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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH term: ... Disease relevance of Genes, BRCA1 Mutations and polymorphisms in the familial early- onset breast cancer( BRCA1) gene. Breast Cancer Information Core. In previous work from our laboratory, one or more...( BRCA1) on chromosome 17. High impact information on Genes, BRCA1 The BRCA1 gene product and its... / Synonyms: BRCA1 Gene; BRCA1 Genes; Gene, BRCA1
Rattus norvegicus
Gene: ... Disease relevance of Brca1 Using this polymorphic marker, we also investigated the loss of heterozygosity( LOH) of the Brca1 microsatellite marker in carcinogen- or radiation- induced mammary carcinomas... intravenous injection of MNU( 50 mg/ kg body weight). High impact information on Brca1 We show here...
Homo sapiens
Gene: ... Disease relevance of BRCA1P1 In the two families with breast and ovarian cancer mentioned above, distinct homologous recombination events occurred between intron 2 of BRCA1 and intron 2 of PsiBRCA1, leading to 37- kb deletions. High impact information on BRCA1P1 Like BRCA1, BRCA2 behaves as a dominantly... / Synonyms: PsiBRCA1; pseudo-BRCA1
Homo sapiens
Gene: ... that is a binding partner of the breast cancer tumor suppressor BRCA1. Moreover, in human cells exposed to mitomycin...) basic region leucine zipper factors. Mutational analysis of the LMO4 gene, encoding a BRCA1- interacting... are low- penetrance breast cancer susceptibility alleles. The BRCA1- interacting helicase BRIP1... / Synonyms: BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1
Homo sapiens
Gene: ... and BRCA2 genes -- in at least 5% to 10% of all epithelial ovarian cancers. The BRCA1- interacting helicase... checkpoint. Mutations in the BRCA1( ref. 1) tumour suppressor gene are found in almost all of the families... DNA damage in the BRCA1- mutated cell line HCC1937. Nearly all BRCA1 germ- line mutations involve...
Mus musculus
Gene: ... Disease relevance of Brca1 Furthermore, inactivation of Chk2 and Brca1 was cooperative in breast... mutation of the Chk2 phosphorylation site in Brca1. We developed genetically defined primary mouse ovarian surface epithelial( OSE) cell lines in which the loss of functional Brca1 and p53 recapitulates the events...
Homo sapiens
Gene: ... to CA125, an ovarian tumor antigen used in monitoring ovarian cancer. Expression of BRCA1, NBR1 and NBR2... BRCA1 and NBR2 genes and the homologous Brcal and Nbr1 mouse genes are situated head- to- head on human... copies of BRCA1 exons 1 and 2, of exons 1 and 3 of the adjacent 1A1- 3B gene and of the previously... / Synonyms: Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein
Homo sapiens
Gene: ... Disease relevance of BAP1 BAP1 binds to the wild- type BRCA1- RING finger, but not to germline mutants of the BRCA1- RING finger found in breast cancer kindreds. We have identified a novel protein, BAP..., BRCA1. Of those patients undergoing regular mammographic screening, 100% of BRCA2- associated... / Synonyms: BRCA1-associated protein 1
Homo sapiens
Gene: ... Disease relevance of BRAP CONCLUSIONS: BRCA1, as well as TP53, can undergo LOH prior to stromal invasion in BRCA1- associated ovarian cancer. Patients with BRCA1- associated breast cancer had twice... cancer was four to five times as frequent as in the sporadic group( p< 0. 001). BRCA1- associated breast... / Synonyms: BRCA1-associated protein
Gallus gallus
Gene: ... Disease relevance of BRCA1 The breast cancer susceptibility gene BRCA1 encodes a multifunctional protein that is mutated in many hereditary breast and ovarian cancers. High impact information on BRCA1... recently found to be components of BRCA1- associated genome surveillance complex( BASC ), a supercomplex...


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