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Chemical Compound Review

Norflex     N,N-dimethyl-2-[(2- methylphenyl)-phenyl...

Synonyms: Plenactol, Euflex, Flexon, Flexor, Tega-Flex, ...
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Disease relevance of Euflex


Psychiatry related information on Euflex


High impact information on Euflex

  • This mechanism is optimized by unique musculoskeletal adaptations: the digital flexor muscles have extremely short fibres and significant passive properties, whereas the tendons are very long and span several joints [11].
  • Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF [12].
  • Current applied to the presynaptic lateral giant (LG) axon or to the neurite of the postsynaptic giant flexor motoneurone (MoG) spreads passively through the synapse into the adjacent neurone [13].
  • Rather, the unique structure of the forelimb is probably the result of evolved changes in the short head of biceps brachii to enhance its role as a forearm flexor [14].
  • In all limbs, a supernumerary preaxial digit is formed, but the flexor of the hindlimb toes is missing [15].

Chemical compound and disease context of Euflex

  • Baclofen regularly alleviated involuntary flexor or extensor spasms and increased resistance to passive movement of the legs but did not alter strength, gait, stretch reflexes, or clonus [16].
  • HbA1c Values Determine the Outcome of Intrasheath Injection of Triamcinolone for Diabetic Flexor Tenosynovitis [17].
  • Dantrolene is well established in the treatment of patients with muscle spasticity where it generally improves at least some of the components of spasticity (i.e. hyper/hypotonia, clonus, muscle cramps and spasms, resistance to stretch and flexor reflexes, articular movement, neurological and motor functions and urinary control) [18].
  • In the chronic spinal cat preparation, ED70 values for reduction of flexor spasms of 2.2 and 4.0 mg/kg by iv and po routes of administration, respectively, were observed for kojic amine, which was the most potent of the various hydroxypyrone derivatives investigated [19].
  • Before adding gamma-aminobutyric acid (GABA) or glycine receptor agonists and antagonists, rhythmic motor activity was induced by bath application of acetylcholine (ACh), N-methyl-D,L-aspartate (NMA), or serotonin (5-HT) while monitoring bilateral ankle flexor and extensor electroneurograms (ENGs) [20].

Biological context of Euflex

  • By 24 hours after onset, 93 poor-outcome patients were identified by motor responses that were absent, extensor, or flexor and by spontaneous eye movements that were neither orienting nor roving conjugate; only one regained independent function [21].
  • In this respect, it is our opinion that rhythms and neural components always interact, just like flexor and extensor tones or excitatory and inhibitory cardiovascular reflexes, and that it is misleading to separately consider vagal and sympathetic modulations of heart rate [22].
  • M-35, which displaced 125I-labeled galanin from membranes of rat dorsal spinal cord with an IC50 of 0.3 nM, dose-dependently antagonized the effect of intrathecal galanin on the flexor reflex [23].
  • Other abnormalities included long-latency responses in the extremities in 2 patients, release of H-reflexes from flexor hallucis brevis muscle in 2 patients, and an Hmax/Mmax ratio of 98% in 2 patients [24].
  • Stretch reflex dynamics in spastic elbow flexor muscles [25].

Anatomical context of Euflex

  • More than 30 years ago, Frank and Fuortes proposed that the synaptic effectiveness of muscle spindle afferents associated with spinal motoneurones could be diminished by the activation of nerves from flexor muscles [26].
  • Dbx1 mutant mice lacking these ventral interneurons exhibit an increased incidence of cobursting between left and right flexor/extensor motor neurons during drug-induced locomotion [27].
  • We demonstrate how commissural interneurons (CINs), whose axons traverse the midline to innervate contralateral neurons, are organized such that distinct flexor and extensor centers in the rostral lumbar spinal cord define activity in both flexor and extensor caudal motor pools [28].
  • There was median-nerve neuropathy due to infiltration of the flexor retinaculum with amyloid in six patients [29].
  • The structure of rigor crossbridges was examined by comparing rigor crossbridges in fast muscle fibers from glycerol-extracted abdominal flexor muscle of crayfish with those in "natively decorated" thin filaments from the same muscle [30].

Associations of Euflex with other chemical compounds


Gene context of Euflex

  • The decrease in binding results in the inability of galanin to inhibit the C fibers stimulation-induced facilitation of the rat flexor reflex, demonstrating that peptide-PNA constructs act in vivo to suppress expression of functional galanin receptors [36].
  • M40 acts as a weak antagonist of galanin in the spinal flexor reflex model [37].
  • Eya1 expression is largely restricted to flexor tendons, while Eya2 is expressed in the extensor tendons and ligaments of the phalangeal elements of the limb [38].
  • Anti-sense IRAP probes bound to two of nine RA tissues, two of six OA tissues, one of one seronegative inflammatory arthropathy tissue, and none of one flexor tenosynovitis tissue [39].
  • Furthermore, N/OFQ (1 nmol) administered blocked SP ( flexor responses, which were abolished by pertussis toxin pretreatment or in NOR gene knockout (NOR(-/-)) mice [40].

