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Chemical Compound Review:

SureCN9141918 (E)-1-(4-ethoxy-2-hydroxy-6- methoxy...

Synonyms: AC1O5QIM, Ro-09410, Ro-09-0410, Ro 09-0410, 76554-66-0, ...

Ishitsuka, H. et al., Ninomiya, Y. et al., Almela, M.J. et al., Yasin, S.R. et al., Ninomiya, Y. et al., et al.

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Disease relevance of Ro-09410

A number of inhibitors of poliovirus growth such as WIN 51711 6-(3,4-dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile (DEPC) and Ro 09-0410 specifically block the uncoating step of poliovirus but have no effect on attachment or entry of poliovirus particles into cells [1].
Ro 09-0410 inactivated rhinoviruses in direct dose-, time-, and temperature-dependent fashion [2].
These results indicate (i) that Ro 09-0410, 4',6-dichloroflavan, and RMI-15,731 exert their activities through the same mode of action, namely, binding to or interaction with some specific site on the viral capsid protein, and (ii) that the binding or interaction sites for these three agents are either the same or very close to each other [3].
Ro 09-0410 had a high activity against rhinoviruses but no activity against other picornaviruses [2].
These results suggest that Ro 09-0410 binds to the HRV-2 virion and prevents viral replication in the cell [4].

High impact information on Ro-09410

Mutants of human rhinovirus type 2 (HRV-2) resistant to and dependent on the antirhinoviral compound chalcone Ro 09-0410 were selected in cell culture under clean laboratory conditions [5].
Of 53 rhinovirus serotypes so far tested, 46 were susceptible to Ro 09-0410 in HeLa cell cultures [2].

Analytical, diagnostic and therapeutic context of Ro-09410

Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers [6].

References

Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles. Almela, M.J., González, M.E., Carrasco, L. J. Virol. (1991) [Pubmed]
Direct and specific inactivation of rhinovirus by chalcone Ro 09-0410. Ishitsuka, H., Ninomiya, Y.T., Ohsawa, C., Fujiu, M., Suhara, Y. Antimicrob. Agents Chemother. (1982) [Pubmed]
Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime. Ninomiya, Y., Aoyama, M., Umeda, I., Suhara, Y., Ishitsuka, H. Antimicrob. Agents Chemother. (1985) [Pubmed]
Antivirus agent, Ro 09-0410, binds to rhinovirus specifically and stabilizes the virus conformation. Ninomiya, Y., Ohsawa, C., Aoyama, M., Umeda, I., Suhara, Y., Ishitsuka, H. Virology (1984) [Pubmed]
Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410. Yasin, S.R., al-Nakib, W., Tyrrell, D.A. Antimicrob. Agents Chemother. (1990) [Pubmed]
Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers. Al-Nakib, W., Higgins, P.G., Barrow, I., Tyrrell, D.A., Lenox-Smith, I., Ishitsuka, H. J. Antimicrob. Chemother. (1987) [Pubmed]

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