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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 329 documents. Results 1 - 10.

Rattus norvegicus
Gene: ... Disease relevance of E2f1 Transactivation of E2F- regulated genes by polyomavirus large T antigen: evidence for a two- step mechanism. These results suggest that cyclin E, cdk2, cdk5 and E2F- 1 play... by the coinjection of SV40 T- antigen, adenovirus E1A, or a high level of E2F- 1 expression plasmids. We thus... / Synonyms: E2F-1; Transcription factor E2F1
Homo sapiens
Gene: ... with the E2F- 1 transactivation domain. All the cyclin A binding E2F family members can interact...Disease relevance of E2F1 E2F1 was the only family member more abundant in the melanoma cells..., the endogenous cyclin E gene is activated following expression of the E2F1 product encoded by a recombinant... / Synonyms: E2F-1; Transcription factor E2F1; pRB-binding protein E2F-1
Mus musculus
Gene: ... Disease relevance of E2f1 Emu- Myc transgenic mice lacking one or both E2f1 alleles exhibited...- Myc, E2f1, and a combination of the two was driven by the albumin promoter. Two mutant Rb promoter... information on E2f1 Levels of E2F1 protein were greater in the nucleus of neurons in brains of HIV- infected... / Synonyms: E2F-1; Transcription factor E2F1
Arabidopsis thaliana
Gene: ... High impact information on E2F1 The role of the Arabidopsis E2FB transcription factor in regulating... by E2FB. Biological context of E2F1 Both AtE2F1 and AtE2F3 were translocated to the nucleus... transactivation of AtE2F1 and AtE2F3 is DPa specific and nuclear import dependent. Associations of E2F1... / Synonyms: E2F TRANSCRIPTION FACTOR-1 E2F1
Gallus gallus
Gene: ... High impact information on E2F1 Alterations in p53 and E2F- 1 function common to immortalized chicken embryo fibroblasts. The biological effects of differentially regulated p53 and E2F- 1 were... of the expression patterns of down- stream genes. In this system very high levels of E2F1 overexpression cause...
Drosophila melanogaster
Gene: ... analyzed in detail. dE2F1( su89) is a novel allele of dE2F1 that disrupts dE2F1' s association with RBF... phenotype. High impact information on E2f Negative regulation of dE2F1 by cyclin- dependent kinases controls cell cycle timing. Without dE2F1, the compensatory mechanism fails, and treatments that alter Cdk... / Synonyms: DmE2F-1; E2F-1; E2F1
MeSH term: ... that overexpression of the E2F1 complementary DNA can activate DNA synthesis in cells that would otherwise growth... enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all...
MeSH term: ... that phosphorylation of E2F- 1 is important in the regulation of its activity during the cell cycle and during...
Homo sapiens
Gene: ... Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: prognostic significance of E2F- 1... of the complex is part of the mechanism by which E1A inactivates RB function. Conversely, E2F- 1 overrode an RB... elicited by RB1CC1, whereas E2F1 was not affected. Southern blot analyses with p16( INK4A)( CDKN2A; 9p21...
Homo sapiens
Gene: ... ) of Guam have new implications for global health? Although E2F1 can bind DNA as a homodimer and increase.../ H48Q). Approximately 10% of all familial cases of amyotrophic lateral sclerosis( fALS) are linked... and glutathione content, which remained at similar levels in the 2 cell lines for all times studied, appeared...


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