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MeSH Review:

Genes, BRCA1

Swami, S. et al., Dai, Q. et al., Touitou, I. et al., Freneaux, P. et al., Chamberlain, J.S. et al., et al.

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Disease relevance of Genes, BRCA1

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core [1].
In previous work from our laboratory, one or more deleted regions were found in prostate tumors distal to the breast and ovarian cancer susceptibility gene (BRCA1) on chromosome 17 [2].

High impact information on Genes, BRCA1

The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage [3].
These markers define the location of a gene (BRCA1) which appears to be inherited as an autosomal dominant susceptibility allele [4].
Induction of progesterone receptor by E2 is suppressed by 1,25(OH)2D3, and the E2-mediated increase in breast cancer susceptibility gene (BRCA1) protein is reduced by 1,25(OH)2D3 treatment [5].
Our series were composed of 16 cases of breast carcinoma in women with a germline Brca1 gene mutation, and of four cases with Brca2 mutation [6].

Biological context of Genes, BRCA1

17 beta Hydroxysteroid dehydrogenase 1 "pseudogene" is differentially transcribed: still a candidate for the breast-ovarian cancer susceptibility gene (BRCA1) [7].

References

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core. Couch, F.J., Weber, B.L. Hum. Mutat. (1996) [Pubmed]
A common deletion at chromosomal region 17q21 in sporadic prostate tumors distal to BRCA1. Dai, Q., Deubler, D.A., Maxwell, T.M., Zhu, X.L., Cui, J., Rohr, L.R., Stephenson, R.A., Brothman, A.R. Genomics (2001) [Pubmed]
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Greenberg, R.A., Sobhian, B., Pathania, S., Cantor, S.B., Nakatani, Y., Livingston, D.M. Genes Dev. (2006) [Pubmed]
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Chamberlain, J.S., Boehnke, M., Frank, T.S., Kiousis, S., Xu, J., Guo, S.W., Hauser, E.R., Norum, R.A., Helmbold, E.A., Markel, D.S. Am. J. Hum. Genet. (1993) [Pubmed]
1alpha,25-Dihydroxyvitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cells. Swami, S., Krishnan, A.V., Feldman, D. Clin. Cancer Res. (2000) [Pubmed]
Low expression of bcl-2 in Brca1-associated breast cancers. Freneaux, P., Stoppa-Lyonnet, D., Mouret, E., Kambouchner, M., Nicolas, A., Zafrani, B., Vincent-Salomon, A., Fourquet, A., Magdelenat, H., Sastre-Garau, X. Br. J. Cancer (2000) [Pubmed]
17 beta Hydroxysteroid dehydrogenase 1 "pseudogene" is differentially transcribed: still a candidate for the breast-ovarian cancer susceptibility gene (BRCA1). Touitou, I., Cai, Q.Q., Rochefort, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]

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