Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AGN-PC-00OAFA 2-(carboxymethyl)-5-oxo- furan-2-carboxylic...

Synonyms: AG-K-79748, SureCN2203488, CHEBI:16993, CTK4B7949, AR-1E1832, ...

Habe, H. et al., Yeh, W.K. et al., Eulberg, D. et al., Yeh, W.K. et al., Parke, D.

Habe, Chung, Ishida, Kasuga, Ide, Takemura, Nojiri, Yamane, Omori,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of gamma-carboxymuconolactone

gamma-Carboxymuconolactone decarboxylase (EC 4.1.1.44) from Azotobacter vinelandii resembled the isofunctional enzymes from Acinetobacter calcoaceticus and Pseudomonas putida [1].
Characterization of a protocatechuate catabolic gene cluster from Rhodococcus opacus 1CP: evidence for a merged enzyme with 4-carboxymuconolactone-decarboxylating and 3-oxoadipate enol-lactone-hydrolyzing activity [2].
Structural comparison of gamma-carboxymuconolactone decarboxylase and muconolactone isomerase from Pseudomonas putida [3].

High impact information on gamma-carboxymuconolactone

gamma-Carboxymuconolactone decarobxylase (EC 4.1.1.44) and muconolactone isomerase (EC 5.3.3.4) mediate chemically analogous reactions in bacteria [4].
Homologies in the NH2-terminal amino acid sequences of gamma-carboxymuconolactone decarboxylases and muconolactone isomerases [4].

Associations of gamma-carboxymuconolactone with other chemical compounds

The gene encoding beta-ketoadipate enol-lactone hydrolase (pcaD) was not fused to the next gene, which encodes gamma-carboxymuconolactone decarboxylase (pcaC), in strain DBF63, even though the presence of the pcaL gene (the fusion of pcaD and pcaC) within a pca gene cluster has been thought to be a Gram-positive trait [5].

References

Evolutionary relationships among gamma-carboxymuconolactone decarboxylases. Yeh, W.K., Durham, D.R., Fletcher, P., Ornston, L.N. J. Bacteriol. (1981) [Pubmed]
Characterization of a protocatechuate catabolic gene cluster from Rhodococcus opacus 1CP: evidence for a merged enzyme with 4-carboxymuconolactone-decarboxylating and 3-oxoadipate enol-lactone-hydrolyzing activity. Eulberg, D., Lakner, S., Golovleva, L.A., Schlömann, M. J. Bacteriol. (1998) [Pubmed]
Structural comparison of gamma-carboxymuconolactone decarboxylase and muconolactone isomerase from Pseudomonas putida. Parke, D. Biochim. Biophys. Acta (1979) [Pubmed]
Homologies in the NH2-terminal amino acid sequences of gamma-carboxymuconolactone decarboxylases and muconolactone isomerases. Yeh, W.K., Fletcher, P., Ornston, N. J. Biol. Chem. (1980) [Pubmed]
The fluorene catabolic linear plasmid in Terrabacter sp. strain DBF63 carries the beta-ketoadipate pathway genes, pcaRHGBDCFIJ, also found in proteobacteria. Habe, H., Chung, J.S., Ishida, A., Kasuga, K., Ide, K., Takemura, T., Nojiri, H., Yamane, H., Omori, T. Microbiology (Reading, Engl.) (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.