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MeSH Review


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Disease relevance of Microspheres


Psychiatry related information on Microspheres


High impact information on Microspheres

  • The major areas of normal coronary physiological research since Berne's 1964 review have been the measurement of ventricular transmural blood flow distribution with microspheres, the adenosine hypothesis of local metabolic control of coronary blood flow, and the autonomic control of coronary blood flow [11].
  • HeLa cells in early S phase were encapsulated in agarose microbeads, permeabilized, and incubated with biotin-11-dUTP in a "physiological" buffer [12].
  • Quick-freeze, deep-etch EM was used to analyze MTs polymerized from tubulin and cross-linked to latex microspheres by kinesin [13].
  • Here we describe the systematic engineering of multi-component, environmentally responsive hydrogel microspheres, coated with a lipid bilayer to mimic more closely the natural secretory granule [14].
  • High-resolution in situ hybridization revealed that mRNA and ribosomes rapidly and specifically localized to FACs that form when cells bind to ECM-coated microbeads [15].

Chemical compound and disease context of Microspheres

  • To identify ganglion cells that send axons to the SC in development, rhodamine-labeled microspheres were deposited in the SC at embryonic day (E) 38, E43, or postnatal day (P) 4 [16].
  • Measurements of hemodynamics, regional myocardial blood flow (microspheres), lactate and oxygen metabolism, and whole blood viscosity were made at control and after two successive 10 min intracoronary infusions of adenosine (400 and 800 micrograms/min) distal to the stenosis [17].
  • In 16 anesthetized open-chest dogs, validation of this technique was performed at baseline, reduced (stenosis), and hyperemic (dipyridamole) flow states by means of the radionuclide-labeled microsphere reference withdrawal technique [18].
  • To determine the relation between regional myocardial blood flow, contractile function, and myocardial lactate release during mild-to-moderate regional myocardial ischemia, nine open-chest swine were instrumented for measurement of regional myocardial blood flow (microsphere method), contractile function (sonomicrometry), and hemodynamics [19].
  • Myocardial infarct size was determined by triphenyl tetrazolium chloride; transmural myocardial blood flow, by radioactive microspheres [20].

Biological context of Microspheres


Anatomical context of Microspheres


Associations of Microspheres with chemical compounds


Gene context of Microspheres

  • A low level of jerkiness was also observed in the rolling of microbeads conjugated with L-selectin, a model system lacking the mechanism for L-selectin shedding [35].
  • However, cell dissociation and bead release induced by PF-IgGs was not caused by direct steric hindrance of Dsg1 transinteraction, as demonstrated by single molecule atomic force measurements and by laser trapping of surface-bound Dsg1-coated microbeads [36].
  • To study, in isolation, the interaction of PSGL-1 with P- and E-selectin under flow, we developed an in vitro model in which various recombinant regions of extracellular PSGL-1 were coupled to 10-microm-diameter microspheres [37].
  • TLN mediates the uptake of microbeads concomitant with actin and PIP2 recruitment, indicating a phagocytic origin of TLN accumulations [38].
  • METHODS AND RESULTS: Macrophages were loaded with fluorescent microspheres and injected intravenously into 40-week-old apolipoprotein E-deficient mice [39].