Analytical, diagnostic and therapeutic context of Euflex

  • To investigate this I have now developed an animal model where changes occur in the threshold and responsiveness of the flexor reflex following peripheral injury that are analogous to the sensory changes found in man [41].
  • Furthermore, we show that the digital flexor muscles have minimal ability to contribute to or regulate significantly the 2.5-Hz cycle of movement, but are ideally arranged to damp these high-frequency oscillations in the limb [11].
  • Elbow flexor muscle strength declined by -5.5% (95% CI = -9.6% to -1. 4%) per 4 weeks in the control group but remained stable (0.0%; 95% CI= -1.4% to +1.4%) in the ATP group (P =.01) [42].
  • Our recent experiments, using patch clamp techniques, indicate that no tight electrical coupling is present between satellite cells and the muscle fiber dissociated from rat flexor digitorum brevis [43].
  • Electromyography (EMG) signals arising from the wrist extensor and flexor muscles, and a high-resolution EEG were recorded simultaneously [44].


  1. Flexor reflex control of the external sphincter of the urethra in paraplegia. Jolesz, F.A., Cheng-Tao, X., Ruenzel, P.W., Henneman, E. Science (1982) [Pubmed]
  2. Suppurative flexor tenosynovitis after accidental self-inoculation with Streptococcus pneumoniae type I. Little, J.S., O'Reilly, M.J., Higbee, J.W., Camp, R.A. JAMA (1984) [Pubmed]
  3. Remitting seronegative symmetrical synovitis with pitting edema. RS3PE syndrome. McCarty, D.J., O'Duffy, J.D., Pearson, L., Hunter, J.B. JAMA (1985) [Pubmed]
  4. Functional recovery and orthopedic management of brachial plexus palsies. Hoffer, M.M., Braun, R., Hsu, J., Mitani, M., Temes, K. JAMA (1981) [Pubmed]
  5. Skeletal muscle response to exercise training in congestive heart failure. Minotti, J.R., Johnson, E.C., Hudson, T.L., Zuroske, G., Murata, G., Fukushima, E., Cagle, T.G., Chick, T.W., Massie, B.M., Icenogle, M.V. J. Clin. Invest. (1990) [Pubmed]
  6. Bone density in young women is associated with body weight and muscle strength but not dietary intakes. Henderson, N.K., Price, R.I., Cole, J.H., Gutteridge, D.H., Bhagat, C.I. J. Bone Miner. Res. (1995) [Pubmed]
  7. Is systemically administered oxytocin an analgesic in rats? Xu, X.J., Wiesenfeld-Hallin, Z. Pain (1994) [Pubmed]
  8. Effect of thumb anaesthesia on weight perception, muscle activity and the stretch reflex in man. Marsden, C.D., Rothwell, J.C., Traub, M.M. J. Physiol. (Lond.) (1979) [Pubmed]
  9. Evidence favouring presynaptic inhibition between antagonist muscle afferents in the human forearm. Berardelli, A., Day, B.L., Marsden, C.D., Rothwell, J.C. J. Physiol. (Lond.) (1987) [Pubmed]
  10. A familial tetraphocomelia syndrome involving limb deformities, cleft lip, cleft palate, and associated anomalies--a new syndrome. Kucheria, K., Bhargava, S.K., Bamezai, R., Bhutani, P. Hum. Genet. (1976) [Pubmed]
  11. Horses damp the spring in their step. Wilson, A.M., McGuigan, M.P., Su, A., van Den Bogert, A.J. Nature (2001) [Pubmed]
  12. The corticomotoneurone connection is normal in Parkinson's disease. Dick, J.P., Cowan, J.M., Day, B.L., Berardelli, A., Kachi, T., Rothwell, J.C., Marsden, C.D. Nature (1984) [Pubmed]
  13. Conductance and dye permeability of a rectifying electrical synapse. Margiotta, J.F., Walcott, B. Nature (1983) [Pubmed]
  14. Telemetered electromyography of forelimb muscle chains in gibbons (Hylobates lar). Jungers, W.L., Stern, J.T. Science (1980) [Pubmed]
  15. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Peters, H., Neubüser, A., Kratochwil, K., Balling, R. Genes Dev. (1998) [Pubmed]
  16. An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. A double-blind, cross-over study. Duncan, G.W., Shahani, B.T., Young, R.R. Neurology (1976) [Pubmed]
  17. HbA1c Values Determine the Outcome of Intrasheath Injection of Triamcinolone for Diabetic Flexor Tenosynovitis. Kameyama, M., Funae, O., Meguro, S., Atsumi, Y. Diabetes Care (2006) [Pubmed]
  18. Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. Ward, A., Chaffman, M.O., Sorkin, E.M. Drugs (1986) [Pubmed]
  19. Kojic amine--a novel gamma-aminobutyric acid analogue. Atkinson, J.G., Girard, Y., Rokach, J., Rooney, C.S., McFarlane, C.S., Rackham, A., Share, N.N. J. Med. Chem. (1979) [Pubmed]
