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Chemical Compound Review:

LS-94087 2-[[3-hydroxy-2-methyl-6- [[3,5,12...

Synonyms: BRN 6038286, AC1L3DL5, 103450-92-6, Cyanomethyladriamycin, N-(Cyanomethyl)doxorubicin

Gao, Y.G. et al., Versluis, A.J. et al., Versluis, A.J. et al., Skovsgaard, T. et al.

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Disease relevance of Daunorubicin derivative

Rubidazone, a semisynthetic daunorubicin derivative, was administered to 33 patients with advanced solid tumors or malignant lymphomas [1].

High impact information on Daunorubicin derivative

Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct [2].
Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes [3].
Synthesis of a lipophilic daunorubicin derivative and its incorporation into lipidic carriers developed for LDL receptor-mediated tumor therapy [4].

References

Clinical trial of rubidazone in solid tumors and malignant lymphomas. Skovsgaard, T., Hansen, H.H., Mouridsen, H.T., Nissen, N.I., Pedersen-Bjergaard, J. Cancer treatment reports. (1978) [Pubmed]
Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct. Gao, Y.G., Liaw, Y.C., Li, Y.K., van der Marel, G.A., van Boom, J.H., Wang, A.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes. Versluis, A.J., Rensen, P.C., Rump, E.T., Van Berkel, T.J., Bijsterbosch, M.K. Br. J. Cancer (1998) [Pubmed]
Synthesis of a lipophilic daunorubicin derivative and its incorporation into lipidic carriers developed for LDL receptor-mediated tumor therapy. Versluis, A.J., Rump, E.T., Rensen, P.C., Van Berkel, T.J., Bijsterbosch, M.K. Pharm. Res. (1998) [Pubmed]

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