Analytical, diagnostic and therapeutic context of Microspheres


  1. Magnetic microspheres prepared by redox polymerization used in a cell separation based on gangliosides. Kronick, P.L., Campbell, G.L., Joseph, K. Science (1978) [Pubmed]
  2. Transient morphological features of identified ganglion cells in living fetal and neonatal retina. Ramoa, A.S., Campbell, G., Shatz, C.J. Science (1987) [Pubmed]
  3. Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Geschwind, J.F., Salem, R., Carr, B.I., Soulen, M.C., Thurston, K.G., Goin, K.A., Van Buskirk, M., Roberts, C.A., Goin, J.E. Gastroenterology (2004) [Pubmed]
  4. Tumor remission in Yoshida sarcoma-bearing rts by selective targeting of magnetic albumin microspheres containing doxorubicin. Widder, K.J., Morris, R.M., Poore, G., Howard, D.P., Senyei, A.E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. Quantification of myocardial injury produced by temporary coronary artery occlusion and reflow with technetium-99m-pyrophosphate. Jansen, D.E., Corbett, J.R., Buja, L.M., Hansen, C., Ugolini, V., Parkey, R.W., Willerson, J.T. Circulation (1987) [Pubmed]
  6. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Quattrochi, J.J., Mamelak, A.N., Madison, R.D., Macklis, J.D., Hobson, J.A. Science (1989) [Pubmed]
  7. A new syndrome of mental retardation and epilepsy characterized by dense microsphere accumulation. George, D.H., Munoz, D.G. Acta Neuropathol. (1991) [Pubmed]
  8. Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice. Brayden, D.J., Templeton, L., McClean, S., Barbour, R., Huang, J., Nguyen, M., Ahern, D., Motter, R., Johnson-Wood, K., Vasquez, N., Schenk, D., Seubert, P. Vaccine (2001) [Pubmed]
  9. Renaturation of reduced ribonuclease A with a microsphere-induced refolding system. Shimizu, H., Fujimoto, K., Kawaguchi, H. Biotechnol. Prog. (2000) [Pubmed]
  10. Egg albumin microspheres containing paracetamol for oral administration. II. In vivo investigation. Torrado, J.J., Illum, L., Cadorniga, R., Davis, S.S. Journal of microencapsulation. (1990) [Pubmed]
  11. Coronary physiology. Feigl, E.O. Physiol. Rev. (1983) [Pubmed]
  12. Visualization of replication factories attached to nucleoskeleton. Hozák, P., Hassan, A.B., Jackson, D.A., Cook, P.R. Cell (1993) [Pubmed]
  13. Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration. Hirokawa, N., Pfister, K.K., Yorifuji, H., Wagner, M.C., Brady, S.T., Bloom, G.S. Cell (1989) [Pubmed]
  14. A synthetic mimic of the secretory granule for drug delivery. Kiser, P.F., Wilson, G., Needham, D. Nature (1998) [Pubmed]
  15. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Chicurel, M.E., Singer, R.H., Meyer, C.J., Ingber, D.E. Nature (1998) [Pubmed]
  16. Retinal ganglion beta cells project transiently to the superior colliculus during development. Ramoa, A.S., Campbell, G., Shatz, C.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Effect of a reduction in blood viscosity on maximal myocardial oxygen delivery distal to a moderate coronary stenosis. Most, A.S., Ruocco, N.A., Gewirtz, H. Circulation (1986) [Pubmed]
  18. Measurement of regional myocardial perfusion and mass by subselective hydrogen infusion and washout techniques: a validation study. Grines, C.L., Mancini, G.B., McGillem, M.J., Gallagher, K.P., Vogel, R.A. Circulation (1987) [Pubmed]
  19. Myocardial lactate release during ischemia in swine. Relation to regional blood flow. Guth, B.D., Wisneski, J.A., Neese, R.A., White, F.C., Heusch, G., Mazer, C.D., Gertz, E.W. Circulation (1990) [Pubmed]
  20. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Mizumura, T., Nithipatikom, K., Gross, G.J. Circulation (1995) [Pubmed]
  21. Biologically erodable microspheres as potential oral drug delivery systems. Mathiowitz, E., Jacob, J.S., Jong, Y.S., Carino, G.P., Chickering, D.E., Chaturvedi, P., Santos, C.A., Vijayaraghavan, K., Montgomery, S., Bassett, M., Morrell, C. Nature (1997) [Pubmed]
  22. Local regulation of blood flow in the feline jejunum. A possible role for endoluminally released substance P. Yeo, C.J., Jaffe, B.M., Zinner, M.J. J. Clin. Invest. (1982) [Pubmed]
