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Gene Review

Top1  -  topoisomerase (DNA) I

Rattus norvegicus

Synonyms: DNA topoisomerase 1, DNA topoisomerase I
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Anatomical context of Top1


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Analytical, diagnostic and therapeutic context of Top1


  1. Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells. Nelson, W.G., Liu, L.F., Coffey, D.S. Nature (1986) [Pubmed]
  2. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. Morris, E.J., Geller, H.M. J. Cell Biol. (1996) [Pubmed]
  3. Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription. Rose, K.M., Szopa, J., Han, F.S., Cheng, Y.C., Richter, A., Scheer, U. Chromosoma (1988) [Pubmed]
  4. St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats. Hu, Z., Yang, X., Ho, P.C., Chan, E., Chan, S.Y., Xu, C., Li, X., Zhu, Y.Z., Duan, W., Chen, X., Huang, M., Yang, H., Zhou, S. Pharm. Res. (2005) [Pubmed]
  5. Glucocorticoid-induced changes in liver: effect of dexamethasone administration on DNA topoisomerase I and II activities and distribution of histone H1 subtypes. Goodlad, G.A., Clark, C.M. Cell Biochem. Funct. (1994) [Pubmed]
  6. Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene. Garg, L.C., DiAngelo, S., Jacob, S.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. Nelson, W.G., Cho, K.R., Hsiang, Y.H., Liu, L.F., Coffey, D.S. Cancer Res. (1987) [Pubmed]
  8. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. Cohen, G.M., Sun, X.M., Fearnhead, H., MacFarlane, M., Brown, D.G., Snowden, R.T., Dinsdale, D. J. Immunol. (1994) [Pubmed]
  9. Evidence for a role of topoisomerase II in the Ca2+-dependent basal level expression of the rat prolactin gene. White, B.A., Preston, G.M. Mol. Endocrinol. (1988) [Pubmed]
  10. Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA. Been, M.D., Burgess, R.R., Champoux, J.J. Nucleic Acids Res. (1984) [Pubmed]
  11. Sp1 mediates cell proliferation-dependent regulation of rat DNA topoisomerase IIalpha gene promoter. Yoon, J.H., Kim, J.K., Rha, G.B., Oh, M., Park, S.H., Seong, R.H., Hong, S.H., Park, S.D. Biochem. J. (1999) [Pubmed]
  12. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. Xiao, Z., Bastow, K.F., Vance, J.R., Sidwell, R.S., Wang, H.K., Chen, M.S., Shi, Q., Lee, K.H. J. Med. Chem. (2004) [Pubmed]
  13. Antibody-array technique reveals overexpression of important DNA-repair proteins during cardiac ischemic preconditioning. Mathur, P., Kaga, S., Zhan, L., Das, D.K., Maulik, N. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  14. Mitochondria contain a distinct DNA topoisomerase. Fairfield, F.R., Bauer, W.R., Simpson, M.V. J. Biol. Chem. (1979) [Pubmed]
  15. Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II. McPherson, S.M., Longo, F.J. Dev. Biol. (1993) [Pubmed]
  16. A DNA topoisomerase I inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone. Barañao, J.L., Bley, M.A., Batista, F.D., Glikin, G.C. Biochem. J. (1991) [Pubmed]
  17. Stimulation of intracellular topoisomerase I activity by vasopressin and thrombin. Differential regulation by pertussis toxin. Nambi, P., Mattern, M., Bartus, J.O., Aiyar, N., Crooke, S.T. Biochem. J. (1989) [Pubmed]
  18. Developmental and hormonal regulation of type II DNA topoisomerase in rat testis. Bakshi, R.P., Galande, S., Bali, P., Dighe, R., Muniyappa, K. J. Mol. Endocrinol. (2001) [Pubmed]
  19. Identification of a transitional preapoptotic population of thymocytes. Cohen, G.M., Sun, X.M., Snowden, R.T., Ormerod, M.G., Dinsdale, D. J. Immunol. (1993) [Pubmed]
  20. Inhibition of RNA polymerase I-directed transcription by novobiocin. Potential use of novobiocin as a general inhibitor of eukaryotic transcription initiation. Webb, M.L., Jacob, S.T. J. Biol. Chem. (1988) [Pubmed]
  21. Soybean isoflavones, genistein and genistin, inhibit rat myoblast proliferation, fusion and myotube protein synthesis. Ji, S., Willis, G.M., Frank, G.R., Cornelius, S.G., Spurlock, M.E. J. Nutr. (1999) [Pubmed]
  22. Relationship between DNA topoisomerase I activity and DNA synthesis in cultured hepatocytes: effects of orotic acid. Giannoni, P., Fronza, G., Scarabelli, L., Fugassa, E., Orunesu, M., Cesarone, C.F. Boll. Soc. Ital. Biol. Sper. (1991) [Pubmed]
  23. Enzymes involved in DNA synthesis in the testes are regulated by temperature in vitro. Fujisawa, M., Hayashi, A., Okada, H., Arakawa, S., Kamidono, S. Eur. Urol. (1997) [Pubmed]
  24. Androgenic regulation of enzymes involved in DNA synthesis in epididymis of young rats. Imanishi, O., Fujisawa, M., Matsumoto, O., Kamidono, S. J. Reprod. Fertil. (1992) [Pubmed]
  25. Nuclear matrix in developing rat spermatogenic cells. Chen , J.L., Guo, S.H., Gao, F.H. Mol. Reprod. Dev. (2001) [Pubmed]
  26. DNA topoisomerase I activity in regenerating liver of hypothyroid rats. Merlo, M., Scarabelli, L., Bottazzi, C., Demori, I., Cesarone, C.F. Boll. Soc. Ital. Biol. Sper. (1998) [Pubmed]
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