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Gene Review

BRCA1  -  breast cancer 1, early onset

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Disease relevance of BRCA1


High impact information on BRCA1

  • The genes responsible for BS and A-T have been identified as BLM and ATM, respectively, whose products were recently found to be components of BRCA1-associated genome surveillance complex (BASC), a supercomplex possibly involved in the recognition and repair of aberrant DNA structures [2].


  1. Nine novel conserved motifs in BRCA1 identified by the chicken orthologue. Orelli, B.J., Logsdon Jr, J.M., Bishop, D.K. Oncogene (2001) [Pubmed]
  2. The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells. Wang, W., Seki, M., Otsuki, M., Tada, S., Takao, N., Yamamoto, K., Hayashi, M., Honma, M., Enomoto, T. Biochim. Biophys. Acta (2004) [Pubmed]
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