  20. Effects of inhibitory amino acid antagonists on reciprocal inhibitory interactions during rhythmic motor activity in the in vitro neonatal rat spinal cord. Cowley, K.C., Schmidt, B.J. J. Neurophysiol. (1995) [Pubmed]
  21. Predicting outcome from hypoxic-ischemic coma. Levy, D.E., Caronna, J.J., Singer, B.H., Lapinski, R.H., Frydman, H., Plum, F. JAMA (1985) [Pubmed]
  22. Cardiovascular neural regulation explored in the frequency domain. Malliani, A., Pagani, M., Lombardi, F., Cerutti, S. Circulation (1991) [Pubmed]
  23. Galanin-mediated control of pain: enhanced role after nerve injury. Wiesenfeld-Hallin, Z., Xu, X.J., Langel, U., Bedecs, K., Hökfelt, T., Bartfai, T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  24. Periodic leg movements of sleep (nocturnal myoclonus): an electrophysiological study. Wechsler, L.R., Stakes, J.W., Shahani, B.T., Busis, N.A. Ann. Neurol. (1986) [Pubmed]
  25. Stretch reflex dynamics in spastic elbow flexor muscles. Powers, R.K., Campbell, D.L., Rymer, W.Z. Ann. Neurol. (1989) [Pubmed]
  26. Presynaptic inhibition of muscle spindle and tendon organ afferents in the mammalian spinal cord. Rudomin, P. Trends Neurosci. (1990) [Pubmed]
  27. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Lanuza, G.M., Gosgnach, S., Pierani, A., Jessell, T.M., Goulding, M. Neuron (2004) [Pubmed]
  28. Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. Butt, S.J., Kiehn, O. Neuron (2003) [Pubmed]
  29. Neuropathy, M components, and amyloid. Benson, M.D., Cohen, A.S., Brandt, K.D., Cathcart, E.S. Lancet (1975) [Pubmed]
  30. Rigor crossbridges are double-headed in fast muscle from crayfish. Bard, F., Franzini-Armstrong, C., Ip, W. J. Cell Biol. (1987) [Pubmed]
  31. Changes in architecture of the Golgi complex and other subcellular organelles during myogenesis. Ralston, E. J. Cell Biol. (1993) [Pubmed]
  32. Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise. Park, J.H., Brown, R.L., Park, C.R., Cohn, M., Chance, B. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  33. Neuropeptide proctolin in postural motoneurons of the crayfish. Bishop, C.A., Wine, J.J., O'Shea, M. J. Neurosci. (1984) [Pubmed]
  34. Presynaptic and long-lasting postsynaptic inhibition during penicillin-induced spinal seizures. Davenport, J., Schwindt, P.C., Crill, W.E. Neurology (1978) [Pubmed]
  35. Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. Costa, F., Sulur, P., Angel, M., Cavalcante, J., Haile, V., Christman, B., Biaggioni, I. Hypertension (1999) [Pubmed]
  36. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Pooga, M., Soomets, U., Hällbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J.X., Xu, X.J., Wiesenfeld-Hallin, Z., Hökfelt, T., Bartfai, T., Langel, U. Nat. Biotechnol. (1998) [Pubmed]
  37. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Bartfai, T., Langel, U., Bedecs, K., Andell, S., Land, T., Gregersen, S., Ahrén, B., Girotti, P., Consolo, S., Corwin, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  38. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Xu, P.X., Cheng, J., Epstein, J.A., Maas, R.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  39. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. Firestein, G.S., Berger, A.E., Tracey, D.E., Chosay, J.G., Chapman, D.L., Paine, M.M., Yu, C., Zvaifler, N.J. J. Immunol. (1992) [Pubmed]
  40. Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. Inoue, M., Shimohira, I., Yoshida, A., Zimmer, A., Takeshima, H., Sakurada, T., Ueda, H. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  41. Evidence for a central component of post-injury pain hypersensitivity. Woolf, C.J. Nature (1983) [Pubmed]
  42. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. Agteresch, H.J., Dagnelie, P.C., van der Gaast, A., Stijnen, T., Wilson, J.H. J. Natl. Cancer Inst. (2000) [Pubmed]
  43. Membrane currents of rat satellite cells attached to intact skeletal muscle fibers. Bader, C.R., Bertrand, D., Cooper, E., Mauro, A. Neuron (1988) [Pubmed]
  44. Tremor-correlated cortical activity in essential tremor. Hellwig, B., Häussler, S., Schelter, B., Lauk, M., Guschlbauer, B., Timmer, J., Lücking, C.H. Lancet (2001) [Pubmed]
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