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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 41 documents. Results 1 - 10.

Homo sapiens
Gene: ... that this transcription factor is involved in human angiogenesis. Anatomical context of EPAS1 EPAS1 was detected in all...Disease relevance of EPAS1 Exposure of cultured A549 cells to hypoxia increased EPAS1 mRNA and protein levels. We showed that EPAS1, but not HIF- 1alpha, is abundantly expressed in human lung... / Synonyms: EPAS-1
Rattus norvegicus
Gene: ... Disease relevance of Epas1 EPAS1 trans- activation during hypoxia requires p42/ p44 MAPK. Here we... transduced with adenovirus expressing EPAS1. High impact information on Epas1 Interestingly, NGF effect... no effect on EPAS1 phosphorylation during hypoxia, suggesting that MAPK targets other proteins... / Synonyms: EPAS-1
Mus musculus
Gene: ... Disease relevance of Epas1 Cre- mediated removal of the inserted gene recovered normal HLF... sandwiched between two loxP sequences into exon 1 of the HLF gene. EPAS1- null as well as heterozygous mice... lacking wild- type HIF- 2alpha, encoded by the EPAS1 gene, exhibit pancytopenia. High impact information... / Synonyms: EPAS-1
Gallus gallus
Gene: ... High impact information on EPAS1 In contrast, sequence homology between the chick HIF- 1alpha and endothelial PAS protein 1( EPAS1 ), another member of the bHLH- PAS proteins, was only low( 49 %)....
Bos taurus
Gene: ... Disease relevance of EPAS1 Since VEGF plays a crucial role in angiogenesis, the ability of dominant- negative EPAS1 to inhibit VEGF promoter activity raises the possibility of a novel approach to inhibiting pathological angiogenesis. High impact information on EPAS1 In this report, we show that EPAS1 increased VEGF...
Danio rerio
Gene: Synonyms: epas1
MeSH term: ... of HIF- 1 alpha transactivation domains with coactivators is induced by hypoxia. We hypothesize that EPAS1 expressed in the OZ senses hypoxia during mid- gestational development and translates this signal..., is synthesized in the kidney and liver in response to hypoxia. These observations raise the possibility that EPAS...
MeSH term: ... system, EPAS1- deficient mice display pronounced bradycardia. Thioridazine( Mellaril) hydrochloride..., whereas sinus bradycardia was associated with LQT1. All HR effects were probably mediated by CRF( 1...
Macaca mulatta
Gene
Pan troglodytes
Gene

 

 
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