Gene Review:
Men1 - multiple endocrine neoplasia 1
Mus musculus
Synonyms:
AW045611, Menin, menin
Forsberg,
Zablewska,
Piehl,
Weber,
Lagercrantz,
Gaudray,
Höög,
Larsson,
Libutti,
Crabtree,
Lorang,
Burns,
Mazzanti,
Hewitt,
O'Connor,
Ward,
Emmert-Buck,
Remaley,
Miller,
Turner,
Alexander,
Arnold,
Marx,
Collins,
Spiegel,
Agarwal,
Novotny,
Crabtree,
Weitzman,
Yaniv,
Burns,
Chandrasekharappa,
Collins,
Spiegel,
Marx,
- Gene expression profiling in insulinomas of Men1 {beta}-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic {beta}-cell tumorigenesis. Fontani??re, S., Tost, J., Wierinckx, A., Lachuer, J., Lu, J., Hussein, N., Busato, F., Gut, I., Wang, Z.Q., Zhang, C.X. Endocr. Relat. Cancer (2006)
- Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2. La, P., Schnepp, R.W., D Petersen, C., C Silva, A., Hua, X. Endocrinology (2004)
- Of mice and MEN1: Insulinomas in a conditional mouse knockout. Crabtree, J.S., Scacheri, P.C., Ward, J.M., McNally, S.R., Swain, G.P., Montagna, C., Hager, J.H., Hanahan, D., Edlund, H., Magnuson, M.A., Garrett-Beal, L., Burns, A.L., Ried, T., Chandrasekharappa, S.C., Marx, S.J., Spiegel, A.M., Collins, F.S. Mol. Cell. Biol. (2003)
- Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Biondi, C.A., Gartside, M.G., Waring, P., Loffler, K.A., Stark, M.S., Magnuson, M.A., Kay, G.F., Hayward, N.K. Mol. Cell. Biol. (2004)
- Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Libutti, S.K., Crabtree, J.S., Lorang, D., Burns, A.L., Mazzanti, C., Hewitt, S.M., O'Connor, S., Ward, J.M., Emmert-Buck, M.R., Remaley, A., Miller, M., Turner, E., Alexander, H.R., Arnold, A., Marx, S.J., Collins, F.S., Spiegel, A.M. Cancer Res. (2003)
- Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Romeo, G., Ronchetto, P., Luo, Y., Barone, V., Seri, M., Ceccherini, I., Pasini, B., Bocciardi, R., Lerone, M., Kääriäinen, H. Nature (1994)
- Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Hughes, C.M., Rozenblatt-Rosen, O., Milne, T.A., Copeland, T.D., Levine, S.S., Lee, J.C., Hayes, D.N., Shanmugam, K.S., Bhattacharjee, A., Biondi, C.A., Kay, G.F., Hayward, N.K., Hess, J.L., Meyerson, M. Mol. Cell (2004)
- C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. Smith-Hicks, C.L., Sizer, K.C., Powers, J.F., Tischler, A.S., Costantini, F. EMBO J. (2000)
- The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Chen, Y.X., Yan, J., Keeshan, K., Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S., Hua, X. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype. Ito, S., Iwashita, T., Asai, N., Murakami, H., Iwata, Y., Sobue, G., Takahashi, M. Cancer Res. (1997)
- Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src. Nakaigawa, N., Weirich, G., Schmidt, L., Zbar, B. Oncogene (2000)
- p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors. Bai, F., Pei, X.H., Nishikawa, T., Smith, M.D., Xiong, Y. Mol. Cell. Biol. (2007)
- Menin induces apoptosis in murine embryonic fibroblasts. Schnepp, R.W., Mao, H., Sykes, S.M., Zong, W.X., Silva, A., La, P., Hua, X. J. Biol. Chem. (2004)
- Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Bertolino, P., Radovanovic, I., Casse, H., Aguzzi, A., Wang, Z.Q., Zhang, C.X. Mech. Dev. (2003)
