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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 156 documents. Results 1 - 10.

Homo sapiens
Gene: ... to tumor formation in all animals at 4- 7 months of age. A novel SMAD4 gene mutation in seminoma germ cell...Disease relevance of SMAD4 SMAD4 gene- disease database. SMAD4 is inactivated in the majority... suppressor locus and activation of the KRAS oncogene. SMAD4 mutations can therefore account for about 50- 60... / Synonyms: SMAD 4; Smad4; hSMAD4
Mus musculus
Gene: ... Disease relevance of Smad4 Taking advantage of this fact, we constructed previously a cis- compound Apc( delta716) Smad4 mutant, the intestinal polyps of which progress to very invasive adenocarcinomas. In both simple Apc( Delta716) and compound Apc( Delta716) Smad4 mutants, MVD increased in a polyp size... / Synonyms: SMAD 4; Smad 4
Rattus norvegicus
Gene: ... inhibitor leptomycin B. Smad4 was broadly expressed in all zones of epiphyseal plate. Inhibition of Smads...Disease relevance of Smad4 Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/ 2. 8 cells and primary rat calvaria cells. In Smad4... / Synonyms: SMAD 4
Canis lupus familiaris
Gene: ... High impact information on SMAD4 However, we found no evidence in this system that ERK can significantly influence the function of Smad2, Smad3, and Smad4 at the level of nuclear translocation, DNA binding, or transcriptional activation....
Sus scrofa
Gene: ... High impact information on SMAD4 Both TGF- beta1 and activin A, but not BMP- 7, increased the phosphorylation of Smad2, induced nuclear translocation of Smad2, Smad3, and Smad4, and inhibited thyrocyte cell... Thr276 of Smad4 and that phosphorylation can lead to enhanced TGF- beta- induced nuclear accumulation...
Ciona intestinalis
Xenopus laevis
Gene: Synonyms: smad4; smad4a; smad4alpha
MeSH term: ... in approximately 50% of esophageal, stomach, and colon carcinomas. The Smad4/ DPC4 tumour suppressor is inactivated...- induced skin tumors, but 70% of carcinomas from Pten +/- mice do not exhibit this mutation, and in all... of chemotherapeutic treatment for all tumors; for ovarian and small- cell lung carcinomas( SCLCs ), these levels were...
Xenopus (Silurana) tropicalis
Gene: Synonyms: smad4; smad4a; smad4alpha
Xenopus (Silurana) tropicalis
Gene: Synonyms: Smad4b; Smad4beta


Links to contributing authors: Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
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