The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

OSBPL2  -  oxysterol binding protein-like 2

Homo sapiens

Synonyms: DFNA67, KIAA0772, ORP-2, ORP2, OSBP-related protein 2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on OSBPL2

  • Together, the biochemical, genetic, and molecular data verify the identity of orp1 and orp2 as duplicate structural genes for the beta subunit of tryptophan synthase [1].
  • The cloned genes were mapped by restriction fragment length polymorphism analysis to approximately the same chromosomal locations as the genetically mapped factors orp1 and orp2 [1].
  • Phenotypes associated with overexpression of ORP2 in yeast were a dramatic decrease in cell growth and a block in Golgi-derived vesicle transport distinct from that of ORP1 [2].
  • At least three genic rearrangements differentiate the maize Orp1 and Orp2 segments, including an insertion of a single gene and two deletions that removed one gene each, while no genic rearrangements were detected in the maize Orp2 region relative to sorghum [3].
  • All of the genes encode a pleckstrin homology domain, except OSBPL2 [4].
 

Biological context of OSBPL2

 

Anatomical context of OSBPL2

 

Associations of OSBPL2 with chemical compounds

  • Our results suggest a function of ORP2 in both cholesterol trafficking and control of endocytic membrane transport [5].
  • The ORP2-expressing cells also have a reduced level of triacylglycerols [6].
 

Other interactions of OSBPL2

  • However, two of the peptides, OSBPL2 and OSBPL1A, consist of the OSBP domain only [4].
  • ORP2 [OSBP (oxysterol-binding protein)-related protein 2] belongs to the 12-member mammalian ORP gene/protein family [5].

References

  1. The maize auxotrophic mutant orange pericarp is defective in duplicate genes for tryptophan synthase beta. Wright, A.D., Moehlenkamp, C.A., Perrot, G.H., Neuffer, M.G., Cone, K.C. Plant Cell (1992) [Pubmed]
  2. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. Xu, Y., Liu, Y., Ridgway, N.D., McMaster, C.R. J. Biol. Chem. (2001) [Pubmed]
  3. DNA rearrangement in orthologous orp regions of the maize, rice and sorghum genomes. Ma, J., SanMiguel, P., Lai, J., Messing, J., Bennetzen, J.L. Genetics (2005) [Pubmed]
  4. A family of 12 human genes containing oxysterol-binding domains. Jaworski, C.J., Moreira, E., Li, A., Lee, R., Rodriguez, I.R. Genomics (2001) [Pubmed]
  5. Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis. Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E., Olkkonen, V.M. Biochem. J. (2005) [Pubmed]
  6. Overexpression of OSBP-related protein 2 (ORP2) in CHO cells induces alterations of phospholipid species composition. Käkelä, R., Tanhuanpää, K., Laitinen, S., Somerharju, P., Olkkonen, V.M. Biochem. Cell Biol. (2005) [Pubmed]
 
WikiGenes - Universities