Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BRCA1 - breast cancer 1, early onset

Gallus gallus

Wang, W. et al., Orelli, B.J. et al.

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Disease relevance of BRCA1

The breast cancer susceptibility gene BRCA1 encodes a multifunctional protein that is mutated in many hereditary breast and ovarian cancers [1].

High impact information on BRCA1

The genes responsible for BS and A-T have been identified as BLM and ATM, respectively, whose products were recently found to be components of BRCA1-associated genome surveillance complex (BASC), a supercomplex possibly involved in the recognition and repair of aberrant DNA structures [2].

References

Nine novel conserved motifs in BRCA1 identified by the chicken orthologue. Orelli, B.J., Logsdon Jr, J.M., Bishop, D.K. Oncogene (2001) [Pubmed]
The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells. Wang, W., Seki, M., Otsuki, M., Tada, S., Takao, N., Yamamoto, K., Hayashi, M., Honma, M., Enomoto, T. Biochim. Biophys. Acta (2004) [Pubmed]

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