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Chemical Compound Review

sulphide     sulfide

Synonyms: SULFIDE, sulfanediide, sulfide(2-), sulfur(2-), Sulphur (2-), ...
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Disease relevance of sulfide

  • The structure of the heterodimeric flavocytochrome c sulfide dehydrogenase from Chromatium vinosum was determined at a resolution of 2.53 angstroms [1].
  • Cells of nickel sulfide-induced rhabdomyosarcomas were studied with the electron microscope [2].
  • We studied the effect of sulindac, and its metabolite sulindac sulfide, on the proliferation of HT-29 colon adenocarcinoma cells [3].
  • Injection of an agent (hexachlorotetra-fluorobutane) that induced lung infarction did not increase the proportion of animals having lesions, nor did it alter the type of lesions found in animals exposed to nickel sulfide [4].
  • These four painters may have been heavily exposed to mercury sulphide, cadmium sulphide, arsenic sulphide, lead, antimony, tin, cobalt, manganese, and chromium, the metals of the bright and clear colours, and exposure to these metals may be of importance in the development of inflammatory rheumatic diseases [5].

Psychiatry related information on sulfide

  • Oral malodor was assessed by measurement of peak and steady-state volatile sulphide levels with a portable sulphide monitor and by organoleptic measurement of whole-mouth, tongue dorsum, and interproximal dental odors by two independent judges [6].
  • The analytical properties (range of determination, sensitivity, selectivity, response time) of the copper (I) sulfide-based sensors were comparable with those for conventional ion-selective electrodes [7].
  • Changes in the intensity of sulfide staining in fronto-parietal cortex of the rat following nucleus basalis magnocellularis lesions: possible relevance to Alzheimer's disease [8].
  • Variables included self-evaluation of participants' own breath odor (gener ally and current), an organoleptic evaluation of an impartial judge of odor, measurement of the volatile sulfide level in the oral cavity, and questionnaires referring to psychopathologic symptoms and body-image characteristics [9].

High impact information on sulfide

  • The high-pressure, high-temperature data presented here show conclusively that potassium enters iron sulphide melts in a strongly temperature-dependent fashion and that (40)K can serve as a substantial heat source in the cores of the Earth and Mars [10].
  • Here we report that the NSAIDs ibuprofen, indomethacin and sulindac sulphide preferentially decrease the highly amyloidogenic Abeta42 peptide (the 42-residue isoform of the amyloid-beta peptide) produced from a variety of cultured cells by as much as 80% [11].
  • Here we report in situ laser-ablation analyses of sulphides in mantle-derived rocks which show that these sulphides do not have chondritic HSE patterns, but that different generations of sulphide within single samples show extreme variability in the relative abundances of HSEs [12].
  • On the basis of 16S ribosomal DNA sequence data, these bacteria are closely related to the marine filamentous sulfur bacteria Thioploca, abundant in the upwelling area off Chile and Peru. Similar to Thioploca, the giant bacteria oxidize sulfide with nitrate that is accumulated to </=800 millimolar in a central vacuole [13].
  • This review analyzes four such structures of catalytic antibodies that catalyze markedly different reactions, including ester hydrolysis, sulfide oxidation, and a pericyclic rearrangement [14].

Chemical compound and disease context of sulfide


Biological context of sulfide


Anatomical context of sulfide


Associations of sulfide with other chemical compounds

  • At low PH2, H2 production greatly exceeded consumption and there was negligible accumulation of the products of H2 catabolism, methane and sulfide [26].
  • Expression of other Bcl-2 family members was unchanged after sulindac sulfide [23].
  • We have identified a cadmium sensitive S. pombe mutant deficient in the accumulation of a sulfide-containing phytochelatin-cadmium complex, and have isolated the gene, designated hmt1, that complements this mutant [27].
  • Biological methyl donors to cobalamin include N5-methyltetrahydrofolate, other methylamines, methanol, aromatic methyl ethers, acetate, and dimethyl sulfide [28].
  • This Account focuses on recent developments of the chemistry of metal thio- and selenocarboxylates in our laboratory and potential use of some of these compounds as single-source precursors for making metal sulfide and selenide bulk materials, thin films, and nanoparticles [29].

