on the TCL1 locus involved in T-cell neoplasia. Virgilio, L., Isobe, M., Narducci, M.G., Carotenuto, P., Camerini, B., Kurosawa, N., Abbas-ar-Rushdi, n.u.l.l., Croce, C.M., Russo, G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  25. TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia. Narducci, M.G., Virgilio, L., Isobe, M., Stoppacciaro, A., Elli, R., Fiorilli, M., Carbonari, M., Antonelli, A., Chessa, L., Croce, C.M., Russo, G. Blood (1995) [Pubmed]
 
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