The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDKN1B  -  cyclin-dependent kinase inhibitor 1B (p27,...

Homo sapiens

Synonyms: CDKN4, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, KIP1, MEN1B, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CDKN1B


High impact information on CDKN1B


Chemical compound and disease context of CDKN1B


Biological context of CDKN1B


Anatomical context of CDKN1B


Associations of CDKN1B with chemical compounds


Physical interactions of CDKN1B


Regulatory relationships of CDKN1B


Other interactions of CDKN1B

  • In apoptotic cells, the C termini of the cdk inhibitors p21Cip1/Waf1 and p27Kip1 are truncated by specific cleavage [19].
  • Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis [33].
  • In addition, the putative loss of wild-type function of CDKN1B and ETV6 could indicate a synergistic effect of both genes in the pathogenesis of this leukemia case [2].
  • These data suggest that pRb2/p130 and p27Kip1 may cooperate in regulating cellular proliferation, and both may be involved in a negative feedback regulatory loop with cyclin E [24].
  • p27Kip1 is required for PTEN-induced G1 growth arrest [27].

Analytical, diagnostic and therapeutic context of CDKN1B


  1. A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer. Chang, B.L., Zheng, S.L., Isaacs, S.D., Wiley, K.E., Turner, A., Li, G., Walsh, P.C., Meyers, D.A., Isaacs, W.B., Xu, J. Cancer Res. (2004) [Pubmed]
  2. Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case. Wlodarska, I., Baens, M., Peeters, P., Aerssens, J., Mecucci, C., Brock, P., Marynen, P., Van den Berghe, H. Cancer Res. (1996) [Pubmed]
  3. Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma. Gebauer, S., Yu, A.L., Omura-Minamisawa, M., Batova, A., Diccianni, M.B. Genes Chromosomes Cancer (2004) [Pubmed]
  4. Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Andreasson, P., Johansson, B., Arheden, K., Billström, R., Mitelman, F., Höglund, M. Genes Chromosomes Cancer (1997) [Pubmed]
  5. Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements. Andreasson, P., Johansson, B., Billström, R., Garwicz, S., Mitelman, F., Höglund, M. Leukemia (1998) [Pubmed]
  6. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Koyama, H., Raines, E.W., Bornfeldt, K.E., Roberts, J.M., Ross, R. Cell (1996) [Pubmed]
  7. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Kawasaki, H., Eckner, R., Yao, T.P., Taira, K., Chiu, R., Livingston, D.M., Yokoyama, K.K. Nature (1998) [Pubmed]
  8. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nagahara, H., Vocero-Akbani, A.M., Snyder, E.L., Ho, A., Latham, D.G., Lissy, N.A., Becker-Hapak, M., Ezhevsky, S.A., Dowdy, S.F. Nat. Med. (1998) [Pubmed]
  9. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Porter, P.L., Malone, K.E., Heagerty, P.J., Alexander, G.M., Gatti, L.A., Firpo, E.J., Daling, J.R., Roberts, J.M. Nat. Med. (1997) [Pubmed]
  10. Involvement of cyclin-dependent kinase inhibitor p27Kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesterone. Shiozawa, T., Nikaido, T., Nakayama, K., Lu, X., Fujii, S. Mol. Hum. Reprod. (1998) [Pubmed]
  11. Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. Kardinal, C., Dangers, M., Kardinal, A., Koch, A., Brandt, D.T., Tamura, T., Welte, K. Blood (2006) [Pubmed]
  12. Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries. Jin, L., Qian, X., Kulig, E., Sanno, N., Scheithauer, B.W., Kovacs, K., Young, W.F., Lloyd, R.V. Am. J. Pathol. (1997) [Pubmed]
  13. Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells. Tsihlias, J., Zhang, W., Bhattacharya, N., Flanagan, M., Klotz, L., Slingerland, J. Oncogene (2000) [Pubmed]
  14. The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Xia, Z.B., Popovic, R., Chen, J., Theisler, C., Stuart, T., Santillan, D.A., Erfurth, F., Diaz, M.O., Zeleznik-Le, N.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Healy, J., B??langer, H., Beaulieu, P., Larivi??re, M., Labuda, D., Sinnett, D. Blood (2007) [Pubmed]
