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Gene Review

E2f  -  E2F transcription factor

Drosophila melanogaster

Synonyms: CG6376, DRTF1/E2F, DmE2F-1, Dmel\CG6376, Dp, ...
 
 
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Disease relevance of E2f

 

High impact information on E2f

 

Biological context of E2f

 

Anatomical context of E2f

 

Associations of E2f with chemical compounds

  • This replication inhibition could be overcome by the kinase inhibitor 6-dimethylaminopurine (6-DMAP), but not by expression of subunits of the transcription factor E2F [14].
  • This study suggests that, in fruit fly embryos, 1) there is a dose-dependent relationship between cell cycle length and O2 levels in fruit fly embryos, and 2) stabilized cyclin A and E2F1 are likely to be the mediators of hypoxia-induced arrest at metaphase and pre-S phase [15].
 

Physical interactions of E2f

  • In this study, we found three potential Caudal binding sequences in the 5'-flanking region of the Drosophila E2F (DE2F) gene and showed by transient transfection assays that they are involved in Caudal transactivation of the dE2F gene promoter [16].
  • We show that a Drosophila DP protein which can interact co-operatively with E2F proteins is a physiological DNA binding component of Drosophila DRTF1/E2F [17].
  • Cdc2 binds to E2F in vitro, and post-transcriptionally promotes its accumulation in vivo [18].
 

Regulatory relationships of E2f

 

Other interactions of E2f

  • Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program [7].
  • Instead, dE2F/RBF-mediated repression is exerted on genes that encode an assortment of cellular functions, and these effects are reversed on sets of functionally related genes in particular developmental contexts [6].
  • More over, RBF2 and dE2F2 act synergistically to antagonize dE2F1-mediated activation, and they co-operate to block S phase progression in transgenic animals [21].
  • These results suggest that Caudal is involved in regulation of proliferation through transactivation of the E2F gene in Drosophila [16].
  • This regulation of the VG-SD activity by dE2F1 is dependent on the vg genetic background [22].

References

  1. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. Weng, L., Zhu, C., Xu, J., Du, W. EMBO J. (2003) [Pubmed]
  2. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. Du, W., Xie, J.E., Dyson, N. EMBO J. (1996) [Pubmed]
  3. Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Reis, T., Edgar, B.A. Cell (2004) [Pubmed]
  4. Coordination of growth and cell division in the Drosophila wing. Neufeld, T.P., de la Cruz, A.F., Johnston, L.A., Edgar, B.A. Cell (1998) [Pubmed]
  5. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Frolov, M.V., Stevaux, O., Moon, N.S., Dimova, D., Kwon, E.J., Morris, E.J., Dyson, N.J. Genes Dev. (2003) [Pubmed]
  6. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Dimova, D.K., Stevaux, O., Frolov, M.V., Dyson, N.J. Genes Dev. (2003) [Pubmed]
  7. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Royzman, I., Whittaker, A.J., Orr-Weaver, T.L. Genes Dev. (1997) [Pubmed]
  8. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Duronio, R.J., Bonnette, P.C., O'Farrell, P.H. Mol. Cell. Biol. (1998) [Pubmed]
  9. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Cayirlioglu, P., Ward, W.O., Silver Key, S.C., Duronio, R.J. Mol. Cell. Biol. (2003) [Pubmed]
  10. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Royzman, I., Austin, R.J., Bosco, G., Bell, S.P., Orr-Weaver, T.L. Genes Dev. (1999) [Pubmed]
  11. Targeted expression of the DNA binding domain of DRE-binding factor, a Drosophila transcription factor, attenuates DNA replication of the salivary gland and eye imaginal disc. Hirose, F., Yamaguchi, M., Matsukage, A. Mol. Cell. Biol. (1999) [Pubmed]
  12. Distinct roles of E2F recognition sites as positive or negative elements in regulation of the DNA polymerase alpha 180 kDa catalytic subunit gene promoter during Drosophila development. Yamaguchi, M., Hayashi, Y., Hirose, F., Nishimoto, Y., Matsukage, A. Nucleic Acids Res. (1997) [Pubmed]
  13. Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells. Parakati, R., Dimario, J.X. Dev. Dyn. (2005) [Pubmed]
  14. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Follette, P.J., Duronio, R.J., O'Farrell, P.H. Curr. Biol. (1998) [Pubmed]
  15. Hypoxia induces major effects on cell cycle kinetics and protein expression in Drosophila melanogaster embryos. Douglas, R.M., Farahani, R., Morcillo, P., Kanaan, A., Xu, T., Haddad, G.G. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  16. The caudal homeodomain protein activates Drosophila E2F gene expression. Hwang, M.S., Kim, Y.S., Choi, N.H., Park, J.H., Oh, E.J., Kwon, E.J., Yamaguchi, M., Yoo, M.A. Nucleic Acids Res. (2002) [Pubmed]
  17. Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. Hao, X.F., Alphey, L., Bandara, L.R., Lam, E.W., Glover, D., La Thangue, N.B. J. Cell. Sci. (1995) [Pubmed]
  18. Kinase-independent activity of Cdc2/cyclin A prevents the S phase in the Drosophila cell cycle. Hayashi, S., Yamaguchi, M. Genes Cells (1999) [Pubmed]
  19. S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Leng, X., Connell-Crowley, L., Goodrich, D., Harper, J.W. Curr. Biol. (1997) [Pubmed]
  20. The DNA replication-related element (DRE)/DRE-binding factor system is a transcriptional regulator of the Drosophila E2F gene. Sawado, T., Hirose, F., Takahashi, Y., Sasaki, T., Shinomiya, T., Sakaguchi, K., Matsukage, A., Yamaguchi, M. J. Biol. Chem. (1998) [Pubmed]
  21. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. Stevaux, O., Dimova, D., Frolov, M.V., Taylor-Harding, B., Morris, E., Dyson, N. EMBO J. (2002) [Pubmed]
  22. Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. Legent, K., Dutriaux, A., Delanoue, R., Silber, J. Genes Cells (2006) [Pubmed]
 
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