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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Nanostructures


Psychiatry related information on Nanostructures


High impact information on Nanostructures

  • We expect that the use of transition-metal nanoparticles to enhance surface electrochemical reactivity will lead to further improvements in the performance of lithium-ion batteries [8].
  • Mice receiving nanoparticles containing a dominant peanut allergen gene (pCMVArah2) produced secretory IgA and serum IgG2a [1].
  • Ultralong beltlike (or ribbonlike) nanostructures (so-called nanobelts) were successfully synthesized for semiconducting oxides of zinc, tin, indium, cadmium, and gallium by simply evaporating the desired commercial metal oxide powders at high temperatures [9].
  • These results, along with the observation that amyloid fibril formation by bacteria is highly orchestrated, suggest that fibril formation is an evolutionary conserved biological pathway used to generate natural product nanostructures [10].
  • Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [11].

Chemical compound and disease context of Nanostructures


Biological context of Nanostructures


Anatomical context of Nanostructures


Associations of Nanostructures with chemical compounds

  • Study of Nd3+, Pd2+, Pt4+, and Fe3+ dopant effect on photoreactivity of TiO2 nanoparticles [26].
  • Local administration of nanoparticles with incorporated dexamethasone significantly decreased neointimal formation [27].
  • Fluorescence superquenching is investigated for polyelectrolytes consisting of cyanine dye pendant polylysines ranging in number of polymer repeat units (N(PRU)) from 1 to 900, both in solution and after adsorption onto silica nanoparticles [28].
  • Alternatively, shell-crosslinked rod-shaped nanostructures with preserved morphology were obtained by the addition of the crosslinking agent before the addition of the carbodiimide, which allowed for the shell crosslinking to be performed at a faster rate than the morphological reorganization [29].
  • Ultrafine particles (smaller than about 0.1 microm) are often emitted from combustion and other high-temperature processes in the form of fractal-like aggregates composed of solid nanoparticles [30].