  16. CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma. Kibel, A.S., Suarez, B.K., Belani, J., Oh, J., Webster, R., Brophy-Ebbers, M., Guo, C., Catalona, W.J., Picus, J., Goodfellow, P.J. Cancer Res. (2003) [Pubmed]
  17. A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p). Baens, M., Wlodarska, I., Corveleyn, A., Hoornaert, I., Hagemeijer, A., Marynen, P. Genomics (1999) [Pubmed]
  18. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Pellegata, N.S., Quintanilla-Martinez, L., Siggelkow, H., Samson, E., Bink, K., H??fler, H., Fend, F., Graw, J., Atkinson, M.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  19. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Levkau, B., Koyama, H., Raines, E.W., Clurman, B.E., Herren, B., Orth, K., Roberts, J.M., Ross, R. Mol. Cell (1998) [Pubmed]
  20. Cyclin-dependent kinase 6 is the principal target of p27/Kip1 regulation of the G1-phase traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells. Wang, Q.M., Luo, X., Studzinski, G.P. Cancer Res. (1997) [Pubmed]
  21. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Pietenpol, J.A., Bohlander, S.K., Sato, Y., Papadopoulos, N., Liu, B., Friedman, C., Trask, B.J., Roberts, J.M., Kinzler, K.W., Rowley, J.D. Cancer Res. (1995) [Pubmed]
  22. Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. Foster, J.S., Fernando, R.I., Ishida, N., Nakayama, K.I., Wimalasena, J. J. Biol. Chem. (2003) [Pubmed]
  23. Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins. Zancai, P., Dal Col, J., Piccinin, S., Guidoboni, M., Cariati, R., Rizzo, S., Boiocchi, M., Maestro, R., Dolcetti, R. Oncogene (2005) [Pubmed]
  24. Inducible pRb2/p130 expression and growth-suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop. Howard, C.M., Claudio, P.P., De Luca, A., Stiegler, P., Jori, F.P., Safdar, N.M., Caputi, M., Khalili, K., Giordano, A. Cancer Res. (2000) [Pubmed]
  25. High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma. Kamata, Y., Watanabe, J., Nishimura, Y., Arai, T., Kawaguchi, M., Hattori, M., Obokata, A., Kuramoto, H. J. Cancer Res. Clin. Oncol. (2005) [Pubmed]
  26. Vitamin D3 receptor/Sp1 complex is required for the induction of p27Kip1 expression by vitamin D3. Huang, Y.C., Chen, J.Y., Hung, W.C. Oncogene (2004) [Pubmed]
  27. p27Kip1 is required for PTEN-induced G1 growth arrest. Gottschalk, A.R., Basila, D., Wong, M., Dean, N.M., Brandts, C.H., Stokoe, D., Haas-Kogan, D.A. Cancer Res. (2001) [Pubmed]
  28. Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Yang, G., Ayala, G., De Marzo, A., Tian, W., Frolov, A., Wheeler, T.M., Thompson, T.C., Harper, J.W. Clin. Cancer Res. (2002) [Pubmed]
  29. Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. Doki, Y., Imoto, M., Han, E.K., Sgambato, A., Weinstein, I.B. Carcinogenesis (1997) [Pubmed]
  30. HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Le, X.F., Pruefer, F., Bast, R.C. Cell Cycle (2005) [Pubmed]
  31. Growth regulation by p27Kip1 is abrogated by multiple mechanisms in aggressive malignant lymphomas. Lin, Z., Lim, S., Lim, M.S. Br. J. Haematol. (2003) [Pubmed]
  32. p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells. Wang, Q., Zhou, Y., Wang, X., Evers, B.M. Cell Death Differ. (2008) [Pubmed]
  33. Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis. Quintanilla-Martinez, L., Davies-Hill, T., Fend, F., Calzada-Wack, J., Sorbara, L., Campo, E., Jaffe, E.S., Raffeld, M. Blood (2003) [Pubmed]
  34. Characterization of a t(10;12)(q24;p13) in a case of CML in transformation. Aguiar, R.C., Chase, A., Oscier, D.G., Carapeti, M., Goldman, J.M., Cross, N.C. Genes Chromosomes Cancer (1997) [Pubmed]
  35. Deletion mapping at 12p12-13 in metastatic prostate cancer. Kibel, A.S., Freije, D., Isaacs, W.B., Bova, G.S. Genes Chromosomes Cancer (1999) [Pubmed]
  36. Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia. Min, Y.H., Cheong, J.W., Kim, J.Y., Eom, J.I., Lee, S.T., Hahn, J.S., Ko, Y.W., Lee, M.H. Cancer Res. (2004) [Pubmed]
WikiGenes - Universities