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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 41 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of MBD4 Of the MSI- H polyps, 2 had a somatic frameshift mutation of the MBD4 gene, 1 of MSH6, 1 of BAX, and 2 of transforming growth factor betaRII. CONCLUSIONS: Mutations in MBD4... in the same patient. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch... / Synonyms: Methyl-CpG-binding protein MBD4
Mus musculus
Gene: ... High impact information on Mbd4 Within the nucleus, FADD interacted with the methyl- CpG binding domain protein 4( MBD4 ), which excises thymine from GT mismatches in methylated regions of chromatin... link between genome surveillance and apoptosis. Although Mbd4 inactivation did not increase... / Synonyms: Methyl-CpG-binding protein MBD4
MeSH term: ... the gene for the methyl- CpG binding thymine glycosylase, MBD4, in over 40% of microsatellite unstable... inhibitors. Here we report that although all nonsense and frameshift mutations that cause premature... was found. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce...
MeSH term: ... during hepatocarcinogenesis, and that reduced expression of MBD4 may play a role in malignant progression... differential methylation. Because not all PIA cells are positive for GSTP1 protein, we hypothesized that some... sequencing method indicate that the BRCA1 CpG island is regionally methylated in all human tissues analyzed...
Chemical compound: ... in favor of thymine( 8 %). The thymine glycosylase MBD4 can bind to the product of deamination...G- binding protein MBD4. Analytical, diagnostic and therapeutic context of thymine In an attempt to find...) that displays unlimited growth potential when all of the thymine residues in nuclear DNA are replaced... / Synonyms: PubChem9313
Chemical compound: ... , and a structure revision of isatan B. Gene context of thymine We tested this hypothesis by analyzing Mbd4 -/- mice.... The mammalian protein MBD4 contains a methyl- CpG binding domain and can enzymatically remove thymine( T...
Mus musculus
Gene: ... . High impact information on Defb4 The base excision repair( BER) enzyme MED1( also known as MBD4) interacts with the MMR protein MLH1. The MBD4 active site is situated in a cleft that likely orients and binds DNA. MBD- 4 mRNA was expressed in the esophagus, tongue, and trachea but not in any of 20 other... / Synonyms: MBD-4
MeSH term: ... , as analyzed by an in vitro switch assay and by in vivo immunizations, is unaffected in Mbd4 (-/-) mice... antibody, all use members of the same gene families; remarkably, they also express identical amino acid.... All patients received the same dose and schedule of vaccine immunizations; those randomized...


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