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Gene Review

Brca1  -  breast cancer 1, early onset

Rattus norvegicus

Synonyms: Breast cancer type 1 susceptibility protein homolog
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Disease relevance of Brca1


High impact information on Brca1

  • We show here that the conversion of OPCs to NSLCs depends on the reactivation of the sox2 gene, which in turn depends on the recruitment of the tumor suppressor protein Brca1 and the chromatin-remodeling protein Brahma (Brm) to an enhancer in the sox2 promoter [6].
  • Breast cancer and thyroid therapy. Statement by the American Thyroid Association [7].
  • However, no variation in Brca1 or Brca2 protein expression was demonstrated, whatever the experimental conditions were [8].
  • Breast cancer is the leading cause of cancer death in women in the industrialized world, and the rates of breast cancer incidence are rising [9].
  • The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk [10].

Chemical compound and disease context of Brca1

  • These results suggest that obesity in postmenopausal women may increase breast cancer risk due to increased breast tissue exposure to adipose tissue-derived estrogen [4].

Biological context of Brca1


Anatomical context of Brca1

  • Rat Brca1 mRNA was expressed in most tissues studied with the highest level in testis, consistent with studies in human and mouse [1].
  • Previous work reported the differential expression of annexin I mRNA among rat adenocarcinoma cell lines of various metastatic potential (MTLn3, MTLn2, MTC.4: highest to lowest, respectively) (Pencil et al. 1993, Breast Cancer Res Treat, 25, 165-74) [13].

Associations of Brca1 with chemical compounds


Analytical, diagnostic and therapeutic context of Brca1


  1. Cloning, genetic mapping and expression studies of the rat Brca1 gene. Chen, K.S., Shepel, L.A., Haag, J.D., Heil, G.M., Gould, M.N. Carcinogenesis (1996) [Pubmed]
  2. Genetic and hormonal risk factors in breast cancer. Martin, A.M., Weber, B.L. J. Natl. Cancer Inst. (2000) [Pubmed]
  3. Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals. Figge, M.A., Blankenship, L. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  4. Obesity increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in an ovariectomized Zucker rat model. Hakkak, R., Macleod, S., Shaaf, S., Holley, A.W., Simpson, P., Fuchs, G., Jo, C.H., Kieber-Emmons, T., Korourian, S. Int. J. Oncol. (2007) [Pubmed]
  5. Detection of VIP receptors in MNU-induced breast cancer in rats: implications for breast cancer targeting. Dagar, S., Sekosan, M., Rubinstein, I., Onyüksel, H. Breast Cancer Res. Treat. (2001) [Pubmed]
  6. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Kondo, T., Raff, M. Genes Dev. (2004) [Pubmed]
  7. Breast cancer and thyroid therapy. Statement by the American Thyroid Association. Gorman, C.A., Becker, D.V., Greenspan, F.S., Levy, R.P., Oppenheimer, J.H., Rivlin, R.S., Robbins, J., Vanderlaan, W.P. JAMA (1977) [Pubmed]
  8. Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. Vissac-Sabatier, C., Coxam, V., Déchelotte, P., Picherit, C., Horcajada, M.N., Davicco, M.J., Lebecque, P., Bignon, Y.J., Bernard-Gallon, D. Cancer Res. (2003) [Pubmed]
  9. Electric power, pineal function, and the risk of breast cancer. Stevens, R.G., Davis, S., Thomas, D.B., Anderson, L.E., Wilson, B.W. FASEB J. (1992) [Pubmed]
  10. Compensatory mammary growth following protein restriction during pregnancy and lactation increases early-onset mammary tumor incidence in rats. Fernandez-Twinn, D.S., Ekizoglou, S., Gusterson, B.A., Luan, J., Ozanne, S.E. Carcinogenesis (2007) [Pubmed]
  11. Sequence analysis of the rat Brca1 homolog and its promoter region. Bennett, L.M., Brownlee, H.A., Hagavik, S., Wiseman, R.W. Mamm. Genome (1999) [Pubmed]
  12. Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. Dimitrov, S., Brennerova, M., Forejt, J. Gene (2001) [Pubmed]
  13. Elevated levels of annexin I protein in vitro and in vivo in rat and human mammary adenocarcinoma. Pencil, S.D., Toth, M. Clin. Exp. Metastasis (1998) [Pubmed]
  14. Val(659)-->Glu mutation within the transmembrane domain of ErbB-2: effects measured by (2)H NMR in fluid phospholipid bilayers. Sharpe, S., Barber, K.R., Grant, C.W. Biochemistry (2000) [Pubmed]
  15. Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen. Brown, K. Expert opinion on drug safety. (2002) [Pubmed]
  16. Breast cancer imaging with PET and SPECT agents: an in vivo comparison. Palmedo, H., Hensel, J., Reinhardt, M., Von Mallek, D., Matthies, A., Biersack, H.J. Nucl. Med. Biol. (2002) [Pubmed]
  17. Histone H1 modulates immune status in experimental breast cancer. Vani, G., Devipriya, S., Shyamaladevi, C.S. Chemotherapy. (2003) [Pubmed]
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