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Chemical Compound Review:

CCRIS 1576 (2S)-2-amino-3-(2-chloro- 1,1,2-trifluoro...

Synonyms: AG-H-95617, AC1Q4HOG, CTK5H8788, AR-1J3081, LS-188873, ...

Vamvakas, S. et al., Hayden, P.J. et al.

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High impact information on CCRIS 1576

Rat kidney mitochondria were incubated with the 35S-labeled conjugates S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC), S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (CTFC), S-(1,2-dichlorovinyl)-L-cysteine, and S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine [1].
Benzyl 2-chloro-1,1,2-trifluoroethyl sulfide, which also undergoes benzylic hydroxylation, was negative in the Ames-Test; this is in agreement with the observed lack of mutagenicity of the corresponding S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine [2].

References

Formation of mitochondrial phospholipid adducts by nephrotoxic cysteine conjugate metabolites. Hayden, P.J., Welsh, C.J., Yang, Y., Schaefer, W.H., Ward, A.J., Stevens, J.L. Chem. Res. Toxicol. (1992) [Pubmed]
Mutagenicity of benzyl S-haloalkyl and S-haloalkenyl sulfides in the Ames-test. Vamvakas, S., Dekant, W., Anders, M.W. Biochem. Pharmacol. (1989) [Pubmed]

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