Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CH3NHOH N-methylhydroxylamine

Synonyms: CHEMBL144761, NCI-C60066, AG-G-11598, LS-77435, CTK1H0490, ...

Swarts, J.C. et al., Andersson, S. et al., Deguchi, T. et al.

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High impact information on N-methylhydroxylamine

Potassium cyanide, N-methylhydroxylamine, p-hydroxymercuribenzoate, and desferrioxamine were efficient inhibitors, whereas typical cytochrome P450 (P450) inhibitors were ineffective [1].
In the case of N-methylhydroxylamine the rate constant (0.41 M-1 s-1 at pH 7.6) decreases with pH, and it is concluded that the protonated form CH3NH2+OH(pKa = 6.2) has little or no reactivity with Tyr [2].
Kinetics analysis indicated that N-methylhydroxylamine competes with N-methyl-N'-nitro-N-nitrosoguanidine for guanylate cyclase [3].

References

Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime. Andersson, S., Hofmann, Y., Nordling, A., Li, X.Q., Nivelius, S., Andersson, T.B., Ingelman-Sundberg, M., Johansson, I. Drug Metab. Dispos. (2005) [Pubmed]
Kinetic studies on the reduction of the tyrosyl radical of the R2 subunit of E. coli ribonucleotide reductase. Swarts, J.C., Aquino, M.A., Han, J.Y., Lam, K.Y., Sykes, A.G. Biochim. Biophys. Acta (1995) [Pubmed]
Blockade by N-methylhydroxylamine of activation of guanylate cyclase and elevations of guanosine 3',5'-monophosphate levels in nervous tissues. Deguchi, T., Saito, M., Kono, M. Biochim. Biophys. Acta (1978) [Pubmed]

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