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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Novel neurotrophin-1/ B cell-stimulating factor-3: a cytokine of the IL-6 family.

We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/ B cell-stimulating factor-3 ( NNT-1/ BSF-3). NNT-1/ BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/ BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/ BSF-3 also was identified, which shows 96% homology to human NNT-1/ BSF-3. NNT-1/ BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/ BSF-3 induces tyrosine phosphorylation of glycoprotein 130 ( gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuroblastoma cells. NNT-1/ BSF-3 shows activities typical of IL-6 family members. In vitro, it supports the survival of chicken embryo motor and sympathetic neurons. In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. NNT-1/ BSF-3 is a gp130 activator with B-cell stimulating capability.[1]

References

  1. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Senaldi, G., Varnum, B.C., Sarmiento, U., Starnes, C., Lile, J., Scully, S., Guo, J., Elliott, G., McNinch, J., Shaklee, C.L., Freeman, D., Manu, F., Simonet, W.S., Boone, T., Chang, M.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
 
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