Disease relevance of Nantrodolum

• Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds [1].

High impact information on Nantrodolum

• Studies with [3H]nantradol hydrochloride indicate that nantradol is extensively metabolized after oral administration [2].
• When substituted in lieu of codeine under an intravenous drug self-administration procedure, neither levonantradol nor nantradol maintained responding at rates higher than those maintained by their vehicle [3].
• Single doses of THC, nantradol, and nabilone depressed the flexor and skin twitch reflexes and had a calming effect after intravenous infusion [4].

Analytical, diagnostic and therapeutic context of Nantrodolum

• The use of high-pressure liquid chromatography with electrochemical detection for the assay of nantradol and its application to delta 9- tetrahydrocannabinol [5].
• In support of pharmacological and clinical studies with nantradol, a potent, nonopioid analgetic, a specific HPLC/electrochemical assay for nantradol and related compounds in plasma was recently developed [5].

References