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Chemical Compound Review

Pirlimycin     (2S,4R)-N-[(1S,2S)-2-chloro- 1-[(2R,3R,4S...

Synonyms: Pirlimycina, Pirlimycine, Pirlimycinum, SureCN301657, CHEMBL1652611, ...
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Disease relevance of Pirlimycin


High impact information on Pirlimycin


Chemical compound and disease context of Pirlimycin


Biological context of Pirlimycin


Anatomical context of Pirlimycin

  • Cows infected with S. uberis in one or both experimentally challenged mammary glands were randomly allocated to three groups, representing three different treatment regimens with pirlimycin, including 2-day (n = 21 cows, 31 mammary quarters), 5-day (n = 21 cows, 32 quarters), and 8-day (n = 26 cows, 40 quarters) [10].

Associations of Pirlimycin with other chemical compounds


Analytical, diagnostic and therapeutic context of Pirlimycin

  • Pirlimycin is absorbed in rats and mice following both subcutaneous and oral administration [3].
  • A reversed-phase high-performance liquid chromatographic (HPLC) assay method has been developed for determining pirlimycin in human serum and urine [13].
  • Of the quarters infected at 14 d before expected parturition, 76% (19 of 25) were uninfected following treatment with penicillin-novobiocin; 59% (17 of 29) were uninfected following treatment with pirlimycin, and 26% (5 of 19) were uninfected in the untreated negative control group [14].
  • Determination and confirmation of pirlimycin residue in bovine milk and liver by liquid chromatography/thermospray mass spectrometry: interlaboratory study [15].
  • A cure was defined as an experimentally infected mammary gland that was treated with pirlimycin and was bacteriologically negative for the presence of S. uberis at 7, 14, 21, and 28 days after treatment [10].


  1. Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests. Thornsberry, C., Marler, J.K., Watts, J.L., Yancey, R.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  2. Activity of pirlimycin (U57930E) against strains of the Bacteroides fragilis group. Garcia-Rodriguez, J.A., Garcia-Sanchez, J.E., Prieto, J., Sanchez de S Lorenzo, A. Antimicrob. Agents Chemother. (1982) [Pubmed]
  3. Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent. Birkenmeyer, R.D., Kroll, S.J., Lewis, C., Stern, K.F., Zurenko, G.E. J. Med. Chem. (1984) [Pubmed]
  4. Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin. L??thje, P., Schwarz, S. J. Antimicrob. Chemother. (2007) [Pubmed]
  5. Effect of prepartum intramammary treatment with pirlimycin hydrochloride on prevalence of early first-lactation mastitis in dairy heifers. Middleton, J.R., Timms, L.L., Bader, G.R., Lakritz, J., Luby, C.D., Steevens, B.J. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  6. Factors affecting cure and somatic cell count after pirlimycin treatment of subclinical mastitis in lactating cows. Deluyker, H.A., Van Oye, S.N., Boucher, J.F. J. Dairy Sci. (2005) [Pubmed]
  7. In vitro susceptibility of Helicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A). Westblom, T.U., Midkiff, B.R., Czinn, S.J. Eur. J. Clin. Microbiol. Infect. Dis. (1993) [Pubmed]
  8. Short communication: Efficacy of parenteral ceftiofur for treatment of systemically mild clinical mastitis in dairy cattle. Wenz, J.R., Garry, F.B., Lombard, J.E., Elia, R., Prentice, D., Dinsmore, R.P. J. Dairy Sci. (2005) [Pubmed]
  9. Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach. Whittem, T. J. Vet. Pharmacol. Ther. (1999) [Pubmed]
  10. Efficacy of extended pirlimycin therapy for treatment of experimentally induced Streptococcus uberis intramammary infections in lactating dairy cattle. Oliver, S.P., Almeida, R.A., Gillespie, B.E., Ivey, S.J., Moorehead, H., Lunn, P., Dowlen, H.H., Johnson, D.L., Lamar, K.C. Vet. Ther. (2003) [Pubmed]
  11. Activity of selected antimicrobial agents against strains of Staphylococcus aureus isolated from bovine intramammary infections that produce beta-lactamase. Watts, J.L., Salmon, S.A. J. Dairy Sci. (1997) [Pubmed]
  12. The postantibiotic effect of selected antibiotics on Staphylococcus aureus Newbould 305 from bovine intramammary infection. Owens, W.E., Washburn, P.J., Ray, C.H. Zentralblatt Veterinarmedizin Reihe B (1993) [Pubmed]
  13. High-performance liquid chromatographic assay of pirlimycin in human serum and urine using 9-fluorenylmethylchloroformate. Shah, J.A., Weber, D.J. J. Chromatogr. (1984) [Pubmed]
  14. Influence of prepartum pirlimycin hydrochloride or penicillin-novobiocin therapy on mastitis in heifers during early lactation. Oliver, S.P., Gillespie, B.E., Ivey, S.J., Lewis, M.J., Johnson, D.L., Lamar, K.C., Moorehead, H., Dowlen, H.H., Chester, S.T., Hallberg, J.W. J. Dairy Sci. (2004) [Pubmed]
  15. Determination and confirmation of pirlimycin residue in bovine milk and liver by liquid chromatography/thermospray mass spectrometry: interlaboratory study. Heller, D.N. Journal of AOAC International. (1996) [Pubmed]
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