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MeSH term: ... Disease relevance of Genes, BRCA1 Mutations and polymorphisms in the familial early- onset breast cancer( BRCA1) gene. Breast Cancer Information Core. In previous work from our laboratory, one or more...( BRCA1) on chromosome 17. High impact information on Genes, BRCA1 The BRCA1 gene product and its... / Synonyms: BRCA1 Gene; BRCA1 Genes; Gene, BRCA1
Rattus norvegicus
Gene: ... Disease relevance of Brca1 Using this polymorphic marker, we also investigated the loss of heterozygosity( LOH) of the Brca1 microsatellite marker in carcinogen- or radiation- induced mammary carcinomas... intravenous injection of MNU( 50 mg/ kg body weight). High impact information on Brca1 We show here...
Homo sapiens
Gene: ... Disease relevance of BRCA1P1 In the two families with breast and ovarian cancer mentioned above, distinct homologous recombination events occurred between intron 2 of BRCA1 and intron 2 of PsiBRCA1, leading to 37- kb deletions. High impact information on BRCA1P1 Like BRCA1, BRCA2 behaves as a dominantly... / Synonyms: PsiBRCA1; pseudo-BRCA1
Homo sapiens
Gene: ... that is a binding partner of the breast cancer tumor suppressor BRCA1. Moreover, in human cells exposed to mitomycin...) basic region leucine zipper factors. Mutational analysis of the LMO4 gene, encoding a BRCA1- interacting... are low- penetrance breast cancer susceptibility alleles. The BRCA1- interacting helicase BRIP1... / Synonyms: BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1
Homo sapiens
Gene: ... and BRCA2 genes -- in at least 5% to 10% of all epithelial ovarian cancers. The BRCA1- interacting helicase... checkpoint. Mutations in the BRCA1( ref. 1) tumour suppressor gene are found in almost all of the families... DNA damage in the BRCA1- mutated cell line HCC1937. Nearly all BRCA1 germ- line mutations involve...
Mus musculus
Gene: ... Disease relevance of Brca1 Furthermore, inactivation of Chk2 and Brca1 was cooperative in breast... mutation of the Chk2 phosphorylation site in Brca1. We developed genetically defined primary mouse ovarian surface epithelial( OSE) cell lines in which the loss of functional Brca1 and p53 recapitulates the events...
Homo sapiens
Gene: ... to CA125, an ovarian tumor antigen used in monitoring ovarian cancer. Expression of BRCA1, NBR1 and NBR2... BRCA1 and NBR2 genes and the homologous Brcal and Nbr1 mouse genes are situated head- to- head on human... copies of BRCA1 exons 1 and 2, of exons 1 and 3 of the adjacent 1A1- 3B gene and of the previously... / Synonyms: Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein
Homo sapiens
Gene: ... Disease relevance of BAP1 BAP1 binds to the wild- type BRCA1- RING finger, but not to germline mutants of the BRCA1- RING finger found in breast cancer kindreds. We have identified a novel protein, BAP..., BRCA1. Of those patients undergoing regular mammographic screening, 100% of BRCA2- associated... / Synonyms: BRCA1-associated protein 1
Homo sapiens
Gene: ... Disease relevance of BRAP CONCLUSIONS: BRCA1, as well as TP53, can undergo LOH prior to stromal invasion in BRCA1- associated ovarian cancer. Patients with BRCA1- associated breast cancer had twice... cancer was four to five times as frequent as in the sporadic group( p< 0. 001). BRCA1- associated breast... / Synonyms: BRCA1-associated protein
Gallus gallus
Gene: ... Disease relevance of BRCA1 The breast cancer susceptibility gene BRCA1 encodes a multifunctional protein that is mutated in many hereditary breast and ovarian cancers. High impact information on BRCA1... recently found to be components of BRCA1- associated genome surveillance complex( BASC ), a supercomplex...
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Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
