Gene Review:
Mbd4 - methyl-CpG binding domain protein 4
Mus musculus
Synonyms:
Med1, Methyl-CpG-binding domain protein 4, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase
- Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Screaton, R.A., Kiessling, S., Sansom, O.J., Millar, C.B., Maddison, K., Bird, A., Clarke, A.R., Frisch, S.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Wong, E., Yang, K., Kuraguchi, M., Werling, U., Avdievich, E., Fan, K., Fazzari, M., Jin, B., Brown, A.M., Lipkin, M., Edelmann, W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Sansom, O.J., Bishop, S.M., Bird, A., Clarke, A.R. Oncogene (2004)
- Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. Bardwell, P.D., Martin, A., Wong, E., Li, Z., Edelmann, W., Scharff, M.D. J. Immunol. (2003)
- Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Millar, C.B., Guy, J., Sansom, O.J., Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P.D., Bishop, S.M., Clarke, A.R., Bird, A. Science (2002)
- MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Sansom, O.J., Zabkiewicz, J., Bishop, S.M., Guy, J., Bird, A., Clarke, A.R. Oncogene (2003)
- Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. Wu, P., Qiu, C., Sohail, A., Zhang, X., Bhagwat, A.S., Cheng, X. J. Biol. Chem. (2003)