The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CBF2  -  Cbf2p

Saccharomyces cerevisiae S288c

Synonyms: CBF3A, CEP2, CSL5, CTF14, Centromere DNA-binding protein complex CBF3 subunit A, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Psychiatry related information on CBF2

 

High impact information on CBF2

 

Biological context of CBF2

 

Anatomical context of CBF2

  • We propose that a pathway involving Ndc10 might monitor defects in the mitotic apparatus independently of the Mad and Bub proteins [9].
 

Associations of CBF2 with chemical compounds

 

Physical interactions of CBF2

  • In the two-hybrid screen, Bir1p specifically interacts with Ndc10p, an essential component of the yeast kinetochore [8].
 

Enzymatic interactions of CBF2

 

Co-localisations of CBF2

 

Regulatory relationships of CBF2

 

Other interactions of CBF2

  • These data suggest that Cbf2p is an endogenous substrate of the CDC34 ubiquitin-conjugating enzyme and imply that ubiquitination of a kinetochore protein plays a regulatory role in kinetochore function [12].
  • Synthetic lethal interactions between a cep1 null mutation and mutations in either NDC10 or CEP3 were also detected [16].
  • Results of experiments using antibodies against Cbf2p and ubiquitin indicate that Cbf2p is ubiquitinated in vivo [12].
  • We show that a human homolog of SPT4 (HsSPT4) complements Scspt4-silencing defects and associates with ScCEN DNA in an Ndc10p-dependent manner [17].
  • In addition, Dam1p is associated preferentially with centromeric DNA as shown by chromatin immunoprecipitation experiments, and this association depends on Ndc10p/Cbf2p [13].
 

Analytical, diagnostic and therapeutic context of CBF2

References

  1. Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore. Jiang, W., Lechner, J., Carbon, J. J. Cell Biol. (1993) [Pubmed]
  2. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Goshima, G., Yanagida, M. Cell (2000) [Pubmed]
  3. Identification of essential components of the S. cerevisiae kinetochore. Doheny, K.F., Sorger, P.K., Hyman, A.A., Tugendreich, S., Spencer, F., Hieter, P. Cell (1993) [Pubmed]
  4. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Sassoon, I., Severin, F.F., Andrews, P.D., Taba, M.R., Kaplan, K.B., Ashford, A.J., Stark, M.J., Sorger, P.K., Hyman, A.A. Genes Dev. (1999) [Pubmed]
  5. Budding yeast centromere composition and assembly as revealed by in vivo cross-linking. Meluh, P.B., Koshland, D. Genes Dev. (1997) [Pubmed]
  6. Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation. Montpetit, B., Hazbun, T.R., Fields, S., Hieter, P. J. Cell Biol. (2006) [Pubmed]
  7. Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Jiang, W., Lim, M.Y., Yoon, H.J., Thorner, J., Martin, G.S., Carbon, J. Mol. Gen. Genet. (1995) [Pubmed]
  8. Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Yoon, H.J., Carbon, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Role of the kinetochore protein Ndc10 in mitotic checkpoint activation in Saccharomyces cerevisiae. Fraschini, R., Beretta, A., Lucchini, G., Piatti, S. Mol. Genet. Genomics (2001) [Pubmed]
  10. Genetic evidence for a role of phospholipase C at the budding yeast kinetochore. DeLillo, N., Romero, C., Lin, H., Vancura, A. Mol. Genet. Genomics (2003) [Pubmed]
  11. Phospholipase C is involved in kinetochore function in Saccharomyces cerevisiae. Lin, H., Choi, J.H., Hasek, J., DeLillo, N., Lou, W., Vancura, A. Mol. Cell. Biol. (2000) [Pubmed]
  12. Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Yoon, H.J., Carbon, J. Mol. Cell. Biol. (1995) [Pubmed]
  13. Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle. Jones, M.H., He, X., Giddings, T.H., Winey, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  14. Isolation and characterization of KIUBP2, a ubiquitin hydrolase gene of Kluyveromyces lactis that can suppress a ts-mutation in CBF2, a gene encoding a centromeric protein of Saccharomyces cerevisiae. Winkler, A.A., Korstanje, R., Zonneveld, B.J., Hooykaas, P.J., Steensma, H.Y. Curr. Genet. (2000) [Pubmed]
  15. Phosphorylation of the chromosomal passenger protein Bir1 is required for localization of Ndc10 to the spindle during anaphase and full spindle elongation. Widlund, P.O., Lyssand, J.S., Anderson, S., Niessen, S., Yates, J.R., Davis, T.N. Mol. Biol. Cell (2006) [Pubmed]
  16. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Meluh, P.B., Koshland, D. Mol. Biol. Cell (1995) [Pubmed]
  17. Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae. Crotti, L.B., Basrai, M.A. EMBO J. (2004) [Pubmed]
  18. Analysis of the distribution of the kinetochore protein Ndc10p in Saccharomyces cerevisiae using 3-D modeling of mitotic spindles. Müller-Reichert, T., Sassoon, I., O'Toole, E., Romao, M., Ashford, A.J., Hyman, A.A., Antony, C. Chromosoma (2003) [Pubmed]
 
WikiGenes - Universities