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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 156 documents. Results 1 - 10.

Homo sapiens
Gene: ... to tumor formation in all animals at 4- 7 months of age. A novel SMAD4 gene mutation in seminoma germ cell...Disease relevance of SMAD4 SMAD4 gene- disease database. SMAD4 is inactivated in the majority... suppressor locus and activation of the KRAS oncogene. SMAD4 mutations can therefore account for about 50- 60... / Synonyms: SMAD 4; Smad4; hSMAD4
Mus musculus
Gene: ... Disease relevance of Smad4 Taking advantage of this fact, we constructed previously a cis- compound Apc( delta716) Smad4 mutant, the intestinal polyps of which progress to very invasive adenocarcinomas. In both simple Apc( Delta716) and compound Apc( Delta716) Smad4 mutants, MVD increased in a polyp size... / Synonyms: SMAD 4; Smad 4
Rattus norvegicus
Gene: ... inhibitor leptomycin B. Smad4 was broadly expressed in all zones of epiphyseal plate. Inhibition of Smads...Disease relevance of Smad4 Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/ 2. 8 cells and primary rat calvaria cells. In Smad4... / Synonyms: SMAD 4
Canis lupus familiaris
Gene: ... High impact information on SMAD4 However, we found no evidence in this system that ERK can significantly influence the function of Smad2, Smad3, and Smad4 at the level of nuclear translocation, DNA binding, or transcriptional activation....
Sus scrofa
Gene: ... High impact information on SMAD4 Both TGF- beta1 and activin A, but not BMP- 7, increased the phosphorylation of Smad2, induced nuclear translocation of Smad2, Smad3, and Smad4, and inhibited thyrocyte cell... Thr276 of Smad4 and that phosphorylation can lead to enhanced TGF- beta- induced nuclear accumulation...
Ciona intestinalis
Gene
Xenopus laevis
Gene: Synonyms: smad4; smad4a; smad4alpha
MeSH term: ... in approximately 50% of esophageal, stomach, and colon carcinomas. The Smad4/ DPC4 tumour suppressor is inactivated...- induced skin tumors, but 70% of carcinomas from Pten +/- mice do not exhibit this mutation, and in all... of chemotherapeutic treatment for all tumors; for ovarian and small- cell lung carcinomas( SCLCs ), these levels were...
Xenopus (Silurana) tropicalis
Gene: Synonyms: smad4; smad4a; smad4alpha
Xenopus (Silurana) tropicalis
Gene: Synonyms: Smad4b; Smad4beta

 

 
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