Gene context of Nanostructures


Analytical, diagnostic and therapeutic context of Nanostructures


  1. Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Roy, K., Mao, H.Q., Huang, S.K., Leong, K.W. Nat. Med. (1999) [Pubmed]
  2. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Zhang, W., Yang, H., Kong, X., Mohapatra, S., San Juan-Vergara, H., Hellermann, G., Behera, S., Singam, R., Lockey, R.F., Mohapatra, S.S. Nat. Med. (2005) [Pubmed]
  3. Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli. Lin, C.C., Yeh, Y.C., Yang, C.Y., Chen, C.L., Chen, G.F., Chen, C.C., Wu, Y.C. J. Am. Chem. Soc. (2002) [Pubmed]
  4. Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution. Konstan, M.W., Davis, P.B., Wagener, J.S., Hilliard, K.A., Stern, R.C., Milgram, L.J., Kowalczyk, T.H., Hyatt, S.L., Fink, T.L., Gedeon, C.R., Oette, S.M., Payne, J.M., Muhammad, O., Ziady, A.G., Moen, R.C., Cooper, M.J. Hum. Gene Ther. (2004) [Pubmed]
  5. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Chen, M., von Mikecz, A. Exp. Cell Res. (2005) [Pubmed]
  6. Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease. Härtig, W., Paulke, B.R., Varga, C., Seeger, J., Harkany, T., Kacza, J. Neurosci. Lett. (2003) [Pubmed]
  7. Studies on 2D hybrid films of half surfactant-covered Au nanoparticles at the air/water interface. Pang, S., Tetsuya, O., Tomoyuki, W., Kondo, T., Kawai, T. Journal of colloid and interface science. (2005) [Pubmed]
  8. Nano-sized transition-metal oxides as negative-electrode materials for lithium-ion batteries. Poizot, P., Laruelle, S., Grugeon, S., Dupont, L., Tarascon, J.M. Nature (2000) [Pubmed]
  9. Nanobelts of semiconducting oxides. Pan, Z.W., Dai, Z.R., Wang, Z.L. Science (2001) [Pubmed]
  10. Amyloid as a natural product. Kelly, J.W., Balch, W.E. J. Cell Biol. (2003) [Pubmed]
  11. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Lewin, M., Carlesso, N., Tung, C.H., Tang, X.W., Cory, D., Scadden, D.T., Weissleder, R. Nat. Biotechnol. (2000) [Pubmed]
  12. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Steiniger, S.C., Kreuter, J., Khalansky, A.S., Skidan, I.N., Bobruskin, A.I., Smirnova, Z.S., Severin, S.E., Uhl, R., Kock, M., Geiger, K.D., Gelperina, S.E. Int. J. Cancer (2004) [Pubmed]
  13. Treatment of experimental salmonellosis in mice with ampicillin-bound nanoparticles. Fattal, E., Youssef, M., Couvreur, P., Andremont, A. Antimicrob. Agents Chemother. (1989) [Pubmed]
  14. Intraocular injection of tamoxifen-loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis. de Kozak, Y., Andrieux, K., Villarroya, H., Klein, C., Thillaye-Goldenberg, B., Naud, M.C., Garcia, E., Couvreur, P. Eur. J. Immunol. (2004) [Pubmed]
  15. Sensitive assay for identification of methicillin-resistant Staphylococcus aureus, based on direct detection of genomic DNA by use of gold nanoparticle probes. Ramakrishnan, R., Buckingham, W., Domanus, M., Gieser, L., Klein, K., Kunkel, G., Prokhorova, A., Riccelli, P.V. Clin. Chem. (2004) [Pubmed]
  16. Chitosan for mucosal vaccination. van der Lubben, I.M., Verhoef, J.C., Borchard, G., Junginger, H.E. Adv. Drug Deliv. Rev. (2001) [Pubmed]
  17. Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Schwab, G., Chavany, C., Duroux, I., Goubin, G., Lebeau, J., Hélène, C., Saison-Behmoaras, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Hydroxyl stereochemistry and amine number within poly(glycoamidoamine)s affect intracellular DNA delivery. Liu, Y., Reineke, T.M. J. Am. Chem. Soc. (2005) [Pubmed]
  19. Effect of pd nanoparticle size on the catalytic hydrogenation of allyl alcohol. Wilson, O.M., Knecht, M.R., Garcia-Martinez, J.C., Crooks, R.M. J. Am. Chem. Soc. (2006) [Pubmed]
  20. Environmentally responsive "hairy" nanoparticles: mixed homopolymer brushes on silica nanoparticles synthesized by living radical polymerization techniques. Li, D., Sheng, X., Zhao, B. J. Am. Chem. Soc. (2005) [Pubmed]
  21. Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions. Wang, J., Gan, D., Lyon, L.A., El-Sayed, M.A. J. Am. Chem. Soc. (2001) [Pubmed]
  22. Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Anderson, S.A., Shukaliak-Quandt, J., Jordan, E.K., Arbab, A.S., Martin, R., McFarland, H., Frank, J.A. Ann. Neurol. (2004) [Pubmed]
  23. Efficiency of nanoparticles as a carrier system for antiviral agents in human immunodeficiency virus-infected human monocytes/macrophages in vitro. Bender, A.R., von Briesen, H., Kreuter, J., Duncan, I.B., Rübsamen-Waigmann, H. Antimicrob. Agents Chemother. (1996) [Pubmed]
  24. Self-organized lipid-porphyrin bilayer membranes in vesicular form: nanostructure, photophysical properties, and dioxygen coordination. Komatsu, T., Moritake, M., Nakagawa, A., Tsuchida, E. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  25. Detection and analysis of tumor fluorescence using a two-photon optical fiber probe. Thomas, T.P., Myaing, M.T., Ye, J.Y., Candido, K., Kotlyar, A., Beals, J., Cao, P., Keszler, B., Patri, A.K., Norris, T.B., Baker, J.R. Biophys. J. (2004) [Pubmed]
  26. Study of Nd3+, Pd2+, Pt4+, and Fe3+ dopant effect on photoreactivity of TiO2 nanoparticles. Shah, S.I., Li, W., Huang, C.P., Jung, O., Ni, C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty. Guzman, L.A., Labhasetwar, V., Song, C., Jang, Y., Lincoff, A.M., Levy, R., Topol, E.J. Circulation (1996) [Pubmed]
  28. Building highly sensitive dye assemblies for biosensing from molecular building blocks. Jones, R.M., Lu, L., Helgeson, R., Bergstedt, T.S., McBranch, D.W., Whitten, D.G. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Chemically induced supramolecular reorganization of triblock copolymer assemblies: trapping of intermediate states via a shell-crosslinking methodology. Ma, Q., Remsen, E.E., Clark, C.G., Kowalewski, T., Wooley, K.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Morphological properties of atmospheric aerosol aggregates. Xiong, C., Friedlander, S.K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  31. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Monsky, W.L., Fukumura, D., Gohongi, T., Ancukiewcz, M., Weich, H.A., Torchilin, V.P., Yuan, F., Jain, R.K. Cancer Res. (1999) [Pubmed]
  32. Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation. Becker, M.L., Bailey, L.O., Wooley, K.L. Bioconjug. Chem. (2004) [Pubmed]
  33. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Wadghiri, Y.Z., Sigurdsson, E.M., Sadowski, M., Elliott, J.I., Li, Y., Scholtzova, H., Tang, C.Y., Aguinaldo, G., Pappolla, M., Duff, K., Wisniewski, T., Turnbull, D.H. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2003) [Pubmed]
  34. Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1. Roschger, P., Matsuo, K., Misof, B.M., Tesch, W., Jochum, W., Wagner, E.F., Fratzl, P., Klaushofer, K. Bone (2004) [Pubmed]
  35. Metalloproteinase and cytokine production by THP-1 macrophages following exposure to chitosan-DNA nanoparticles. Chellat, F., Grandjean-Laquerriere, A., Le Naour, R., Fernandes, J., Yahia, L., Guenounou, M., Laurent-Maquin, D. Biomaterials (2005) [Pubmed]
  36. Self-assembly of block copolymer micelles in an ionic liquid. He, Y., Li, Z., Simone, P., Lodge, T.P. J. Am. Chem. Soc. (2006) [Pubmed]
  37. Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins. Abad, J.M., Mertens, S.F., Pita, M., Fernández, V.M., Schiffrin, D.J. J. Am. Chem. Soc. (2005) [Pubmed]
  38. Reconstitution of apo-glucose dehydrogenase on pyrroloquinoline quinone-functionalized au nanoparticles yields an electrically contacted biocatalyst. Zayats, M., Katz, E., Baron, R., Willner, I. J. Am. Chem. Soc. (2005) [Pubmed]
  39. Direct imaging of nanoparticle embedding to probe viscoelasticity of polymer surfaces. Teichroeb, J.H., Forrest, J.A. Phys. Rev. Lett. (2003) [Pubmed]
  40. Excited-state metal-to-ligand charge transfer dynamics of a ruthenium(II) dye in solution and adsorbed on TiO2 nanoparticles from resonance Raman spectroscopy. Shoute, L.C., Loppnow, G.R. J. Am. Chem. Soc. (2003) [Pubmed]
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