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Chemical Compound Review:

S-Methyl GSH (2S)-2-amino-4-[[(1S)-1...

Synonyms: AG-E-95070, CHEMBL1233129, AC1L3GTT, CTK4G2973, AR-1J3609, ...

Atkins, W.M. et al., Serafín, A. et al., Manabe, Y. et al., Dietze, E.C. et al., Shimizu, T. et al., et al.

Atkins, Dietze, Ibarra,

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High impact information on S-Methyl glutathione

Transport of bile salts by MRP4 was negligible in the absence of ATP or without S-methyl-glutathione [1].
However, in presence of steatosis, an increased lipid peroxidation that could be reduced with glutathione-ester pretreatment was observed after hepatic reperfusion [2].
The S-methyl GSH yields an "anomalous" spectrum at pH 7.5, which retains cross-peaks consistent with ionized tyrosinate [3].
Addition of S-methyl GSH converted the "soft" active site to a noncompressible site that exhibited negligible pressure-dependent ionization of Tyr 9 below 0.8 kbar [4].
That of S-methyl GSH, on the other hand, resulted in a significant reduction of DNA damage by radiation [5].

Analytical, diagnostic and therapeutic context of S-Methyl glutathione

The Hydra bioassay system utilizes a tentacle ball formation (TBF), a component of the feeding response of hydra, elicited by S-methyl-glutathione [6].

References

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Rius, M., Nies, A.T., Hummel-Eisenbeiss, J., Jedlitschky, G., Keppler, D. Hepatology (2003) [Pubmed]
Ischemic preconditioning increases the tolerance of Fatty liver to hepatic ischemia-reperfusion injury in the rat. Serafín, A., Roselló-Catafau, J., Prats, N., Xaus, C., Gelpí, E., Peralta, C. Am. J. Pathol. (2002) [Pubmed]
Ligand effects on the fluorescence properties of tyrosine-9 in alpha 1-1 glutathione S-transferase. Dietze, E.C., Wang, R.W., Lu, A.Y., Atkins, W.M. Biochemistry (1996) [Pubmed]
Pressure-dependent ionization of Tyr 9 in glutathione S-transferase A1-1: contribution of the C-terminal helix to a "soft" active site. Atkins, W.M., Dietze, E.C., Ibarra, C. Protein Sci. (1997) [Pubmed]
Protective role of glutathione synthesis on radiation-induced DNA damage in rabbit brain. Shimizu, T., Iwanaga, M., Yasunaga, A., Urata, Y., Goto, S., Shibata, S., Kondo, T. Cell. Mol. Neurobiol. (1998) [Pubmed]
Hydra biological detection of biologically active peptides in rat cerebrospinal fluid. Manabe, Y., Yamazaki, H., Fukuda, C., Inoue, K., Fushiki, T., Hanai, K. Brain Res. Brain Res. Protoc. (2000) [Pubmed]

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