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Disease relevance of Fusobacterium


High impact information on Fusobacterium

  • 6-Phospho-alpha-glucosidase (EC from B. subtilis cross-reacts with polyclonal antibody to maltose 6-phosphate hydrolase from Fusobacterium mortiferum, and the two proteins exhibit amino acid sequence identity of 73% [6].
  • Using an overlay technique, we previously showed that the Gram-negative periodontal pathogen Fusobacterium nucleatum binds to a glycoprotein of Mr 89,000 (Prakobphol, A., Murray, P., and Fischer, S.J. (1987) Anal. Biochem. 164, 5-11) in the parotid saliva of some individuals [7].
  • Purification and characterization of C-S lyase from Fusobacterium varium. A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids [8].
  • Of the 13 anaerobic oral bacterial species, F. nucleatum and Fusobacterium necrophorum were among the best inducers of collagenase 3 mRNA levels, a powerful matrix metalloproteinase [9].
  • In this study, we investigated the ability of Fusobacterium nucleatum subsp. nucleatum to increase its tissue-invasive potential by acquiring cell-associated human matrix metalloproteinase 9 (MMP-9) activity [10].

Chemical compound and disease context of Fusobacterium


Biological context of Fusobacterium


Anatomical context of Fusobacterium


Gene context of Fusobacterium

  • However, with Fusobacterium nucleatum stimulation, there was a significant decrease in CD23, CD21 and CD22 expression after 3 d in culture, which corresponds to the activation time for B-cells [26].
  • HBD-2 mRNA was induced by cell wall extract of Fusobacterium nucleatum, an oral commensal microorganism, but not by that of Porphyromonas gingivalis, a periodontal pathogen [27].
  • Gingival mononuclear cell production of interleukin 1 (IL-1), interleukin 6 (IL-6) and transforming growth factor-beta (TGF-beta) after stimulation with the putative periodontopathic bacteria, Porphyromonas gingivalis and Fusobacterium nucleatum was investigated [28].
  • Next, we cloned the gene that encodes S. oralis GAPDH and found that the sequence had a high degree of homology with the sequences of GAPDHs of various bacteria, including Streptococcus gordonii and Fusobacterium nucleatum [29].
  • Nitric oxide production and iNOS mRNA expression in mice induced by repeated stimulation with live Fusobacterium nucleatum [30].

