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Chemical Compound Review:

Coumarin 6 3-benzothiazol-2-yl-7- diethylamino-chromen...

Synonyms: CHEMBL212037, ACMC-209iyq, CHEBI:51942, ANW-28848, NSC-290432, ...

Eley, J.G. et al., Nicholas, A.P. et al., Lombry, C. et al.

Eley, Pujari, McLane, Nicholas, McInnis, Gupta, Snow, Love, Mason, Ferrell, Staas, Tice,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on NSC 290432

Coumarin-6 diffused within minutes across the trachea, airways and alveolar tissue but was also retained for hours in type II alveolar epithelial cells [1].
Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile and in vivo tissue distribution [2].
Dissolution over 168 hr was initially rapid followed by a steady decline, and tissue distribution showed coumarin-6 to be present in liver and lungs for a similar time period while in kidney, small intestines, and blood up to 96 hr [2].

Analytical, diagnostic and therapeutic context of NSC 290432

This was accomplished using microspheres containing the fluorescent dye coumarin-6 followed 1 day, 1 week and 1 month after intracerebral injections of this material were made into the rat brain [3].

References

Confocal imaging of rat lungs following intratracheal delivery of dry powders or solutions of fluorescent probes. Lombry, C., Bosquillon, C., Préat, V., Vanbever, R. Journal of controlled release : official journal of the Controlled Release Society. (2002) [Pubmed]
Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile and in vivo tissue distribution. Eley, J.G., Pujari, V.D., McLane, J. Drug delivery. (2004) [Pubmed]
The fate of biodegradable microspheres injected into rat brain. Nicholas, A.P., McInnis, C., Gupta, K.B., Snow, W.W., Love, D.F., Mason, D.W., Ferrell, T.M., Staas, J.K., Tice, T.R. Neurosci. Lett. (2002) [Pubmed]

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