Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Pirlimycin (2S,4R)-N-[(1S,2S)-2-chloro- 1-[(2R,3R,4S...

Synonyms: Pirsue, SureCN204862, CHEMBL2107176, AC1L3GYE, FT-0673947, ...

This record was replaced with 157385.

Qadri, S.M. et al., Evans, M.E. et al., Ahonkhai, V.I. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pirlimycin

In vitro comparison of clindamycin and pirlimycin (U-57930E) activity against Staphylococcus aureus [1].
Methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, penicillin-resistant Streptococcus pneumoniae, and enterococci were resistant to U-57930E [2].
In vitro activity of U-57930E, a new clindamycin analog, against aerobic gram-positive bacteria [2].
Clindamycin, on the other hand, gave MIC values of 0.5 microgram/ml for B. fragilis, P. prevotii and P. asaccharolyticus, 0.25 for Propionibacterium sp. All strains of Clostridium perfringens were inhibited by 0.5 microgram/ml of U-57930E [3].
Both clindamycin and U-57930E showed similar MIC values for all strains of Fusobacterium nucleatum and Propionibacterium acnes tested [3].

High impact information on Pirlimycin

The activities of clindamycin and its derivative, pirlimycin (U-57930E), were compared against 100 strains of Staphylococcus aureus, using a microtiter broth dilution technique [1].

References

In vitro comparison of clindamycin and pirlimycin (U-57930E) activity against Staphylococcus aureus. Evans, M.E., Patterson, L.S., Stratton, C.W. Antimicrob. Agents Chemother. (1982) [Pubmed]
In vitro activity of U-57930E, a new clindamycin analog, against aerobic gram-positive bacteria. Ahonkhai, V.I., Cherubin, C.E., Shulman, M.A., Jhagroo, M., Bancroft, U. Antimicrob. Agents Chemother. (1982) [Pubmed]
In vitro activity of U-57930E against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline. Qadri, S.M., Karim, M.R., Flournoy, D.J. J. Antibiot. (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share