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PDXK  -  pyridoxal (pyridoxine, vitamin B6) kinase

Homo sapiens

Synonyms: C21orf124, C21orf97, FLJ21324, FLJ31940, HEL-S-1a, ...
 
 
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Disease relevance of PDXK

 

High impact information on PDXK

 

Chemical compound and disease context of PDXK

 

Biological context of PDXK

 

Anatomical context of PDXK

  • The mean PNK activity in red blood cells from black subjects was only about 40% of that in whites [12].
  • Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis [10].
  • Comparison of the differential expressions of PKH and PKH-T in testes of different developmental stages indicated that PKH-T was expressed in the adult testis and spermatozoa, while PKH, in the adult, fetal and aged testes [10].
  • Previous studies, employing cell-free systems, have suggested that hPNK participates in the repair of DNA strand breaks [4].
  • Alternatively, macrophages were preloaded with the lysosomal tracer FITC-dextran before membrane labeling with PKH and incubation with latex beads [13].
 

Associations of PDXK with chemical compounds

 

Other interactions of PDXK

 

Analytical, diagnostic and therapeutic context of PDXK

References

  1. Human pyridoxal kinase: overexpression and properties of the recombinant enzyme. Lee, H.S., Moon, B.J., Choi, S.Y., Kwon, O.S. Mol. Cells (2000) [Pubmed]
  2. Erythrocyte pyridoxine kinase levels in patients with sideroblastic anemia. Chillar, R.K., Johnson, C.S., Beutler, E. N. Engl. J. Med. (1976) [Pubmed]
  3. Low erythrocyte pyridoxal-kinase activity in Blacks: Its possible relation to falciparum malaria. Martin, S.K., Miller, L.H., Kark, J.A., Hicks, C.U., Haut, M.J., Okoye, V.C., Esan, G.J. Lancet (1978) [Pubmed]
  4. Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents. Rasouli-Nia, A., Karimi-Busheri, F., Weinfeld, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. A novel role of circadian transcription factor DBP in hippocampal plasticity. Klugmann, M., Leichtlein, C.B., Symes, C.W., Klaussner, B.C., Brooks, A.I., Young, D., During, M.J. Mol. Cell. Neurosci. (2006) [Pubmed]
  6. Pyridoxal kinase: decreased activity in red blood cells of Afro-Americans. Chern, C.J., Beutler, E. Science (1975) [Pubmed]
  7. Pyridoxal kinase knockout of Dictyostelium complemented by the human homologue. Guo, K., Newell, P.C. FEMS Microbiol. Lett. (2000) [Pubmed]
  8. Evolutionary breakpoints on human chromosome 21. Davisson, M.T., Bechtel, L.J., Akeson, E.C., Fortna, A., Slavov, D., Gardiner, K. Genomics (2001) [Pubmed]
  9. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Wiltshire, T., Pletcher, M., Cole, S.E., Villanueva, M., Birren, B., Lehoczky, J., Dewar, K., Reeves, R.H. Genome Res. (1999) [Pubmed]
  10. Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis. Fang, X., Zhou, Z.M., Lu, L., Yin, L.L., Li, J.M., Zhen, Y., Wang, H., Sha, J.H. Asian J. Androl. (2004) [Pubmed]
  11. Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex. Mani, R.S., Karimi-Busheri, F., Fanta, M., Cass, C.E., Weinfeld, M. Biochemistry (2003) [Pubmed]
  12. Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans. Chern, C.J., Beutler, E. Am. J. Hum. Genet. (1976) [Pubmed]
  13. Quantitative analysis of phagolysosome fusion in intact cells: inhibition by mycobacterial lipoarabinomannan and rescue by an 1alpha,25-dihydroxyvitamin D3-phosphoinositide 3-kinase pathway. Hmama, Z., Sendide, K., Talal, A., Garcia, R., Dobos, K., Reiner, N.E. J. Cell. Sci. (2004) [Pubmed]
  14. Bone marrow delta-aminolaevulinate synthase deficiency in a female with congenital sideroblastic anemia. Buchanan, G.R., Bottomley, S.S., Nitschke, R. Blood (1980) [Pubmed]
  15. Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum. Wrenger, C., Eschbach, M.L., Müller, I.B., Warnecke, D., Walter, R.D. J. Biol. Chem. (2005) [Pubmed]
  16. Vitamin B-6 supplementation and theophylline-related effects in humans. Bartel, P.R., Ubbink, J.B., Delport, R., Lotz, B.P., Becker, P.J. Am. J. Clin. Nutr. (1994) [Pubmed]
  17. Activities of the hepatic enzymes of vitamin B6 metabolism for patients with cirrhosis. Merrill, A.H., Henderson, J.M., Wang, E., Codner, M.A., Hollins, B., Millikan, W.J. Am. J. Clin. Nutr. (1986) [Pubmed]
  18. Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase. Kang, J.H., Hong, M.L., Kim, D.W., Park, J., Kang, T.C., Won, M.H., Baek, N.I., Moon, B.J., Choi, S.Y., Kwon, O.S. Eur. J. Biochem. (2004) [Pubmed]
  19. Physical properties of human polynucleotide kinase: hydrodynamic and spectroscopic studies. Mani, R.S., Karimi-Busheri, F., Cass, C.E., Weinfeld, M. Biochemistry (2001) [Pubmed]
  20. Production and characterization of monoclonal antibodies to porcine brain pyridoxal kinase. Choi, S.Y., Kwok, F., Bahn, J.H., Jeon, S.G., Ahn, Y.K., Yoon, B.H., Lee, B.R., Choi, K.S., Gao, G.Z. Biofactors (1999) [Pubmed]
  21. A novel approach to the measurement of different in vitro leukaemic cell growth parameters: the use of PKH GL fluorescent probes. Ashley, D.M., Bol, S.J., Waugh, C., Kannourakis, G. Leuk. Res. (1993) [Pubmed]
 
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