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Top1  -  topoisomerase (DNA) I

Rattus norvegicus

Synonyms: DNA topoisomerase 1, DNA topoisomerase I
 
 
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Disease relevance of Top1

 

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Biological context of Top1

 

Anatomical context of Top1

 

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Analytical, diagnostic and therapeutic context of Top1

References

  1. Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells. Nelson, W.G., Liu, L.F., Coffey, D.S. Nature (1986) [Pubmed]
  2. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. Morris, E.J., Geller, H.M. J. Cell Biol. (1996) [Pubmed]
  3. Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription. Rose, K.M., Szopa, J., Han, F.S., Cheng, Y.C., Richter, A., Scheer, U. Chromosoma (1988) [Pubmed]
  4. St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats. Hu, Z., Yang, X., Ho, P.C., Chan, E., Chan, S.Y., Xu, C., Li, X., Zhu, Y.Z., Duan, W., Chen, X., Huang, M., Yang, H., Zhou, S. Pharm. Res. (2005) [Pubmed]
  5. Glucocorticoid-induced changes in liver: effect of dexamethasone administration on DNA topoisomerase I and II activities and distribution of histone H1 subtypes. Goodlad, G.A., Clark, C.M. Cell Biochem. Funct. (1994) [Pubmed]
  6. Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene. Garg, L.C., DiAngelo, S., Jacob, S.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. Nelson, W.G., Cho, K.R., Hsiang, Y.H., Liu, L.F., Coffey, D.S. Cancer Res. (1987) [Pubmed]
  8. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. Cohen, G.M., Sun, X.M., Fearnhead, H., MacFarlane, M., Brown, D.G., Snowden, R.T., Dinsdale, D. J. Immunol. (1994) [Pubmed]
  9. Evidence for a role of topoisomerase II in the Ca2+-dependent basal level expression of the rat prolactin gene. White, B.A., Preston, G.M. Mol. Endocrinol. (1988) [Pubmed]
  10. Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA. Been, M.D., Burgess, R.R., Champoux, J.J. Nucleic Acids Res. (1984) [Pubmed]
  11. Sp1 mediates cell proliferation-dependent regulation of rat DNA topoisomerase IIalpha gene promoter. Yoon, J.H., Kim, J.K., Rha, G.B., Oh, M., Park, S.H., Seong, R.H., Hong, S.H., Park, S.D. Biochem. J. (1999) [Pubmed]
  12. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. Xiao, Z., Bastow, K.F., Vance, J.R., Sidwell, R.S., Wang, H.K., Chen, M.S., Shi, Q., Lee, K.H. J. Med. Chem. (2004) [Pubmed]
  13. Antibody-array technique reveals overexpression of important DNA-repair proteins during cardiac ischemic preconditioning. Mathur, P., Kaga, S., Zhan, L., Das, D.K., Maulik, N. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  14. Mitochondria contain a distinct DNA topoisomerase. Fairfield, F.R., Bauer, W.R., Simpson, M.V. J. Biol. Chem. (1979) [Pubmed]
  15. Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II. McPherson, S.M., Longo, F.J. Dev. Biol. (1993) [Pubmed]
  16. A DNA topoisomerase I inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone. Barañao, J.L., Bley, M.A., Batista, F.D., Glikin, G.C. Biochem. J. (1991) [Pubmed]
  17. Stimulation of intracellular topoisomerase I activity by vasopressin and thrombin. Differential regulation by pertussis toxin. Nambi, P., Mattern, M., Bartus, J.O., Aiyar, N., Crooke, S.T. Biochem. J. (1989) [Pubmed]
  18. Developmental and hormonal regulation of type II DNA topoisomerase in rat testis. Bakshi, R.P., Galande, S., Bali, P., Dighe, R., Muniyappa, K. J. Mol. Endocrinol. (2001) [Pubmed]
  19. Identification of a transitional preapoptotic population of thymocytes. Cohen, G.M., Sun, X.M., Snowden, R.T., Ormerod, M.G., Dinsdale, D. J. Immunol. (1993) [Pubmed]
  20. Inhibition of RNA polymerase I-directed transcription by novobiocin. Potential use of novobiocin as a general inhibitor of eukaryotic transcription initiation. Webb, M.L., Jacob, S.T. J. Biol. Chem. (1988) [Pubmed]
  21. Soybean isoflavones, genistein and genistin, inhibit rat myoblast proliferation, fusion and myotube protein synthesis. Ji, S., Willis, G.M., Frank, G.R., Cornelius, S.G., Spurlock, M.E. J. Nutr. (1999) [Pubmed]
  22. Relationship between DNA topoisomerase I activity and DNA synthesis in cultured hepatocytes: effects of orotic acid. Giannoni, P., Fronza, G., Scarabelli, L., Fugassa, E., Orunesu, M., Cesarone, C.F. Boll. Soc. Ital. Biol. Sper. (1991) [Pubmed]
  23. Enzymes involved in DNA synthesis in the testes are regulated by temperature in vitro. Fujisawa, M., Hayashi, A., Okada, H., Arakawa, S., Kamidono, S. Eur. Urol. (1997) [Pubmed]
  24. Androgenic regulation of enzymes involved in DNA synthesis in epididymis of young rats. Imanishi, O., Fujisawa, M., Matsumoto, O., Kamidono, S. J. Reprod. Fertil. (1992) [Pubmed]
  25. Nuclear matrix in developing rat spermatogenic cells. Chen , J.L., Guo, S.H., Gao, F.H. Mol. Reprod. Dev. (2001) [Pubmed]
  26. DNA topoisomerase I activity in regenerating liver of hypothyroid rats. Merlo, M., Scarabelli, L., Bottazzi, C., Demori, I., Cesarone, C.F. Boll. Soc. Ital. Biol. Sper. (1998) [Pubmed]
 
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