Gene context of sulfide


Analytical, diagnostic and therapeutic context of sulfide

  • We interpret the silicate-enclosed sulphides as the residues of melting processes and interstitial sulphides as the crystallization products of sulphide-bearing (metasomatic) fluids [12].
  • In the present work, cross-linking, SDS/PAGE, and size exclusion chromatography revealed that SplB protein dimerized when incubated with iron and sulfide under anaerobic reducing conditions [34].
  • Titrations using visible spectroscopy were consistent with the oxidation and reduction of the protein each requiring two electrons/molecule, suggesting that these metals and the sulfide are arranged in two redox active centers [35].
  • It has been determined from steady state kinetic studies using the sulfide ion selective electrode that O-acetylserine sulfhydrylase catalyzes a Bi Bi Ping Pong reaction between O-acetyl-L-serine and sulfide [36].
  • The combination of radioautography and Timm's sulfide-silver staining provides the specificity and resolution needed for ultrastructural evaluation of lead absorption and should be useful in further studies of lead metabolism [37].


  1. The structure of flavocytochrome c sulfide dehydrogenase from a purple phototrophic bacterium. Chen, Z.W., Koh, M., Van Driessche, G., Van Beeumen, J.J., Bartsch, R.G., Meyer, T.E., Cusanovich, M.A., Mathews, F.S. Science (1994) [Pubmed]
  2. Fine structure of dividing cells and of nondividing, differentiating cells of nickel sulfide-induced rhabdomyosarcomas. Bruni, C., Rust, J.N. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. Shiff, S.J., Qiao, L., Tsai, L.L., Rigas, B. J. Clin. Invest. (1995) [Pubmed]
  4. Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats. Ottolenghi, A.D., Haseman, J.K., Payne, W.W., Falk, H.L., MacFarland, H.N. J. Natl. Cancer Inst. (1975) [Pubmed]
  5. Rheumatic disease, heavy-metal pigments, and the Great Masters. Pedersen, L.M., Permin, H. Lancet (1988) [Pubmed]
  6. Reproducibility and sensitivity of oral malodor measurements with a portable sulphide monitor. Rosenberg, M., Kulkarni, G.V., Bosy, A., McCulloch, C.A. J. Dent. Res. (1991) [Pubmed]
  7. Screen-printed copper ion-selective electrodes. Koncki, R., Tymecki, L., Zwierkowska, E., Glab, S. Fresenius' journal of analytical chemistry. (2000) [Pubmed]
  8. Changes in the intensity of sulfide staining in fronto-parietal cortex of the rat following nucleus basalis magnocellularis lesions: possible relevance to Alzheimer's disease. Caporali, M.G., Bronzetti, E., Ciriaco, E., Niglio, T., Ricci, A., Scotti de Carolis, A., Amenta, F. Archives of gerontology and geriatrics. (1991) [Pubmed]
  9. Self-perception of breath odor: role of body image and psychopathologic traits. Eli, I., Koriat, H., Baht, R., Rosenberg, M. Perceptual and motor skills. (2000) [Pubmed]
  10. Experimental evidence that potassium is a substantial radioactive heat source in planetary cores. Murthy, V.R., van Westrenen, W., Fei, Y. Nature (2003) [Pubmed]
  11. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Weggen, S., Eriksen, J.L., Das, P., Sagi, S.A., Wang, R., Pietrzik, C.U., Findlay, K.A., Smith, T.E., Murphy, M.P., Bulter, T., Kang, D.E., Marquez-Sterling, N., Golde, T.E., Koo, E.H. Nature (2001) [Pubmed]
  12. Non-chondritic distribution of the highly siderophile elements in mantle sulphides. Alard, O., Griffin, W.L., Lorand, J.P., Jackson, S.E., O'Reilly, S.Y. Nature (2000) [Pubmed]
  13. Dense populations of a giant sulfur bacterium in Namibian shelf sediments. Schulz, H.N., Brinkhoff, T., Ferdelman, T.G., Mariné, M.H., Teske, A., Jorgensen, B.B. Science (1999) [Pubmed]
  14. The structural and functional basis of antibody catalysis. Wade, H., Scanlan, T.S. Annual review of biophysics and biomolecular structure. (1997) [Pubmed]