  23. Degradation of circulating DNA by extracorporeal circulation over nuclease immobilized on nylon microcapsules. Terman, D.S., Tavel, A., Tavel, T., Petty, D., Harbeck, R., Buffaloe, G., Carr, R. J. Clin. Invest. (1976) [Pubmed]
  24. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Hennenberg, M., Biecker, E., Trebicka, J., Jochem, K., Zhou, Q., Schmidt, M., Jakobs, K.H., Sauerbruch, T., Heller, J. Gastroenterology (2006) [Pubmed]
  25. Different fates of phagocytosed particles after delivery into macrophage lysosomes. Oh, Y.K., Swanson, J.A. J. Cell Biol. (1996) [Pubmed]
  26. Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity. Celada, A., Gray, P.W., Rinderknecht, E., Schreiber, R.D. J. Exp. Med. (1984) [Pubmed]
  27. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. Qu, C., Edwards, E.W., Tacke, F., Angeli, V., Llodrá, J., Sanchez-Schmitz, G., Garin, A., Haque, N.S., Peters, W., van Rooijen, N., Sanchez-Torres, C., Bromberg, J., Charo, I.F., Jung, S., Lira, S.A., Randolph, G.J. J. Exp. Med. (2004) [Pubmed]
  28. Relationship between regional myocardial blood flow and thallium-201 distribution in the presence of coronary artery stenosis and dipyridamole-induced vasodilation. Mays, A.E., Cobb, F.R. J. Clin. Invest. (1984) [Pubmed]
  29. Blood flow to the rabbit pancreas with special reference to the islets of Langerhans. Lifson, N., Kramlinger, K.G., Mayrand, R.R., Lender, E.J. Gastroenterology (1980) [Pubmed]
  30. Removal of neuroblastoma cells from bone marrow with monoclonal antibodies conjugated to magnetic microspheres. Treleaven, J.G., Gibson, F.M., Ugelstad, J., Rembaum, A., Philip, T., Caine, G.D., Kemshead, J.T. Lancet (1984) [Pubmed]
  31. Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection. Whittum-Hudson, J.A., An, L.L., Saltzman, W.M., Prendergast, R.A., MacDonald, A.B. Nat. Med. (1996) [Pubmed]
  32. Pulmonary perfusion defect and bronchial artery collateral blood flow. Neches, W.H., Weiss, F.H., Park, S.C., Lenox, C.C., Zuberbuhler, J.R., Carroll, R.G. JAMA (1977) [Pubmed]
  33. A myeloma paraprotein with specificity for platelet glycoprotein IIIa in a patient with a fatal bleeding disorder. DiMinno, G., Coraggio, F., Cerbone, A.M., Capitanio, A.M., Manzo, C., Spina, M., Scarpato, P., Dattoli, G.M., Mattioli, P.L., Mancini, M. J. Clin. Invest. (1986) [Pubmed]
  34. Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats. Fernández, M., García-Pagán, J.C., Casadevall, M., Bernadich, C., Piera, C., Whittle, B.J., Piqué, J.M., Bosch, J., Rodés, J. Gastroenterology (1995) [Pubmed]
  35. L-selectin shedding regulates leukocyte recruitment. Hafezi-Moghadam, A., Thomas, K.L., Prorock, A.J., Huo, Y., Ley, K. J. Exp. Med. (2001) [Pubmed]
  36. Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction. Waschke, J., Bruggeman, P., Baumgartner, W., Zillikens, D., Drenckhahn, D. J. Clin. Invest. (2005) [Pubmed]
  37. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. Goetz, D.J., Greif, D.M., Ding, H., Camphausen, R.T., Howes, S., Comess, K.M., Snapp, K.R., Kansas, G.S., Luscinskas, F.W. J. Cell Biol. (1997) [Pubmed]
  38. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. Esselens, C., Oorschot, V., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Saftig, P., De Strooper, B., Klumperman, J., Annaert, W. J. Cell Biol. (2004) [Pubmed]
  39. Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. Patel, S.S., Thiagarajan, R., Willerson, J.T., Yeh, E.T. Circulation (1998) [Pubmed]
  40. A month-long effect from a single injection of microencapsulated human growth hormone. Johnson, O.L., Cleland, J.L., Lee, H.J., Charnis, M., Duenas, E., Jaworowicz, W., Shepard, D., Shahzamani, A., Jones, A.J., Putney, S.D. Nat. Med. (1996) [Pubmed]
  41. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. Makrigiorgos, G.M., Adelstein, S.J., Kassis, A.I. JAMA (1990) [Pubmed]
  42. A ferret model of acute multifocal gastrointestinal infarction. Hudson, M., Piasecki, C., Sankey, E.A., Sim, R., Wakefield, A.J., More, L.J., Sawyerr, A.M., Dhillon, A.P., Pounder, R.E. Gastroenterology (1992) [Pubmed]
  43. The effect of left atrial-to-aortic assistance on infarct size. Laks, H., Ott, R.A., Standeven, J.W., Hahn, J.W., Blair, O.M., Willman, V.L. Circulation (1977) [Pubmed]
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