Disease relevance of Dimethylallyl alcohol

• Besides the preferred substrate isopentenyl monophosphate, the recombinant peppermint and E. coli kinases also phosphorylate isopentenol, and, much less efficiently, dimethylallyl alcohol, but dimethylallyl monophosphate does not serve as a substrate [1].
• Biosynthesis of polysaccharides in Acetobacter xylinum. Sequential synthesis of a heptasaccharide diphosphate prenol [2].

High impact information on Dimethylallyl alcohol

• The identity of the prenol involved in N-linked glycosylation in the fission yeast Schizosaccharomyces pombe was unknown [3].
• Dolichol and prenol failed to induce apoptosis [4].

Biological context of Dimethylallyl alcohol

• Finally, since the synthesis of reduced amounts of Glc3Man9GlcNAc2-P-P-lipid was also a phenotype seen in another glycosylation mutant, Lec9, we analyzed the long-chain prenol in B211 cells [5].

Analytical, diagnostic and therapeutic context of Dimethylallyl alcohol

• Furthermore, product characterization by thin layer chromatography (TLC) confirmed that the major product was a long-chain prenol with a chain length of 95 carbons [6].
• Using this chromatography system, the resolution of separation (Rs) between octadecaprenol (prenol 18) and nonadecaprenol (prenol 19) was two times higher than that using conventional reversed-phase high-performance liquid chromatography [7].

References