Analytical, diagnostic and therapeutic context of Fusobacterium


  1. Antimicrobial drugs used in the management of anaerobic infections in children. Brook, I. Drugs (1983) [Pubmed]
  2. Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars. Kolenbrander, P.E., Andersen, R.N. Infect. Immun. (1989) [Pubmed]
  3. Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004). Ednie, L.M., Jacobs, M.R., Appelbaum, P.C. Antimicrob. Agents Chemother. (1997) [Pubmed]
  4. Activities of garenoxacin (BMS-284756) and other agents against anaerobic clinical isolates. Hecht, D.W., Osmolski, J.R. Antimicrob. Agents Chemother. (2003) [Pubmed]
  5. Actinobacillus actinomycetemcomitans serotype b lipopolysaccharide mediates coaggregation with Fusobacterium nucleatum. Rosen, G., Nisimov, I., Helcer, M., Sela, M.N. Infect. Immun. (2003) [Pubmed]
  6. The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily. Thompson, J., Pikis, A., Ruvinov, S.B., Henrissat, B., Yamamoto, H., Sekiguchi, J. J. Biol. Chem. (1998) [Pubmed]
  7. Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein. Gillece-Castro, B.L., Prakobphol, A., Burlingame, A.L., Leffler, H., Fisher, S.J. J. Biol. Chem. (1991) [Pubmed]
  8. Purification and characterization of C-S lyase from Fusobacterium varium. A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids. Tomisawa, H., Suzuki, S., Ichihara, S., Fukazawa, H., Tateishi, M. J. Biol. Chem. (1984) [Pubmed]
  9. Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells. Uitto, V.J., Baillie, D., Wu, Q., Gendron, R., Grenier, D., Putnins, E.E., Kanervo, A., Firth, J.D. Infect. Immun. (2005) [Pubmed]
  10. Binding of pro-matrix metalloproteinase 9 by Fusobacterium nucleatum subsp. nucleatum as a mechanism to promote the invasion of a reconstituted basement membrane. Gendron, R., Plamondon, P., Grenier, D. Infect. Immun. (2004) [Pubmed]
  11. Identification of a galactose-binding lectin on Fusobacterium nucleatum FN-2. Murray, P.A., Kern, D.G., Winkler, J.R. Infect. Immun. (1988) [Pubmed]
  12. Capillary agar diffusion assay for measuring metronidazole in human gingival crevice fluid. Notten, F., Koek-Van Oosten, A., Mikx, F. Antimicrob. Agents Chemother. (1982) [Pubmed]
  13. Fastidious anaerobe agar compared with Wilkins-Chalgren agar, brain heart infusion agar, and brucella agar for susceptibility testing of Fusobacterium species. Brazier, J.S., Goldstein, E.J., Citron, D.M., Ostovari, M.I. Antimicrob. Agents Chemother. (1990) [Pubmed]
  14. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Girard, A.E., Girard, D., English, A.R., Gootz, T.D., Cimochowski, C.R., Faiella, J.A., Haskell, S.L., Retsema, J.A. Antimicrob. Agents Chemother. (1987) [Pubmed]
  15. Characterization of endotoxin from Fusobacterium necrophorun. Garcia, M.M., Charlton, K.M., McKay, K.A. Infect. Immun. (1975) [Pubmed]
  16. Identification of a Fusobacterium nucleatum PK1594 galactose-binding adhesin which mediates coaggregation with periopathogenic bacteria and hemagglutination. Shaniztki, B., Hurwitz, D., Smorodinsky, N., Ganeshkumar, N., Weiss, E.I. Infect. Immun. (1997) [Pubmed]
  17. Methylation of adenine and cytosine in some strains of Fusobacterium nucleatum. Bolstad, A.I., Jensen, H.B. Microb. Pathog. (1993) [Pubmed]
  18. Phylogeny of Firmicutes with special reference to Mycoplasma (Mollicutes) as inferred from phosphoglycerate kinase amino acid sequence data. Wolf, M., Müller, T., Dandekar, T., Pollack, J.D. Int. J. Syst. Evol. Microbiol. (2004) [Pubmed]
  19. Activation of c-Jun N-terminal kinase in the absence of NFkappaB function prior to induction of NK cell death triggered by a combination of anti-class I and anti-CD16 antibodies. Jewett, A. Hum. Immunol. (2001) [Pubmed]
  20. Oligosaccharides obtained by partial hydrolysis of lipopolysaccharide from Fusobacterium nucleatum F1. Hofstad, T., Aadnegard, B. J. Periodont. Res. (1986) [Pubmed]
  21. Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria. Asai, Y., Ohyama, Y., Taiji, Y., Makimura, Y., Tamai, R., Hashimoto, M., Ogawa, T. J. Dent. Res. (2005) [Pubmed]
  22. Preterm labor and bacterial intraamniotic infection: arachidonic acid liberation by phospholipase A2 of Fusobacterium nucleatum. Mikamo, H., Kawazoe, K., Sato, Y., Imai, A., Tamaya, T. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  23. Interleukin-6 production by human monocytes treated with granulocyte-macrophage colony-stimulating factor in the presence of lipopolysaccharide of oral microorganisms. Baqui, A.A., Meiller, T.F., Chon, J.J., Turng, B.F., Falkler, W.A. Oral Microbiol. Immunol. (1998) [Pubmed]
  24. A non-lectin-like mechanism by which Fusobacterium nucleatum 10953 adheres to and activates human lymphocytes. Tuttle, R.S., Strubel, N.A., Mourad, J., Mangan, D.F. Oral Microbiol. Immunol. (1992) [Pubmed]
  25. Cytokine, elastase and oxygen radical release by Fusobacterium nucleatum-activated leukocytes: a possible pathogenic factor in periodontitis. Sheikhi, M., Gustafsson, A., Jarstrand, C. Journal of clinical periodontology. (2000) [Pubmed]
  26. Phenotypic analysis of B-cells extracted from human periodontal disease tissue. Gemmell, E., Seymour, G.J. Oral Microbiol. Immunol. (1991) [Pubmed]
  27. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Krisanaprakornkit, S., Kimball, J.R., Weinberg, A., Darveau, R.P., Bainbridge, B.W., Dale, B.A. Infect. Immun. (2000) [Pubmed]
  28. Interleukin 1, interleukin 6 and transforming growth factor-beta production by human gingival mononuclear cells following stimulation with Porphyromonas gingivalis and Fusobacterium nucleatum. Gemmell, E., Seymour, G.J. J. Periodont. Res. (1993) [Pubmed]
  29. Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis functions as a coadhesin for Porphyromonas gingivalis major fimbriae. Maeda, K., Nagata, H., Yamamoto, Y., Tanaka, M., Tanaka, J., Minamino, N., Shizukuishi, S. Infect. Immun. (2004) [Pubmed]
  30. Nitric oxide production and iNOS mRNA expression in mice induced by repeated stimulation with live Fusobacterium nucleatum. Kato, C., Mikami, M., Saito, K. Microbiol. Immunol. (2001) [Pubmed]
  31. Purification of arginine-sensitive hemagglutinin from Fusobacterium nucleatum and its role in coaggregation. Takemoto, T., Ozaki, M., Shirakawa, M., Hino, T., Okamoto, H. J. Periodont. Res. (1993) [Pubmed]
  32. Penicillin failure in the treatment of Bacteroides fragilis lung abscess. Experimental study in rabbits. Thadepalli, H., Kannangara, D.W., Bach, V.T. Chemotherapy. (1983) [Pubmed]
  33. Characterization of shared antigens of Fusobacterium nucleatum and Fusobacterium necrophorum. Kaur, M., Falkler, W.A. Oral Microbiol. Immunol. (1992) [Pubmed]
  34. Synergistic effect on blastogenesis in murine spleen cells of lipopolysaccharide, lipid A, and acid-degraded polysaccharide from Fusobacterium nucleatum. Sveen, K., Hofstad, T. FEMS microbiology immunology. (1991) [Pubmed]
  35. Differentiation between gram-negative anaerobic bacteria by pyrolysis gas chromatography of lipopolysaccharides. Dahlén, G., Ericsson, I. J. Gen. Microbiol. (1983) [Pubmed]
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