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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 207 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of TOP1 The t( 11; 20 )( p15; q11) chromosomal translocation associated with therapy- related myelodysplastic syndrome results in an NUP98- TOP1 fusion. Moreover, in a murine bone marrow transplantation model, NUP98- TOP1 expression led to a lethal, transplantable leukemia...
Homo sapiens
Gene: ... High impact information on TOP1MT The TOP1mt gene is highly homologous to the nuclear TOP1 gene and consists of 14 exons.... / Synonyms: TOP1mt
Arabidopsis thaliana
Gene: ... High impact information on TOP1alpha The top1 nucleotide sequence encoded an open reading frame of 2370 bp, predicting a protein of 90 kDa. Evaluation of the top1 mRNA steady- state level revealed... proliferation. Despite the physiological importance, the regulation of top1 gene expression has not yet been... / Synonyms: TOP1; TOP1ALPHA
Mus musculus
Gene: ... Disease relevance of Top1 OBJECTIVE: Autoantibodies to DNA topoisomerase I( topo I) are associated...- sensitive cells( Deffie et al ., Cancer Res ., 49: 58- 62, 1989). High impact information on Top1 DNA... embryos lacking DNA topoisomerase IIbeta. Chemical compound and disease context of Top1 Decreased DNA... / Synonyms: Top-1
Arabidopsis thaliana
Gene: ... High impact information on TOP1BETA Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis. RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy- dependent cell growth. DNA gyrase is the bacterial DNA topoisomerase( topo) that supercoils DNA... / Synonyms: TOP1; TOP1BETA
Drosophila melanogaster
Gene: ... Disease relevance of Top1 Using a single- molecule micromanipulation setup, we follow the real... information on Top1 The in vivo distribution of topoisomerase I on specific DNA sequences is determined.... Biological context of Top1 This enzyme partially relaxes a hypernegatively supercoiled plasmid substrate... / Synonyms: TOP1; l(1)top1; top1
Schizosaccharomyces pombe 972h-
Gene: ... High impact information on top1 In contrast, the double top1 top2 mutants were rapidly arrested at various stages of the cell cycle, showing a strikingly altered nuclear chromatin region....
Saccharomyces cerevisiae S288c
Gene: ... interactions of TOP1 None of these genes is required for viability and all SLX null mutations are synthetically...Disease relevance of TOP1 Rabbit antibodies specific to yeast DNA topoisomerase I were used... have investigated the role of TOP1 in hydrogen peroxide toxicity. We have shown that overexpression...
Homo sapiens
Gene: ... High impact information on TOP1P2 A TaqI RFLP at the human TOP1 pseudogene locus on chromosome 22q11. 2- 13. 1( TOP1P2). The Top- 1ps locus, together with the immunoglobulin- lambda- light- chain... of the human pseudogene TOP1P2. Increased loss of heterozygosity during tumor progression or recurrence...
Rattus norvegicus
Gene: ... Disease relevance of Top1 Newly replicated DNA is associated with DNA topoisomerase II in cultured.... High impact information on Top1 Our results suggest that DNA topoisomerase II may interact with newly.... Biological context of Top1 We have now examined whether the enzyme, DNA topoisomerase II, which has been...


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