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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 147 documents. Results 1 - 10.

Homo sapiens
Gene: ... gene. Biological context of MEN1 All tumours with MEN1 gene mutation showed LOH on 11q13, making...Disease relevance of MEN1 MEN1( Menin) gene- disease database Some cases are caused by inherited syndromes, such as multiple endocrine neoplasia type 1( MEN1; ref. 2 ). In most cases, the molecular basis...
Mus musculus
Gene: ... Disease relevance of Men1 Gene expression profiling in insulinomas of Men1{ beta }- cell mutant... loss of both copies of Men1, implies that additional somatic events are required for adenoma formation in beta cells. Conditional homozygous inactivation of the Men1 gene in the pituitary gland and endocrine...
MeSH term: ... identity( 50 %) with the extended- spectrum class A beta- lactamase MEN- 1 from E. coli. A patient had... neoplasia- type 1( MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors... hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild- type alleles in the parathyroid... / Synonyms: MEN 1; MEN1
Rattus norvegicus
Gene: ... Disease relevance of Men1 We here characterize the MEN1 gene homologs of the mouse and rat. cDNA was isolated from a mouse phage library, and two alternative MEN1 mRNA transcripts containing variant 5... information on Men1 Germ- line missense mutations of the receptor- like tyrosine kinase ret are the causative...
Caenorhabditis elegans
MeSH term: ... on chromosome 11, which may also involve the MEN- 1 gene. We have recently shown that 70% of human...) for polymorphic markers on 11q13, the site of the MEN1 tumour suppressor gene. Here, we show that loss... tumours with MEN1 gene mutation showed LOH on 11q13, making the tumour cells hemi- or homozygous...
Caenorhabditis remanei
Homo sapiens
Gene: ... in the human CDKN1B gene in a MEN1 mutation- negative patient presenting with pituitary and parathyroid tumors... to regulatory polymorphisms could indeed influence the risk of childhood pre- B ALL and contribute... / Synonyms: MEN1B
MeSH term: ... sporadic adenomas from patients without MEN- 1, 9 showed similar allelic losses in chromosome 11; in 7 the losses included the apparent MEN- 1 locus. A reduction in the DNA methyltransferase activity in Min mice... was observed in three cases, and CRH receptor signal was undetected in all. METHODS: The expression...
MeSH term: ... cascade. Multiple endocrine neoplasia type 1( MEN- 1) is a predisposition to hyperplasia...


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