Disease relevance of Nanostructures

• Compared with non-immunized mice or mice treated with 'naked' DNA, mice immunized with nanoparticles showed a substantial reduction in allergen-induced anaphylaxis associated with reduced levels of IgE, plasma histamine and vascular leakage [1].
• Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene [2].
• Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli [3].
• The vector consisted of single molecules of plasmid DNA carrying the cystic fibrosis transmembrane regulator- encoding gene compacted into DNA nanoparticles, using polyethylene glycol-substituted 30-mer lysine peptides [4].
• Since SiO(2) nanoparticles trigger a subnuclear pathology resembling the one occurring in expanded polyglutamine neurodegenerative disorders, we suggest that integrity of the functional architecture of the cell nucleus should be used as a read out for cytotoxicity and considered in the development of safe nanotechnology [5].

Psychiatry related information on Nanostructures

• Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease [6].
• TEM images of the hybrid film showed that the distribution of Au nanoparticles depends on the surface density of DODAC and reaction time [7].

High impact information on Nanostructures

• We expect that the use of transition-metal nanoparticles to enhance surface electrochemical reactivity will lead to further improvements in the performance of lithium-ion batteries [8].
• Mice receiving nanoparticles containing a dominant peanut allergen gene (pCMVArah2) produced secretory IgA and serum IgG2a [1].
• Ultralong beltlike (or ribbonlike) nanostructures (so-called nanobelts) were successfully synthesized for semiconducting oxides of zinc, tin, indium, cadmium, and gallium by simply evaporating the desired commercial metal oxide powders at high temperatures [9].
• These results, along with the observation that amyloid fibril formation by bacteria is highly orchestrated, suggest that fibril formation is an evolutionary conserved biological pathway used to generate natural product nanostructures [10].
• Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [11].

Chemical compound and disease context of Nanostructures

• Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles [12].
• We tested the effectiveness of ampicillin bound to nanoparticles of polyisohexylcyanoacrylate (PIHCA) in treating C57BL/6 mice experimentally infected with Salmonella typhimurium C5 [13].
• Tamoxifen-loaded nanoparticles may represent a new option for the treatment of experimental uveitis [14].
• Sensitive assay for identification of methicillin-resistant Staphylococcus aureus, based on direct detection of genomic DNA by use of gold nanoparticle probes [15].
• Chitosan easily forms microparticles and nanoparticles which encapsulate large amounts of antigens such as ovalbumin, diphtheria toxoid or tetanus toxoid [16].

Biological context of Nanostructures

• Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice [17].
• The stereochemistry of the carbohydrate hydroxyl groups and the number of amine units have been systematically changed in an effort to examine how the polymer chemistry affects the plasmid DNA (pDNA) binding affinity, the compaction of pDNA into nanoparticles (polyplexes), the material cytotoxicity, and the efficacy of nucleic acid delivery [18].
• Effect of pd nanoparticle size on the catalytic hydrogenation of allyl alcohol [19].
• Amphiphilic mixed PAA/PS brush-coated nanoparticles were synthesized from mixed PtBA/PS particles by hydrolysis of PtBA with iodotrimethylsilane [20].
• Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions [21].

Anatomical context of Nanostructures

• T cells were labeled for detection by magnetic resonance imaging using Food and Drug Administration-approved, superparamagnetic iron oxide nanoparticles (Ferumoxides) complexed to poly-L-Lysine (FE-PLL) [22].
• At a concentration of 100 nM, saquinavir was completely inactive in chronically HIV-infected macrophages, but when bound to nanoparticles it caused a 35% decrease in antigen production [23].
• Self-organized lipid-porphyrin bilayer membranes in vesicular form: nanostructure, photophysical properties, and dioxygen coordination [24].
• We have recently shown that doxorubicin bound to polysorbate-coated nanoparticles crossed the intact blood-brain barrier, thus reaching therapeutic concentrations in the brain [12].
• Dendrimer nanoparticles targeted by folic acid and having 6-TAMRA as a fluorescent probe were also used to label KB cell tumors in vivo [25].

Associations of Nanostructures with chemical compounds

• Study of Nd3+, Pd2+, Pt4+, and Fe3+ dopant effect on photoreactivity of TiO2 nanoparticles [26].
• Local administration of nanoparticles with incorporated dexamethasone significantly decreased neointimal formation [27].
• Fluorescence superquenching is investigated for polyelectrolytes consisting of cyanine dye pendant polylysines ranging in number of polymer repeat units (N(PRU)) from 1 to 900, both in solution and after adsorption onto silica nanoparticles [28].
• Alternatively, shell-crosslinked rod-shaped nanostructures with preserved morphology were obtained by the addition of the crosslinking agent before the addition of the carbodiimide, which allowed for the shell crosslinking to be performed at a faster rate than the morphological reorganization [29].
• Ultrafine particles (smaller than about 0.1 microm) are often emitted from combustion and other high-temperature processes in the form of fractal-like aggregates composed of solid nanoparticles [30].

Gene context of Nanostructures

• Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor [31].
• The inflammatory response to the peptide-functionalized SCK nanoparticles as measured by RT-PCR show statistically significant increases in the levels of both TNF-alpha and IL1-beta relative to tissue culture polystyrene (TCPS) [32].
• This method uses Abeta1-40 peptide, known for its high binding affinity to Abeta, magnetically labeled with either gadolinium (Gd) or monocrystalline iron oxide nanoparticles (MION) [33].
• Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1 [34].
• MMP-2 secretion was augmented only after 48 h for the highest concentrations of nanoparticles (10 and 20 microg/ml DNA content) [35].

Analytical, diagnostic and therapeutic context of Nanostructures

• The nanostructures of the PB-PEO micelles formed in an ionic liquid were directly visualized by cryogenic transmission electron microscopy (cryo-TEM) [36].
• Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins [37].
• An electrically contacted glucose dehydrogenase (GDH) enzyme electrode is fabricated by the reconstitution of the apo-GDH on pyrroloquinoline quinone (PQQ)-functionalized Au nanoparticles (Au-NPs), 1.4 nm, associated with a Au electrode [38].
• Atomic force microscopy was used to study the embedding of gold nanoparticles into the surface of polystyrene films [39].
• Excited-state metal-to-ligand charge transfer dynamics of a ruthenium(II) dye in solution and adsorbed on TiO2 nanoparticles from resonance Raman spectroscopy [40].

References