The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

DCVC     2-amino-3-[(Z)-1,2- dichloroethenyl]sulfany...

Synonyms: CHEMBL1697700, NSC-15830, NSC15830, AC1NV8S8, AC1Q3HC1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DCVC


High impact information on DCVC


Chemical compound and disease context of DCVC


Biological context of DCVC


Anatomical context of DCVC


Associations of DCVC with other chemical compounds


Gene context of DCVC


  1. The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells. Stevens, J., Hayden, P., Taylor, G. J. Biol. Chem. (1986) [Pubmed]
  2. Mechanistic analysis of S-(1,2-dichlorovinyl)-L-cysteine-induced cataractogenesis in vitro. Walsh Clang, C.M., Aleo, M.D. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  3. Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice. Reddy, R.N., Latendresse, J.R., Mehendale, H.M. Toxicology (2006) [Pubmed]
  4. S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity in the New Zealand white rabbit: characterization of proteinuria and examination of the potential role of oxidative injury. Davis, J.W., Blakeman, D.P., Jolly, R.A., Packwood, W.H., Kolaja, G.J., Petry, T.W. Toxicologic pathology. (1995) [Pubmed]
  5. A role for c-myc in chemically induced renal-cell death. Zhan, Y., Cleveland, J.L., Stevens, J.L. Mol. Cell. Biol. (1997) [Pubmed]
  6. The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates. Stevens, J.L., Ayoubi, N., Robbins, J.D. J. Biol. Chem. (1988) [Pubmed]
  7. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury. van de Water, B., Zoeteweij, J.P., de Bont, H.J., Nagelkerke, J.F. Mol. Pharmacol. (1995) [Pubmed]
  8. Mechanism of transport for toxic cysteine conjugates in rat kidney cortex membrane vesicles. Schaeffer, V.H., Stevens, J.L. Mol. Pharmacol. (1987) [Pubmed]
  9. Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity. Lash, L.H., Anders, M.W. Mol. Pharmacol. (1987) [Pubmed]
  10. Modes of action of trichloroethylene for kidney tumorigenesis. Lash, L.H., Parker, J.C., Scott, C.S. Environ. Health Perspect. (2000) [Pubmed]
  11. N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism. Wolfgang, G.H., Gandolfi, A.J., Stevens, J.L., Brendel, K. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  12. Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells. Shaik, Z.P., Fifer, E.K., Nowak, G. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  13. Protein kinase C-alpha inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells. Liu, X., Godwin, M.L., Nowak, G. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  14. Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca2+ and their association with cytotoxicity to renal cells. Vamvakas, S., Bittner, D., Dekant, W., Anders, M.W. Biochem. Pharmacol. (1992) [Pubmed]
  15. Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. Lash, L.H., Hueni, S.E., Putt, D.A. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  16. Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene. Lock, E.A., Barth, J.L., Argraves, S.W., Schnellmann, R.G. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  17. Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. Lash, L.H., Elfarra, A.A., Anders, M.W. J. Biol. Chem. (1986) [Pubmed]
  18. The transport of S-cysteine conjugates in LLC-PK1 cells and its role in toxicity. Schaeffer, V.H., Stevens, J.L. Mol. Pharmacol. (1987) [Pubmed]
  19. Na-dependent transport of S-(1,2-dichlorovinyl)-L-cysteine by renal brush-border membrane vesicles. Wright, S.H., Wunz, T.M., North, J., Stevens, J.L. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  20. Effects of S-(1,2-dichlorovinyl)-L-cysteine on the transport of para-aminohippurate ion in renal plasma membrane vesicles. Chakrabarti, S., Vu, D.D., Côté, M.G. Toxicol. Lett. (1990) [Pubmed]
  21. Glutamine transaminase K is not a major cysteine S-conjugate beta-lyase of rat kidney mitochondria: evidence that a high-molecular weight enzyme fulfills this role. Abraham, D.G., Thomas, R.J., Cooper, A.J. Mol. Pharmacol. (1995) [Pubmed]
  22. Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. Xu, F., Putt, D.A., Matherly, L.H., Lash, L.H. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  23. Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide. Lash, L.H., Sausen, P.J., Duescher, R.J., Cooley, A.J., Elfarra, A.A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  24. Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition. van de Water, B., Zoeteweij, J.P., Nagelkerke, J.F. Arch. Biochem. Biophys. (1996) [Pubmed]
  25. Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains. Abraham, D.G., Cooper, A.J. Anal. Biochem. (1991) [Pubmed]
  26. Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes. Ripp, S.L., Itagaki, K., Philpot, R.M., Elfarra, A.A. Drug Metab. Dispos. (1999) [Pubmed]
  27. S-(1,2-dichlorovinyl)-L-cysteine-induced dedifferentiation and p53 gene mutations in LLC-PK1 cells: a comparative investigation with S-(2-chloroethyl)cysteine, potassium bromate, cis-platinum and styrene oxide. Richter, H., Vamvakas, S. Toxicol. Lett. (1998) [Pubmed]
  28. Inactivation of brain and kidney aspartate aminotransferases by S-(1,2,-dichlorovinyl)-L-cysteine and by S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine. Kato, Y., Asano, Y., Cooper, A.J. Dev. Neurosci. (1996) [Pubmed]
  29. Depletion of cytochrome P-450 and alterations in activities of drug metabolizing enzymes by S-(1,2-dichlorovinyl)-L-cysteine in mouse kidney cortex. Cojocel, C., Mayer, D. Arch. Toxicol. Suppl. (1989) [Pubmed]
WikiGenes - Universities