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Chemical Compound Review:

SureCN8413515 1-(5-tetradecoxy-2- furyl)ethanone

Synonyms: RMI-15731, KST-1B5680, NSC-317936, NSC317936, AR-1B2352, ...

Ash, R.J. et al., Ninomiya, Y. et al., Ishitsuka, H. et al.

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Disease relevance of Rmi 15731

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone) is a new antiviral compound with activity specific for rhinoviruses [1].
RMI 15,731 appears to be a promising new antirhinovirus compound for clinical evaluation since it (i) blocks intracellular virus synthesis (without cellular toxicity), and (ii) directly inactivates virions [1].

High impact information on Rmi 15731

Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime [2].
Ro 09-0410, 4',6-dichloroflavan, and RMI-15,731 were active preferentially against human rhinovirus [2].

Chemical compound and disease context of Rmi 15731

Chalcone Ro 09-0410, 4',6-dichloroflavan (DCF) and RMI-15,731, which were active against rhinoviruses, inactivated the virus directly [3].

References

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound. Ash, R.J., Parker, R.A., Hagan, A.C., Mayer, G.D. Antimicrob. Agents Chemother. (1979) [Pubmed]
Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime. Ninomiya, Y., Aoyama, M., Umeda, I., Suhara, Y., Ishitsuka, H. Antimicrob. Agents Chemother. (1985) [Pubmed]
Molecular basis of drug resistance to new antirhinovirus agents. Ishitsuka, H., Ninomiya, Y., Suhara, Y. J. Antimicrob. Chemother. (1986) [Pubmed]

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