  15. Hydrogen sulfide intoxication. A case report and discussion of treatment. Stine, R.J., Slosberg, B., Beacham, B.E. Ann. Intern. Med. (1976) [Pubmed]
  16. Monoclonal antibodies to human estrogen receptor. Greene, G.L., Nolan, C., Engler, J.P., Jensen, E.V. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  17. Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide. Wargovich, M.J., Woods, C., Eng, V.W., Stephens, L.C., Gray, K. Cancer Res. (1988) [Pubmed]
  18. EPR and Mössbauer spectroscopic studies on enoate reductase. Caldeira, J., Feicht, R., White, H., Teixeira, M., Moura, J.J., Simon, H., Moura, I. J. Biol. Chem. (1996) [Pubmed]
  19. Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes. McDevitt, C.A., Hugenholtz, P., Hanson, G.R., McEwan, A.G. Mol. Microbiol. (2002) [Pubmed]
  20. Animal adaptations for tolerance and exploitation of poisonous sulfide. Grieshaber, M.K., Völkel, S. Annu. Rev. Physiol. (1998) [Pubmed]
  21. Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Yu, W., Farrell, R.A., Stillman, D.J., Winge, D.R. Mol. Cell. Biol. (1996) [Pubmed]
  22. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Piazza, G.A., Rahm, A.L., Krutzsch, M., Sperl, G., Paranka, N.S., Gross, P.H., Brendel, K., Burt, R.W., Alberts, D.S., Pamukcu, R. Cancer Res. (1995) [Pubmed]
  23. A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. Arber, N., Han, E.K., Sgambato, A., Piazza, G.A., Delohery, T.M., Begemann, M., Weghorst, C.M., Kim, N.H., Pamukcu, R., Ahnen, D.J., Reed, J.C., Weinstein, I.B., Holt, P.R. Gastroenterology (1997) [Pubmed]
  24. Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Mahmoud, N.N., Bilinski, R.T., Churchill, M.R., Edelmann, W., Kucherlapati, R., Bertagnolli, M.M. Cancer Res. (1999) [Pubmed]
  25. Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. Moon, E.Y., Lerner, A. Cancer Res. (2002) [Pubmed]
  26. Factors affecting hydrogen production and consumption by human fecal flora. The critical roles of hydrogen tension and methanogenesis. Strocchi, A., Levitt, M.D. J. Clin. Invest. (1992) [Pubmed]
  27. Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. Ortiz, D.F., Kreppel, L., Speiser, D.M., Scheel, G., McDonald, G., Ow, D.W. EMBO J. (1992) [Pubmed]
  28. Cobalamin-dependent methyltransferases. Matthews, R.G. Acc. Chem. Res. (2001) [Pubmed]
  29. Chemistry of metal thio- and selenocarboxylates: precursors for metal sulfide/selenide materials, thin films, and nanocrystals. Vittal, J.J., Ng, M.T. Acc. Chem. Res. (2006) [Pubmed]
  30. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Taylor, M.T., Lawson, K.R., Ignatenko, N.A., Marek, S.E., Stringer, D.E., Skovan, B.A., Gerner, E.W. Cancer Res. (2000) [Pubmed]
  31. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Molina, M.A., Sitja-Arnau, M., Lemoine, M.G., Frazier, M.L., Sinicrope, F.A. Cancer Res. (1999) [Pubmed]
  32. Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells. Lim, J.T., Joe, A.K., Suzui, M., Shimizu, M., Masuda, M., Weinstein, I.B. Clin. Cancer Res. (2006) [Pubmed]
  33. Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver. Arora, A., Seth, K., Shukla, Y. Carcinogenesis (2004) [Pubmed]
  34. The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase. Rebeil, R., Nicholson, W.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  35. Characterization of a tungsten-iron-sulfur protein exhibiting novel spectroscopic and redox properties from the hyperthermophilic archaebacterium Pyrococcus furiosus. Mukund, S., Adams, M.W. J. Biol. Chem. (1990) [Pubmed]
  36. A reaction mechanism from steady state kinetic studies for O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2. Cook, P.F., Wedding, R.T. J. Biol. Chem. (1976) [Pubmed]
  37. Ultrastructural radioautography and cytochemistry of lead absorption. Parmley, R.T., Barton, J.C., Conrad, M.E., Austin, R.L. Am. J. Pathol. (1979) [Pubmed]
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