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EIF4A3  -  eukaryotic translation initiation factor 4A3

Homo sapiens

Synonyms: ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DDX48, DEAD box protein 48, EIF4AIII, ...
 
 
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Disease relevance of EIF4A3

 

High impact information on EIF4A3

 

Associations of EIF4A3 with chemical compounds

  • Treatment with the proteasome inhibitor MG132 led to accumulation of GFP-eIF4A-III mainly in the nucleolus, suggesting that transition of eIF4A-III between subnuclear domains and/or accumulation in nuclear speckles is controlled by proteolysis-labile factors [5].
 

Biological context of EIF4A3

  • In mammalian cells, eIF4AIII is essential for nonsense-mediated mRNA decay (NMD) [6].
  • Mutations in the canonical Walker A and B motifs that eliminate RNA-dependent ATP hydrolysis by eIF4AIII in vitro are of no detectable consequence for EJC formation and NMD activation [7].
 

Anatomical context of EIF4A3

 

Physical interactions of EIF4A3

  • An additional eIF4AIII-specific motif forms part of the binding site for MLN51, another EJC core component [7].
 

Regulatory relationships of EIF4A3

 

Other interactions of EIF4A3

 

Analytical, diagnostic and therapeutic context of EIF4A3

References

  1. Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer. Xia, Q., Kong, X.T., Zhang, G.A., Hou, X.J., Qiang, H., Zhong, R.Q. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Lee, S., Baek, M., Yang, H., Bang, Y.J., Kim, W.H., Ha, J.H., Kim, D.K., Jeoung, D.I. Cancer Lett. (2002) [Pubmed]
  3. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Bono, F., Ebert, J., Lorentzen, E., Conti, E. Cell (2006) [Pubmed]
  4. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Li, Q., Imataka, H., Morino, S., Rogers, G.W., Richter-Cook, N.J., Merrick, W.C., Sonenberg, N. Mol. Cell. Biol. (1999) [Pubmed]
  5. Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia. Koroleva, O.A., Calder, G., Pendle, A.F., Kim, S.H., Lewandowska, D., Simpson, C.G., Jones, I.M., Brown, J.W., Shaw, P.J. Plant. Cell (2009) [Pubmed]
  6. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Shibuya, T., Tange, T.Ø., Sonenberg, N., Moore, M.J. Nat. Struct. Mol. Biol. (2004) [Pubmed]
  7. Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. Shibuya, T., Tange, T.Ø., Stroupe, M.E., Moore, M.J. RNA (2006) [Pubmed]
  8. A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. Holzmann, K., Gerner, C., Pöltl, A., Schäfer, R., Obrist, P., Ensinger, C., Grimm, R., Sauermann, G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. MLN51 Stimulates the RNA-Helicase Activity of eIF4AIII. Noble, C.G., Song, H. PLoS ONE (2007) [Pubmed]
  10. eIF4A3 is a novel component of the exon junction complex. Chan, C.C., Dostie, J., Diem, M.D., Feng, W., Mann, M., Rappsilber, J., Dreyfuss, G. RNA (2004) [Pubmed]
 
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