- Menin interacts directly with the homeobox-containing protein Pem. Lemmens, I.H., Forsberg, L., Pannett, A.A., Meyen, E., Piehl, F., Turner, J.J., Van de Ven, W.J., Thakker, R.V., Larsson, C., Kas, K. Biochem. Biophys. Res. Commun. (2001)
- Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Bertolino, P., Tong, W.M., Herrera, P.L., Casse, H., Zhang, C.X., Wang, Z.Q. Cancer Res. (2003)
- Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage. Sowa, H., Kaji, H., Canaff, L., Hendy, G.N., Tsukamoto, T., Yamaguchi, T., Miyazono, K., Sugimoto, T., Chihara, K. J. Biol. Chem. (2003)
- Multiple Endocrine Neoplasia Type 1 Interacts with Forkhead Transcription Factor CHES1 in DNA Damage Response. Busygina, V., Kottemann, M.C., Scott, K.L., Plon, S.E., Bale, A.E. Cancer Res. (2006)
- Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Kato, M., Takeda, K., Kawamoto, Y., Iwashita, T., Akhand, A.A., Senga, T., Yamamoto, M., Sobue, G., Hamaguchi, M., Takahashi, M., Nakashima, I. Cancer Res. (2002)
- Expression of CD109 in human cancer. Hashimoto, M., Ichihara, M., Watanabe, T., Kawai, K., Koshikawa, K., Yuasa, N., Takahashi, T., Yatabe, Y., Murakumo, Y., Zhang, J.M., Nimura, Y., Takahashi, M. Oncogene (2004)
- Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Karnik, S.K., Hughes, C.M., Gu, X., Rozenblatt-Rosen, O., McLean, G.W., Xiong, Y., Meyerson, M., Kim, S.K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor. Pandit, S.D., Donis-Keller, H., Iwamoto, T., Tomich, J.M., Pike, L.J. J. Biol. Chem. (1996)
- Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation. Hayashi, Y., Iwashita, T., Murakamai, H., Kato, Y., Kawai, K., Kurokawa, K., Tohnai, I., Ueda, M., Takahashi, M. Biochem. Biophys. Res. Commun. (2001)
- Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Agarwal, S.K., Novotny, E.A., Crabtree, J.S., Weitzman, J.B., Yaniv, M., Burns, A.L., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Marx, S.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation. Kawai, K., Iwashita, T., Murakami, H., Hiraiwa, N., Yoshiki, A., Kusakabe, M., Ono, K., Iida, K., Nakayama, A., Takahashi, M. Cancer Res. (2000)
- Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease. Carlomagno, F., Melillo, R.M., Visconti, R., Salvatore, G., De Vita, G., Lupoli, G., Yu, Y., Jing, S., Vecchio, G., Fusco, A., Santoro, M. Endocrinology (1998)
- Characterization of the mouse Men1 gene and its expression during development. Stewart, C., Parente, F., Piehl, F., Farnebo, F., Quincey, D., Silins, G., Bergman, L., Carle, G.F., Lemmens, I., Grimmond, S., Xian, C.Z., Khodei, S., Teh, B.T., Lagercrantz, J., Siggers, P., Calender, A., Van de Vem, V., Kas, K., Weber, G., Hayward, N., Gaudray, P., Larsson, C. Oncogene (1998)
- Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse. Forsberg, L., Zablewska, B., Piehl, F., Weber, G., Lagercrantz, S., Gaudray, P., Höög, C., Larsson, C. Int. J. Mol. Med. (2001)
- Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Bertolino, P., Tong, W.M., Galendo, D., Wang, Z.Q., Zhang, C.X. Mol. Endocrinol. (2003)
- Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse. Zablewska, B., Bylund, L., Mandic, S.A., Fromaget, M., Gaudray, P., Weber, G. J. Clin. Endocrinol. Metab. (2003)