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Chemical Compound Review:

AG-K-73578 2-(5-oxo-4H-furan-2- yl)ethanoic acid

Synonyms: CHEBI:18267, CTK7J1994, AKOS006376286, AC1L18HL, C03586, ...

Iwagami, S.G. et al., Murakami, S. et al., McCorkle, G.M. et al., Hartnett, G.B. et al., Yeh, W.K. et al.

Murakami, Takashima, Takemoto, Takenaka, Shinke, Aoki,

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Disease relevance of C03586

Evolutionary divergence of co-selected beta-ketoadipate enol-lactone hydrolases in Acinetobacter calcoaceticus [1].
In this report, we describe the purification of Pseudomonas beta-ketoadipate enol-lactone hydrolase and present evidence indicating that the protein is a trimer composed of identical 11,000-dalton subunits [2].
Analysis of the cluster revealed the presence of a pcaL homologue which encodes a fused gamma-carboxymuconolactone decarboxylase/beta-ketoadipate enol-lactone hydrolase previously identified in the pca gene cluster from Rhodococcus opacus 1CP [3].

High impact information on C03586

The catA1 gene was clustered with catB1 encoding MC I, catC1 encoding muconolactone isomerase (MI), catD encoding beta-ketoadipate enol-lactone hydrolase (ELH), and ORFR1 encoding a putative LysR-type regulator [4].
This report presents the 2754-nucleotide (nt) sequence of a HindIII restriction fragment containing pcaD, the 801-bp gene encoding beta-ketoadipate enol-lactone hydrolase I [5].

References

Evolutionary divergence of co-selected beta-ketoadipate enol-lactone hydrolases in Acinetobacter calcoaceticus. Yeh, W.K., Fletcher, P., Ornston, L.N. J. Biol. Chem. (1980) [Pubmed]
Repetitions in the NH2-terminal amino acid sequence of beta-ketoadipate enol-lactone hydrolase from Pseudomonas putida. McCorkle, G.M., Yeh, W.K., Fletcher, P., Ornston, L.N. J. Biol. Chem. (1980) [Pubmed]
Characterization of the protocatechuic acid catabolic gene cluster from Streptomyces sp. strain 2065. Iwagami, S.G., Yang, K., Davies, J. Appl. Environ. Microbiol. (2000) [Pubmed]
Cloning and sequence analysis of two catechol-degrading gene clusters from the aniline-assimilating bacterium Frateuria species ANA-18. Murakami, S., Takashima, A., Takemoto, J., Takenaka, S., Shinke, R., Aoki, K. Gene (1999) [Pubmed]
Acquisition of apparent DNA slippage structures during extensive evolutionary divergence of pcaD and catD genes encoding identical catalytic activities in Acinetobacter calcoaceticus. Hartnett, G.B., Ornston, L.N. Gene (1994) [Pubmed]

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